4,817 results match your criteria: "Neutrophilia"

Molecular Characteristics of Sweet Syndrome: A Systematic Review.

Exp Dermatol

December 2024

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Sweet syndrome (SS), originally described as acute febrile neutrophilic dermatosis, is a rare inflammatory skin condition, considered the prototype of neutrophilic dermatoses. It is characterised by the sudden onset of well-defined tender papules, plaques and nodules often accompanied by fever, neutrophilia and elevated markers of inflammation. Several variants have been described both clinically and histopathologically.

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Decitabine-induced Sweet syndrome.

BMJ Case Rep

December 2024

Pharmacy Practice, JSS College of Pharmacy, Mysuru, Karnataka, India

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin condition associated with the sudden onset of high-grade fever, painful rashes usually on the upper body, leukocytosis and neutrophilia. Approximately 21% of patients with Sweet syndrome have a concurrent malignancy, 80% of which are linked to haematological diseases, especially myelodysplastic syndrome and acute myeloid leukaemia. This is a case report of a woman in her 50s who was recently diagnosed with acute myeloid leukaemia and was started on decitabine 20 mg/m (40 mg).

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Acute Haemorrhagic Oedema of Infancy (AHOI), also known as Acute Hemorrhagic Edema of Infancy (AHEI), is characterized by purpuric skin lesions, edema, and fever. It is classified as a form of cutaneous leukocytoclastic vasculitis. Clinically, AHOI presents with targetoid, purplish spots on the face and limbs, accompanied by the sudden onset of peripheral edema.

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Background: Delayed cerebral injury (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is a preventable injury that would improve patient outcomes if an effective treatment can be developed. The most common long-term disability in patients with SAH is cognitive dysfunction. Contrary to the common theory that damage from DCI originates solely from ischemia caused by cerebral vasospasm, inflammation has been shown to be an important independent mediator of DCI.

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The spectrum of Ph-negative disease: CNL and CSF3R-related disorders.

Hematology Am Soc Hematol Educ Program

December 2024

Department of Pathology, Massachusetts General Hospital, Boston, MA.

Chronic neutrophilic leukemia (CNL) is a very rare myeloid neoplasm characterized by peripheral blood neutrophilia and a hypercellular marrow with increased granulopoiesis. An activating mutation in CSF3R is present in 80% to 90% of cases. CNL displays some biological overlap in terms of clinical presentation and behavior, as well as genetic profile, with several other myeloid neoplasms, particularly myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and other MPN.

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A 68-year-old woman with obesity and ulcerative colitis history, referred to the emergency department and transferred to the ICU, with severe epigastric belt-like abdominal pain (requiring opiates) with sudden onset 10 hours after the last meal. The clinical exploration presented painful abdomen with epigastrium peritoneal irritation. Laboratory tests showed elevated amylase (2600 U/l) and lipase (1127 U/l), with leukocytosis and neutrophilia.

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Acute generalised exanthematous pustulosis (AGEP) is a rare drug-induced pustular eruption characterised by the rapid onset of superficial pinhead pustules. We discuss the case of a 27-year-old man who presented with a generalised pustular eruption on the neck, trunk and limbs. He commenced upadacitinib for the treatment of atopic dermatitis (AD) 6 months before developing the rash, and the dose was increased from 15 to 30 mg daily, 3 months prior.

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Article Synopsis
  • Sickle cell emergencies are a leading reason for hospitalizations in patients with sickle cell disease, causing significant financial strain and increased health risks.
  • A study tracked 112 adults with sickle cell emergencies over four months, revealing a 38.41% readmission rate within 30 days, predominantly due to vaso-occlusive crises and acute chest syndrome.
  • Key factors predicting readmission included having a job, low levels of fetal hemoglobin, and certain blood cell counts (neutrophilia, lymphocytosis, thrombocytosis).
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Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study.

Viruses

October 2024

Research Group on Infections Difficult to Diagnose and Treat, Miguel Servet University Hospital, Institute for Health Research Aragón, 50009 Zaragoza, Spain.

In the frame of the I-MOVE-COVID-19 project, a cohort of 2050 patients admitted in two Spanish reference hospitals between March 2020 and December 2021 was selected and a range of clinical factor data were collected at admission to assess their impact on the risk COVID-19 severity outcomes through a multivariate adjusted analysis and nomograms. The need for ventilation and intensive care unit (ICU) admission were found to be directly associated with a higher death risk (OR 6.9 and 3.

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Association of Oral Tobacco-Free Nicotine Delivery Product with Acute Renal Tubular Necrosis.

Medicina (Kaunas)

November 2024

Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.

Article Synopsis
  • The use of non-tobacco oral nicotine delivery products (ONDPs) is rising among U.S. adolescents, but their toxic effects, particularly on kidneys, are not well-researched.
  • A case study of a 19-year-old male kidney transplant patient revealed that after using ZYN pouches, he experienced severe acute tubular injury without rejection or other infectious causes.
  • Follow-up indicated that while his kidney function worsened initially, it improved over time, highlighting the need for more comprehensive studies on the renal impacts of ONDPs.
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Article Synopsis
  • - The case details a 76-year-old man with severe COVID-19 and ground-glass pneumonia affecting 40-45% of his lungs, leading to complications during his hospitalization.
  • - Diagnostic tests revealed the presence of bacteria linked to Legionnaire's disease and ventilator-associated pneumonia, highlighting the complexity of treating patients with COVID-19.
  • - The study emphasizes the importance of recognizing rare pneumonias and their potential co-infections in COVID-19 cases to help improve early diagnosis and potentially reduce mortality rates.
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Background And Purpose: The immune response following aneurysmal subarachnoid hemorrhage (aSAH) can exacerbate secondary brain injury and impact clinical outcomes. As the immune response after aSAH is a dynamic process, we aim to track and characterize immune cell trajectories over time to identify patterns associated with various clinical outcomes.

Methods: In this retrospective single-center study of patients with aSAH, we analyzed immune cell count trajectories, including neutrophil, monocyte, and lymphocyte counts, collected from day 1 to day 14.

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CD56CD38 as a novel neutrophil-specific marker in chronic myeloid leukemia.

Heliyon

November 2024

Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China.

Background: Chronic myeloid leukemia (CML) is classified as a subtype of myeloproliferative neoplasm, and bone marrow flow cytometry does not reveal any specific immunophenotype. Interestingly, aberrant expression of cluster of differentiation (CD) markers such as CD56 and CD38 has been observed on neutrophils in CML patients. Therefore, we investigated the abnormal expression of CD56 and CD38 in CML neutrophils to explore their diagnostic value in identifying CML through flow cytometry.

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Vasculitis is an autoimmune disease defined by inflammation within blood vessels, typically manifesting systemically with multi-organ complications and clinical features. Isolated vasculitis itself, however, is extremely rare and not characteristically based on the pathophysiology of the condition. Whilst there have been cases of isolated vasculitis in large-medium vessels (e.

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Dietary Eicosapentaenoic Acid Improves Ozone-Induced Pulmonary Inflammation in C57BL/6 Mice.

J Nutr

November 2024

Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH, United States. Electronic address:

Background: Ambient concentrations of the air pollutant, ozone, are rising with increasing global temperatures. Ozone is known to increase incidence and exacerbation of chronic lung diseases, which will increase as ambient ozone levels rise. Studies have identified diet as a variable that is able to modulate the pulmonary health effects associated with ozone exposure.

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Background: Inhalation of biomass smoke is associated with adverse respiratory effects in those with chronic pulmonary conditions. There are few published data regarding the effects of anti-inflammatory interventions on these outcomes.

Objective: Our aim was to assess the effects of postexposure prednisone on woodsmoke (WS)-induced sputum neutrophilia.

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Article Synopsis
  • Acute respiratory distress syndrome (ARDS) is a severe condition that leads to high rates of ICU admissions and significant mortality, largely due to inflammation and oxidative stress, with few treatment options available.
  • Research using transgenic mice with a specific mutation in the antioxidant enzyme extracellular superoxide dismutase (EC-SOD) suggests that this mutation helps protect against pneumonia and lung injury by reducing inflammation and neutrophil recruitment.
  • The study shows that mice with the R213G variant of EC-SOD experience lower platelet activation and neutrophil influx during pneumonia, and treatment with an SOD mimetic further protects against these inflammatory responses.
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Appendiceal mucocele is a rare entity first described by Carl von Rokitansky, characterized by cystic dilatation of the appendiceal lumen due to obstruction, epithelial proliferation or inflammation and accumulation of mucoid material. The cause can be either neoplastic or non-neoplastic. Patients with appendiceal mucocele can be asymptomatic or present with right lower quadrant pain which may mimic acute appendicitis.

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Article Synopsis
  • Cholangiocarcinomas are malignant tumors originating from bile duct epithelium and are commonly found in dogs, particularly exotic breeds aged 2-5 years.
  • The study analyzed five cases reported from 2012 to 2021, focusing on clinical signs, blood tests, and postmortem examinations to improve diagnosis techniques.
  • Findings consistently included severe malnutrition, jaundice, anemia, and characteristic neoplastic cell clusters, although early diagnosis is challenging due to a lack of specific early-stage symptoms.
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Emergence of highly virulent and multidrug-resistant in breeding sheep with pneumonia, Hainan Province, China.

Front Microbiol

October 2024

Lab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, China.

Article Synopsis
  • The article discusses a pneumonia outbreak in sheep in Hainan Island, which led to acute deaths during winter 2021-2022, highlighting the challenges of raising sheep in the region's tropical climate.
  • Researchers conducted dissections and tests on six sheep, isolating a specific bacterial species responsible for the pneumonia, identified as multi-drug resistant with several virulence factors.
  • The study concluded that the virulent bacteria were capable of causing serious health issues in both sheep and a mouse infection model, indicating potential zoonotic risks due to similarities with strains affecting humans and other animals.
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Article Synopsis
  • A 41-year-old male with a history of cardiopathy and respiratory issues presented with severe symptoms related to heart failure, including significant dyspnea and edema after years of recurrent infections.
  • Diagnostic tests revealed multiple complications including dilation of cardiac chambers and a rare congenital condition known as H-type tracheoesophageal fistula (TEF), which contributed to his respiratory problems.
  • The patient was admitted to the ICU for intensive management, including treatment for pulmonary artery hypertension and preparation for surgical intervention to repair the fistula.
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Background: The overlapping clinical and radiographic features of pulmonary melioidosis and lung cancer present diagnostic challenges to healthcare providers in endemic settings.

Methods: We compared the clinical, laboratory and imaging characteristics of 19 pulmonary melioidosis cases with those of 15 cases of small cell lung cancer (SCLC) and 17 cases of non-small cell lung cancer (NSCLC).

Results: Compared with SCLC/NSCLC cases, those with pulmonary melioidosis were more likely to have diabetes, have fever, neutrophilia and leukocytosis on presentation (p<0.

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