Shared Local Oncology Care After Allogeneic Hematopoietic Cell Transplantation: A Randomized Clinical Trial.

Importance: Although sharing care with local oncologists after allogeneic hematopoietic cell transplantation (HCT) has been proposed for patients living far from HCT centers, it is not known whether a shared strategy is safe or improves patient quality of life (QOL).

Objective: To determine the efficacy and safety of sharing follow-up care after HCT between the HCT specialty center and local oncologists.

Design, Setting, And Participants: This was a multicenter collaborative randomized clinical trial of patients undergoing HCT at Dana-Farber Cancer Institute (DFCI)-a high volume HCT center in Boston (Massachusetts)-and 8 local oncology practices.

Conservation benefits of a large marine protected area network that spans multiple ecosystems.

Marine protected areas (MPAs) are widely implemented tools for long-term ocean conservation and resource management. Assessments of MPA performance have largely focused on specific ecosystems individually and have rarely evaluated performance across multiple ecosystems either in an individual MPA or across an MPA network. We evaluated the conservation performance of 59 MPAs in California's large MPA network, which encompasses 4 primary ecosystems (surf zone, kelp forest, shallow reef, deep reef) and 4 bioregions, and identified MPA attributes that best explain performance.

Public Health.

Background: This study aimed to assess associations between socioeconomic condition and cognitive function among Puerto Rican adults residing in the greater Boston Area.

Methods: We assessed the relationship between a score of social condition, encompassing education, income-to-poverty ratio, perceived stress, food security, and psychological acculturation, and cognitive function in a cohort of Puerto Rican Adults residing in the greater Boston area. The score was assessed over more than 12 years of follow-up and ranged from 0 (best social condition) to 15 (poorest social condition).

Developing Topics.

Background: The treatment of Alzheimer's Disease (AD) remains a challenge for modern medicine due to its complex pathogenesis. Traditional Chinese Medicine (TCM) has accumulated significant value and success in prevention and treatment of diseases, and are regarded as new and promising candidates of AD pharmacological treatments. The current study aimed to systematically evaluate the current evidence base for TCM as a treatment for AD.

Dementia Care Research and Psychosocial Factors.

Background: Resource-constrained rural areas face significant challenges in providing access to healthcare resources, especially for older adults, including those living with Alzheimer's disease and related dementia (ADRD). We seek to address these gaps by equipping six rural community sites in New Hampshire and Maine with tele-rehabilitative equipment. Libraries and community centers that serves youth and older adults, vital in rural communities, are identified as key partners to advance digital health literacy, equity, and telemedicine services for older adults including those living with ADRD, with the University of [blind for review] Center for Digital Health Innovation (CDHI).

Dementia Care Research and Psychosocial Factors.

Background: There is a growing number of residents living with dementia (RLWD) in long-term care (LTC) settings, but dementia care access and quality are more limited in communities with fewer health resources and these limitations are exacerbated by current dementia care workforce shortages. Low-resource LTC settings, including poorer urban and rural settings, serve older adults who are at high risk for health inequities in dementia care. These settings can experience barriers in providing quality dementia care due to their limited ability to capture pertinent information about residents' needs and preferences and ensuring that information is known by dementia care staff.

Dementia Care Practice.

Background: Low-resource residential long-term care (LTC) settings, including settings located in medically underserved and health professional shortage communities, have fewer environmental resources to support high-quality, robust data collection and use of measures to support person-centered dementia care (PCC). Further, such settings are more likely to serve older adults from populations that have experienced historic harms related to misuse of personal data, including low-income and minoritized populations. Design thinking engages community-members to understand a problem from the end-user's perspective (empathize and define), brainstorm new solutions (ideate), and develop proposed solutions (prototype and test).

Costs of Overly Broad Recalls.

Overly broad recalls following an FDA advisory occur when the source of an outbreak is originally misidentified or cannot be promptly identified. In this situation, an entire product category might be recalled (e.g.

Demographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure?

Prevalence of autism diagnosis has historically differed by demographic factors. Using data from 8224 participants drawn from the Environmental influences on Child Health Outcomes (ECHO) Program, we examined relationships between demographic factors and parent-reported autism-related traits as captured by the Social Responsiveness Scale (SRS; T score > 65) and compared these to relations with parent-reported clinician diagnosis of ASD, in generalized linear mixed effects regression analyses. Results suggested lower odds of autism diagnosis, but not of SRS T > 65, for non-Hispanic Black children (adjusted odds ratio [OR] = 0.

Aging Selectively Alters PRR and ISG Expression in Endo- and Ecto-Cervical Stromal Fibroblasts From the Human Female Reproductive Tract.

Problem: Aging alters immune function in women and can lead increased risk of infections, particularly in the female reproductive tract (FRT).

Method Of Study: To determine how aging affects innate immune responses in the cervical stroma of the FRT, we isolated endocervical (CX) and ectocervical (ECX) stromal fibroblasts and determine if their expression of multiple pattern recognition receptors (PRRs) and responses to viral stimulation varied with menopause and age.

Results: Constitutive expression of most PRRs did not vary with age or menopausal status in either cell type.

Mental Health Care Utilization and Prescription Rates Among Children, Adolescents, and Young Adults in France.

Importance: Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical.

Objective: To examine mental health care utilization and prescription rates for children, adolescents, and young adults before and after the COVID-19 pandemic.

Design, Setting, And Participants: This population-based time trend study used an interrupted time series analysis to examine mental health care and prescription patterns among the French population 25 years and younger.

Finding the Value: Identifying the Key Elements of Recorded Clinic Visits From the Perspective of Patients, Clinicians, and Caregivers.

Objective: We aimed to understand what patients, caregivers and clinicians identified as the most important information from their audio-recorded clinic visits and why.

Methods: We recruited patients, caregivers and clinicians from primary and speciality care clinics at an academic medical centre in New Hampshire, U.S.

Survival machine learning methods for mortality prediction after heart transplantation in the contemporary era.

Although prediction models for heart transplantation outcomes have been developed previously, a comprehensive benchmarking of survival machine learning methods for mortality prognosis in the most contemporary era of heart transplants following the 2018 donor heart allocation policy change is warranted. This study assessed seven statistical and machine learning algorithms-Lasso, Ridge, Elastic Net, Cox Gradient Boost, Extreme Gradient Boost Linear, Extreme Gradient Boost Tree, and Random Survival Forests in a post-policy cohort of 7,160 adult heart-only transplant recipients in the Scientific Registry of Transplant Recipients (SRTR) database who received their first transplant on or after October 18, 2018. A cross-validation framework was designed in mlr.

An optimized eDNA protocol for fish tracking in estuarine environments.

Environmental DNA (eDNA) is revolutionizing how we investigate biodiversity in aquatic and terrestrial environments. It is increasingly used for detecting rare and invasive species, assessing biodiversity loss and monitoring fish communities, as it is considered a cost-effective and noninvasive approach. Some environments, however, can be challenging for eDNA analyses.

Cooling perspectives on the risk of pathogenic viruses from thawing permafrost.

Climate change is inducing wide-scale permafrost thaw in the Arctic and subarctic, triggering concerns that long-dormant pathogens could reemerge from the thawing ground and initiate epidemics or pandemics. Viruses, as opposed to bacterial pathogens, garner particular interest because outbreaks cannot be controlled with antibiotics, though the effects can be mitigated by vaccines and newer antiviral drugs. To evaluate the potential hazards posed by viral pathogens emerging from thawing permafrost, we review information from a diverse range of disciplines.

Colon Cancer Rates Among Asian Americans: A 2017-2021 Epidemiological Analysis.

Colon cancer (CC) is a significant public health concern. With Asian Americans (AAs) representing a rapidly growing demographic in the United States, our study examined CC prevalence among AAs. The study merged the 2017-2021 Medical Expenditure Panel Survey and County Health Ranking.

Unraveling Caco-2 Cells through Functional and Transcriptomic Assessments.

The static Caco-2 monolayer is an extensively utilized model for predicting the permeability of small molecules during the drug development process. While these cells can differentiate and develop key functional and morphological features that emulate human enterocytes, they do not fully replicate the complexity of human intestinal physiology. In this study, we investigated functional and morphological aspects of Caco-2 cells, alongside their transcriptomic profiles, with a particular emphasis on genes encoding drug-metabolizing enzymes and drug transporters.

Terminology in ecology and evolutionary biology disproportionately harms marginalized groups.

The discipline of ecology and evolutionary biology (EEB) has long grappled with issues of inclusivity and representation, particularly for individuals with systematically excluded and marginalized backgrounds or identities. For example, significant representation disparities still persist that disproportionately affect women and gender minorities; Black, Indigenous, and People of Color (BIPOC); individuals with disabilities; and people who are LGBTQIA+. Recent calls for action have urged the EEB community to directly address issues of representation, inclusion, justice, and equity.

Platform capitalisms and platform cultures.

This article argues for a pluralization of the "platform capitalism" framework, suggesting we should think instead in terms of "platform capitalisms." This pluralization opens the way to a better account of how platforms work in different geocultural contexts, with our focus being on China, India and Japan. The article first outlines several roles the state has taken on in mediating platform capitalisms.

Heat and Drought Events Alter Biogenic Capacity to Balance CO Budget in South-Western Europe.

Heat and drought events are increasing in frequency and intensity, posing significant risks to natural and agricultural ecosystems with uncertain effects on the net ecosystem CO exchange (NEE). The current Vegetation Photosynthesis and Respiration Model (VPRM) was adjusted to include soil moisture impacts on the gross ecosystem exchange (GEE) and respiration ( ) fluxes to assess the temporal variability of NEE over south-western Europe for 2001-2022. Warming temperatures lengthen growing seasons, causing an increase in GEE, which is mostly compensated by a similar increment in .

Comparison of neuraminidase inhibiting antibody responses elicited by egg- and cell-derived influenza vaccines.

Unlabelled: Neuraminidase (NA)-specific antibodies contribute to immunity against influenza. While studies have demonstrated increased NA inhibiting (NAI) antibody titers after vaccination with egg-derived inactivated influenza vaccines (eIIV), the response to cell culture-derived (c) IIV has not been reported.

Methods: An immunogenicity sub-study was performed within a clinical trial comparing the effectiveness of egg, cell, and recombinant hemagglutinin (HA)-derived influenza vaccines during the 2018-2019 and 2019-2020 influenza seasons.