Updates in Non-Operating Room Anesthesia.

Purpose Of Review: With an increase in the number and complexity of procedures in nonoperating room anesthesia (NORA) locations, navigating the landscape of planning, scheduling, workflow, and patient and clinician safety adds to the challenges of NORA space, requiring coordination of multiple teams and regulatory platforms.

Recent Findings: With the constant increase in cases performed in the NORA space, expected to reach 50% of all anesthetics in the next decade, significant strides must be made in assuring patients' and clinicians' safety. New procedures have been developed and approved in all procedural areas, and anesthesiologists are leading the charge in getting all stakeholders together.

Mobile Stroke Units Address Socioeconomic Disparities in Care.

Background And Objectives: Strokes disproportionately affect underprivileged populations. Mobile stroke units (MSUs) bring diagnostic and treatment tools for stroke directly to patients. This study assessed how MSUs in Rochester, New York, address disparities in stroke care.

Classifying Continuous Glucose Monitoring Documents From Electronic Health Records.

Background: Clinical use of continuous glucose monitoring (CGM) is increasing storage of CGM-related documents in electronic health records (EHR); however, the standardization of CGM storage is lacking. We aimed to evaluate the sensitivity and specificity of CGM Ambulatory Glucose Profile (AGP) classification criteria.

Methods: We randomly chose 2244 (18.

"I Thought I Was Going to Die": Identifying Gaps in the Intimate Partner Violence Service Provision System for Black Women.

Black women experience the highest mortality and morbidity resulting from intimate partner violence (IPV) victimization, yet there remains a dearth of culturally responsive interventions designed to meet their needs within the coordinated community response system. We employed the Theory of Help-Seeking Behavior to explicate the barriers that Black women experience when securing assistance from providers within the IPV service provision system, inclusive of the criminal legal, child protective service, shelter, healthcare, and mental healthcare systems. In-depth individual interviews were conducted with 30 people who self-identified as Black women who were help-seeking within the IPV service provision system at the time of data collection.

Robust Assessments of Lithium Mining Impacts Embodied in Global Supply Chain Require Spatially Explicit Analyses.

Lithium is a critical material for the energy transition, but its mining causes significant environmental impacts that will intensify due to surging global demand. Here, we conduct a mining site-specific environmental impact assessment of lithium on a global scale, focusing on greenhouse gas (GHG) emissions, water use, and land use. We then track the production and international trade flows of all lithium-containing commodities to assess how lithium mining impacts are distributed across global supply chains.

Midterm Evaluation of EUS-guided Gastroenterostomy for Gastric Outlet Obstruction: An International Collaborative Study.

Background: EUS-guided gastroenterostomy (EUS-GE) is a minimally invasive therapy for the management of gastric outlet obstruction (GOO). EUS-GE has demonstrated excellent short-term efficacy without the risks of surgical bypass. However, there is limited data on follow-up outcomes.

"Rigorous and Systematic Qualitative Data Analysis in Biological Anthropology".

Biological anthropologists have long engaged in qualitative data analysis (QDA), though such work is not always foregrounded. In this article, we discuss the role of rigorous and systematic QDA in biological anthropology and consider how it can be understood and advanced. We first establish what kinds of qualitative data and analysis are used in biological anthropology.

Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis-a pilot study in adult patients.

Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2-h dwell using 2 L of dialysate containing 2.

Interferons and Cytokines Induce Transcriptional Activation of the Long-Interspersed Element-1 in Myeloid Cells from Autoimmune Patients.

Approximately 17% of our genome consists of copies of the retrotransposon "long interspersed element-1" (LINE-1 or L1). Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the L1-encoded ORF1 protein (ORF1p), which correlate with disease activity and interferon gene signature. ORF1p is present in neutrophils from patients with active disease in perinuclear ribonucleoprotein particles that also contain Ro60 and nucleic acid sensors.

Endocrine therapy and risk of cardiovascular disease and mortality in postmenopausal breast cancer survivors.

Background: There are increasing concerns of cardiovascular safety related to endocrine therapy use in women with breast cancer (BC). We examined risk of cardiovascular disease (CVD) events and mortality associated with endocrine therapy use in postmenopausal women with early-stage BC.

Methods: Postmenopausal women diagnosed with stage I-III hormone receptor-positive BC from 2005 to 2013 were included (n = 8,495).

Two New Kindreds with Complete Factor D Deficiency.

Inborn deficiencies of the alternative pathway (AP) of the complement system have been associated with life-threatening infections, mainly by encapsulated bacteria. Complete factor D (FD) deficiencies have been reported in only seven families in the literature. We report two new cases of biochemically and genetically confirmed complete FD deficiency, including the first in a Down syndrome patient.

Impact of commercial RNA extraction methods on the recovery of human RNA sequence data from archival fixed tissues.

Archival fixed tissues hold key insights into the evolutionary history of RNA viruses and the associated host immune response, yet access to the RNA sequence data is limited by a lack of robust methods for RNA extraction and sequence retrieval from these tissue types. Here we compared three commercial RNA extraction techniques (bead, column, and phase-based) on five fixed human brain tissues done in triplicate, that have been stored for up to 43 years. We found that for this sample set, bead-based extractions captured longer molecules and yielded a greater proportion of unique reads when aligned to the human genome, than did column and phase-based extraction methods.

Cross-Cultural Adaptation and Translation of the Neck Dissection Impairment Index (NDII) into Spanish.

ImportanceSelective, modified radical, and radical neck dissections are common surgical procedures that can result in significant musculoskeletal issues of the neck and shoulder. Quality-of-life evaluations after neck dissection must assess and quantify these dysfunctions to allow subsequent comparison of outcomes after different treatments.ObjectiveThere is no validated Spanish-language questionnaire designed to evaluate neck and shoulder dysfunction after cervical lymphadenectomy.

Factors related to parenting difficulties among caregivers of adolescents with attention-deficit/hyperactivity disorder during the COVID-19 pandemic.

Background: Caregivers of children with attention-deficit/hyperactivity disorder (ADHD) experience more parenting stress than do caregivers of children without ADHD. Evidence suggests that ADHD severity is positively associated with parenting stress. In adolescents, ADHD increases the risks of contracting Coronavirus disease 2019 (COVID-19) and having poor outcomes.

Heat treatment activates futile calcium cycling in brown adipose tissue to modulate energy metabolism and alters gut microbiota in C57BL/6 mice.

Aim: Aging decreases the metabolic rate and increases the risk of metabolic diseases, highlighting the need for alternative strategies to improve metabolic health. Heat treatment (HT) has shown various metabolic benefits, but its ability to counteract aging-associated metabolic slowdown remains unclear. This study aimed to investigate the impact of whole-body HT on energy metabolism, explore the potential mechanism involving the heat sensor TRPV1, and examine the modulation of gut microbiota.

A Randomized Controlled Trial of Percutaneous Tibial Nerve Stimulation in the Treatment of Female Sexual Dysfunction.

Background: Female sexual dysfunction (FSD) is a prevalent and multifaceted condition affecting women's sexual well-being. This randomized controlled trial aimed to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) compared to a validated sham control in the treatment of FSD.

Methods: We conducted a single-center randomized controlled trial.

Do child and household regulation moderate the bidirectional relation between harsh parenting and externalizing problems in the transition to adolescence?

The present study examined several distinct indicators of regulation (i.e., task-based executive function, surveyed child effortful control, and surveyed household chaos) as moderators of longitudinal bidirectional links between developmental changes in harsh parenting (HP) and child externalizing behaviors (EXT) from age 9 to 14 years.

Medicaid Home and Community Based Services Spending and Nursing Home Use by Individuals Under the Age of 44.

Prior studies of the role of state spending on home and community-based services (HCBS) in nursing home use focused on adults over the age of 65. However, medically complex children and adults under 50 years old represent a small (about 5%) but highly vulnerable subset of nursing home patients. We measured the impact of HCBS spending on short-term and long-term nursing home stays by children and adults under 44 years old and compared the impact between Non-Hispanic White (NHW) individuals and Black, Indigenous, and People of Color (BIPOC).

Novel device therapies in heart failure: focus on patient selection.

The increasing prevalence of heart failure (HF) has led to advancements in therapeutic strategies, including the development of new pharmacological treatments and the expansion of guideline recommendations across the spectrum of left ventricular ejection fractions. Despite these advancements, the full benefits of guideline-directed medical therapy (GDMT) are often limited by various barriers that result in incomplete implementation or suboptimal responses. For patients who cannot tolerate or only partially respond to GDMT, therapeutic options remain limited.

Ethical Considerations of Percutaneous Endoscopic Gastrostomy Tube Placement in a Patient With Creutzfeldt-Jakob Disease and Advanced Dementia.

Background: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive neurodegenerative condition that is not easily diagnosed and has no curative treatments available, essentially requiring palliative measures, including tube feeding. Nonetheless, data shows that the endoscope used for percutaneous endoscopic gastrostomy (PEG) tube insertion can be a vector for CJD transmission.

Case Presentation: We discuss the case of an elderly patient diagnosed with CJD, requiring tube feeding.

A New Paradigm in Hospital Medicine: Evaluating the Effects of Geographical Cohorting on Health Care Delivery.

Background: Geographical cohorting in hospital settings represents a significant shift from traditional patient rounding practices and aims to enhance the efficiency of health care delivery. This model assigns hospitalists to a particular inpatient unit, where most of their patients are located. While this model has several benefits, including streamlining health care procedures, optimizing resource allocation, and fostering better provider communication, its implementation is not without its challenges.

Updating a Rural Clinic in Tiburón, Haiti.

Background: Tiburón is a small fishing village in Haiti with a clinic overseen by the Oblate missionaries and the Ministry of Public Health and Population (MSPP). This village was hugely impacted by Hurricane Matthew in 2016, leading to increased health care demands. The clinic was inaccessible from the furthest parts of the village and lacked basic medication supplies and adequate manpower.

Consensus statement on the prevention, diagnosis, and management of infection following transcutaneous osseointegration for patients with limb loss: current state-of-the-art and proposed future studies.

The diagnosis, risk factors, treatment algorithms, and long-term sequelae of superficial and deep, implant-related infections in transdermal, bone-anchored osseointegration are not well-defined. In contrast to the robust experience diagnosing and managing periprosthetic joint infections in total joint arthroplasty, osseointegration surgery has only recently been adopted at a small number of osseointegration centers in the United States, contributing to the lack of long-term outcomes. Through the pooled experience from these osseointegration centers, we present a consensus statement on the perioperative management, incidence, treatment, and diagnostic workup for infectious complications following transdermal, bone-anchored osseointegration.