The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI.

The translation of AI-generated brain metastases (BM) segmentation into clinical practice relies heavily on diverse, high-quality annotated medical imaging datasets. The BraTS-METS 2023 challenge has gained momentum for testing and benchmarking algorithms using rigorously annotated internationally compiled real-world datasets. This study presents the results of the segmentation challenge and characterizes the challenging cases that impacted the performance of the winning algorithms.

Child neglect and maternal cross-relational social cognitive and neurocognitive disturbances.

A social information processing (SIP) theory of parenting risk posits that social-cognitive and neurocognitive incapacities characterize at-risk parents, and that these cognitive difficulties operate across relational domains. This study focused on highly disadvantaged mothers of preschoolers and compared mothers with histories of perpetrating child neglect (n = 69) to demographically similar mothers without such histories (n = 76). Participants completed measures of unrealistic expectations for children and other adults, social problem-solving in parenting and nonparenting situations, executive functioning (EF), and attributions for children and other adults.

Near-Field Characterization of Methane Emission Variability from a Compressor Station Using a Model Aircraft.

A model aircraft equipped with a custom laser-based, open-path methane sensor was deployed around a natural gas compressor station to quantify the methane leak rate and its variability at a compressor station in the Barnett Shale. The open-path, laser-based sensor provides fast (10 Hz) and precise (0.1 ppmv) measurements of methane in a compact package while the remote control aircraft provides nimble and safe operation around a local source.

Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).

The pregnane X receptor (PXR) is an orphan nuclear receptor predominantly expressed in liver and intestine. PXR coordinates hepatic responses to prevent liver injury induced by environmental toxins. PXR activates cytochrome P450 3A4 gene expression upon binding to rifampicin (Rif) and clotrimazole (CTZ) by recruiting transcriptional coactivators.