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Exercises and Brain Stimulation to Preserve Function in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.

Neurol Clin Pract

February 2025

Sorbonne Université, Inserm, CNRS, Laboratoire d'Imagerie Biomédicale, LIB, F-75006, (MB, AP, P-FP, AL-V, VM-P), Paris; and APHP, Neurology Department in Pitié-Salpêtrière Hospital and ALS Referent Center, F-75013, (P-FP), Paris, France.

Background And Objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to the loss of motor function and muscle strength. Nonpharmacologic neuromodulative therapeutic approaches such as active exercise may contribute to preserve motor functions in ALS, but this hypothesis remains debated. The present meta-analysis first aimed to evaluate the effect of active exercise on function and muscle strength preservation.

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