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The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?
BMC Pulm Med
December 2016
Neurosurgery Department of First Hospital Affiliated to Soochow University, No. 188 Shizi Street, Gusu District, Su Zhou, Jiangsu Province, People's Republic of China.
Background: Saline fluid nebulization is highly recommend to combat the complications following tracheostomy, yet the understandings on the role of osmolality in saline solution for nebulization remain unclear.
Objectives: To investigate the biological changes in the early stage after tracheostomy, to verify the efficacy of saline fluid nebulization and explore the potential role of osmolality of saline nebulization after tracheostomy.
Methods: Sprague-Dawley rats undergone tracheostomy were taken for study model, the sputum viscosity was detected by rotational viscometer, the expressions of TNF-α, AQP4 in bronchoalveolar lavage fluid were assessed by western blot analysis, and the histological changes in endothelium were evaluated by HE staining and scanning electron microscopy (SEM).