Dopamine DL receptor density influences the recruitment of β-arrestin2 and G1 induced by antiparkinsonian drugs.

Introduction: Brain imaging studies have highlighted that the density of dopamine D receptors markedly fluctuates across the stages of Parkinson's disease and in response to pharmacological treatment. Moreover, receptor density constitutes a molecular determinant for the signaling profile of D receptor ligands. We therefore hypothesized that variations in receptor expression could influence D receptor response to antiparkinsonian drugs, most notably with respect to the recruitment bias between G and β-arrestin2.