1 results match your criteria: "New Jersey Medical School of University of Medicine and Dentistry of New Jersey[Affiliation]"
Cell Calcium
May 2008
Department of Pharmacology and Physiology, New Jersey Medical School of University of Medicine and Dentistry of New Jersey, Medical Science Building, H609, 185 South Orange Avenue, P.O. Box 1709, Newark, NJ 07103-1709, USA.
In hepatocytes, hormones linked to the formation of the second messenger inositol 1,4,5-trisphosphate (InsP3) evoke transient increases or spikes in cytosolic free calcium ([Ca2+]i), that increase in frequency with the agonist concentration. These oscillatory Ca2+ signals are thought to transmit the information encoded in the extracellular stimulus to down-stream Ca2+-sensitive metabolic processes. We have utilized both confocal and wide field fluorescence microscopy techniques to study the InsP3-dependent signaling pathway at the cellular and subcellular levels in the intact perfused liver.
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