The feasibility of sharing digital audio-recordings of clinic visits online with older adults in primary care settings: A multisite trial.

Objective: The objective of this trial was to determine the feasibility, acceptability, and preliminary effectiveness of sharing audio recordings of primary care visits with older adults with multimorbidity.

Methods: We used a two-arm, randomized, controlled, feasibility trial with 3-month follow-up. Patients aged ≥ 65 years-with diabetes and hypertension-were recruited from academic primary care settings in New Hampshire, Tennessee, and Texas.

Comparison of Race-neutral Versus Race-specific Spirometry Equations for Evaluation of Child Asthma.

Rationale: Race-based estimates of pulmonary function in children could influence the evaluation of asthma in children from racial and ethnic minoritized backgrounds.

Objectives: To determine if race-neutral (GLI-Global) versus race-specific (GLI-Race-Specific) reference equations differentially impact spirometry evaluation of childhood asthma.

Methods: The analysis included 8,719 children aged 5 to <12 years from 27 cohorts across the United States grouped by parent-reported race and ethnicity.

A health economic analysis of noninjectable epinephrine compared with intramuscular epinephrine.

Background: Noninjectable epinephrine to treat allergic reactions addresses an unmet need. Intranasal epinephrine is approved and a sublingual form is under development. Inhaled epinephrine is poorly studied for anaphylaxis.

Temporal trends in online searches related to COVID-19 vaccine safety: A digital infodemiology study.

Background: The rapid development of COVID-19 vaccines may have raised public concerns about their safety and side effects in the United States (US). This study aimed to assess trends in online searches related to the safety and side effects of COVID-19 vaccines in the US from 2021-2022.

Methods: Google COVID-19 Vaccination Search Insights was used to analyze searches about COVID-19 vaccine safety and side effects in the US from January 4, 2021, to November 21, 2022 (98 weeks).

To err is human … so how can we prevent all ABO-incompatible transfusions?

Savin et al. report a retrospective analysis of ABO-incompatible red cell transfusions in the United Kingdom, France and Germany. In spite of varied strategies for bedside preventative measures, all three countries continue to identify preventable errors leading to ABO-incompatible red cell transfusions.

"They are not victimless crimes…that's frustrating to hear": Qualitative insights from prosecutors working on cases related to technology facilitated child sexual abuse material.

Background: Child sexual abuse material (CSAM) are any videos or images of individuals under the age of 18 engaging in sexually explicit activities or positions. The incidence and scope of CSAM has increased since the COVID-19 pandemic; however, the prosecution of such crimes has not risen at the same rate.

Objective: This study presents exploratory qualitative findings regarding prosecutors' challenges prosecuting CSAM cases from the perspectives of experienced CSAM prosecutors.

Microbiota Associated With Species (Nemertea, Hoplonemertea, Monostilifera, Ototyphlonemertidae) Reveal Evidence of Phylosymbiosis.

Phylosymbiosis, the association between the phylogenetic relatedness of hosts and the composition of their microbial communities, is a widespread phenomenon in diverse animal taxa. However, the generality of the existence of such a pattern has been questioned in many animals across the tree of life, including small-sized aquatic invertebrates. This study aims to investigate the microbial communities associated with poorly known marine interstitial nemerteans to uncover their microbiota diversity and assess the occurrence of phylosymbiosis.

Mechanically anisotropic phantoms for magnetic resonance elastography.

Purpose: Imaging phantoms with known anisotropic mechanical properties are needed to evaluate magnetic resonance elastography (MRE) methods to estimate anisotropic parameters. The aims of this study were to fabricate mechanically anisotropic MRE phantoms, characterize their mechanical behavior by direct testing, then assess the accuracy of MRE estimates of anisotropic properties using a transversely isotropic nonlinear inversion (TI-NLI) algorithm.

Methods: Directionally scaled and unscaled lattices were designed to exhibit anisotropic or isotropic mechanical properties.

Approach to the patient with hidradenitis suppurativa: Evaluating severity to guide therapy.

Hidradenitis suppurativa (HS) is a chronic condition with a multifaceted pathoetiology requiring a multimodal management approach. The HS evaluation process involves the use of multiple tools to determine the extent and activity of disease, patient-reported outcomes, and the effectiveness of therapy. The multimodal approach to treatment based on severity includes lifestyle modifications, topical medications, systemic antibiotics, immunomodulators, and surgical interventions.

Hawaiian High School Football Player Positional Differences in Helmet Impact Characteristics.

Context: The importance of analyzing head impact exposure among football players is well established, yet few studies have explored the differences across position groups in high school athletes. Better understanding of these differences may provide optimized intervention strategies for coaches and healthcare providers.

Objective: To quantify the difference of head impacts per exposure (Imp/E) and impact burden high school football player position groups.

Comparing the contents of patient-reported outcome measures for fatigue: EORTC CAT Core, EORTC QLQ-C30, EORTC QLQ-FA12, FACIT, PRO-CTCAE, PROMIS, Brief Fatigue Inventory, Multidimensional Fatigue Inventory, and Piper Fatigue Scale.

Background: To assess fatigue in cancer patients, several patient-reported outcome measures (PROMs) are available that differ in content. To support the selection of suitable measures for specific applications and to evaluate possibilities of quantitative linking, the present study provides a content comparison of common fatigue measures, scales, and item banks. We included the EORTC CAT Core, EORTC QLQ-FA12, EORTC QLQ-C30, FACIT-F, PROMIS Fatigue (Cancer item bank v1.

Assessing the efficacy and safety of STOP (successful treatment for paranoia)-an app-based cognitive bias modification therapy for paranoia: a randomised clinical trial protocol.

Background: Paranoia, the belief that you are at risk of significant physical or emotional harm from others, is a common difficulty, which causes significant distress and impairment to daily functioning, including in psychosis-spectrum disorders. According to cognitive models of psychosis, paranoia may be partly maintained by cognitive processes, including interpretation biases. Cognitive bias modification for paranoia (CBM-pa) is an intervention targeting the bias towards interpreting ambiguous social scenarios in a way that is personally threatening.

Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population.

The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to (i) evaluate the associations between body mass index (BMI), waist circumference (WC), and ∼5,000 plasma proteins (SomaScan v4), (ii) identify protein signatures of BMI and WC, and (iii) evaluate the associations between the protein signatures and cardiometabolic health including metabolically unhealthy obesity and type 2 diabetes incidence in the Singapore Multi-Ethnic Cohort (MEC1). Among 410 BMI-associated and 385 WC-associated proteins, we identified protein signatures of BMI and WC and validated them in an independent dataset across two timepoints and externally in the Atherosclerosis Risk in Communities (ARIC) study.

Museum-Based Education in Health Professions Learning: A 5-Year Retrospective.

A growing evidence base suggests that the integration of museum-based activities into health professions education can contribute to learner resilience and wellbeing, promote capacity for patient-centered care, and encourage equity in learning environments. However, the styles and methods for implementing museum-based programs vary widely across different institutions. This retrospective leverages the lessons learned from 5 years of experience implementing museum-based programs at one large academic institution to examine the various operational and logistical considerations in implementing a museum-based program for health professions learners.