376 results match your criteria: "Neurologic Effects of Caffeine"

[Successful resuscitation after energy drink consumption in a patient with unknown right ventricular dysplasia].

Anaesthesiologie

December 2024

Klinik für Intensivmedizin, Gemeinschaftsklinikum Mittelrhein gGmbH, Evangelisches Stift St. Martin, Akademisches Lehrkrankenhaus der Johannes Gutenberg-Universität Mainz, Johannes Müller-Straße 7, 56068, Koblenz, Deutschland.

Article Synopsis
  • - A 28-year-old man, naive to caffeine, collapsed after consuming 3 cans of an energy drink (480 mg of caffeine) post-football training, leading to successful CPR for ventricular fibrillation.
  • - After resuscitation, the patient was placed in the ICU where tests revealed he had an undiagnosed condition called right ventricular dysplasia and he received a single chamber implantable cardioverter defibrillator (ICD).
  • - He recovered without neurological issues and was discharged 14 days later, highlighting the potential risks of energy drinks in individuals with undiagnosed heart conditions, regardless of their physical fitness.
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Practical supplements for prevention and management of migraine attacks: a narrative review.

Front Nutr

October 2024

Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Migraine is one of the most debilitating neurological disorders that causes frequent attacks of headaches and affects approximately 11% of the global population. Deficient or even insufficient levels of vital nutrients would increase the severity and frequency of migraine attacks. Therefore, we aimed to examine the practical supplements for the prevention and management of migraine attacks.

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The impact of caffeine and glucose supplementation in a hypoxic environment on endurance exercise performance remains inconclusive. The current study examined the effect of pre-exercise carbohydrate and caffeine supplementation on endurance exercise performance in an acute hypoxic environment. Eight healthy active young males participated in this double-blind, within-subjects crossover study.

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Parkinson's disease is a neurodegenerative condition characterized by slow movement (bradykinesia), tremors, and muscle stiffness. These symptoms occur due to the degeneration of dopamine- producing neurons in the substantia nigra region of the brain, leading to reduced dopamine levels. The development of Parkinson's Disease (PD) involves a combination of genetic and environmental factors.

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Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.

Stroke

November 2024

Department of Pediatrics (J.K.M., Y.W., J.H., A.I., C.H., R.S.H., C.V., H.M., J.L.-B., J.R.F., D.M.F., E.M.), University of California San Francisco.

Article Synopsis
  • Neonatal hypoxic-ischemic encephalopathy primarily impacts low- and middle-income countries, with therapeutic hypothermia often proving ineffective, highlighting a need for earlier treatment strategies.
  • A study involved administering perinatal caffeine to near-term lambs undergoing severe hypoxia-ischemia, assessing its pharmacokinetics, safety, and efficacy in improving outcomes.
  • Caffeine administration enhanced neurodevelopmental results and decreased inflammation and gray matter damage, suggesting it could be a viable treatment for affected neonates compared to previous studies on other medications.
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The consumption of alcohol and caffeine affects the lives of billions of individuals worldwide. Although recent evidence indicates that caffeine impairs the reinforcing properties of alcohol, a characterization of its effects on alcohol-stimulated mesolimbic dopamine (DA) function was lacking. Acting as the pro-drug of salsolinol, alcohol excites DA neurons in the posterior ventral tegmental area (pVTA) and increases DA release in the nucleus accumbens shell (AcbSh).

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Caffeine: The Story beyond Oxygen-Induced Lung and Brain Injury in Neonatal Animal Models-A Narrative Review.

Antioxidants (Basel)

September 2024

Department of Neonatology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Article Synopsis
  • * Its antioxidant properties have been shown to have protective effects on brain and lung development in preterm infants, supported by various experimental studies.
  • * However, caffeine can also have negative effects when used outside of models involving oxidative stress, and its use should be carefully evaluated, especially beyond the recommended gestational age.
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The role of CART peptide in learning and memory: A potential therapeutic target in memory-related disorders.

Peptides

November 2024

Cellular and Molecular Research Center, Deputy of Research and Technology, Iran University of Medical Sciences, Tehran, Iran; Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Cocaine and amphetamine-regulated transcript (CART) mRNA and peptide are vastly expressed in both cortical and subcortical brain areas and are involved in critical cognitive functions. CART peptide (CARTp), described in reward-related brain structures, regulates drug-induced learning and memory, and its role appears specific to psychostimulants. However, many other drugs of abuse, such as alcohol, opiates, nicotine, and caffeine, have been shown to alter the expression levels of CART mRNA and peptides in brain structures directly or indirectly associated with learning and memory processes.

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Recent advances in pharmaceutical cocrystals of theophylline.

Nat Prod Bioprospect

September 2024

Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, 100050, People's Republic of China.

Article Synopsis
  • * Cocrystallization is highlighted as a promising technique to improve the physicochemical properties of theophylline, potentially reducing its toxicity and enhancing its effectiveness.
  • * The review discusses successful studies on cocrystals of theophylline, noting their ability to improve solubility, bioavailability, and interaction with other active pharmaceutical ingredients through hydrogen bonding.
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Coffee and Alzheimer's disease.

Prog Brain Res

August 2024

MedExplora Scientific Research Society, Yerevan, Armenia; Faculty of General Medicine, Yerevan State Medical University after Mikhtar Heratsi, Yerevan, Armenia.

Coffee, a universally consumed beverage, is known to contain thousands of bioactive constituents that have garnered interest due to their potential neuroprotective effects against various neurodegenerative disorders, including Alzheimer's disease (AD). Extensive research has been conducted on coffee constituents such as Caffeine, Trigonelline, Chlorogenic acid, and Caffeic acid, focusing on their neuroprotective properties. These compounds have potential to impact key mechanisms in AD development, including amyloidopathy, tauopathy, and neuroinflammation.

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From bean to brain: Coffee, gray matter, and neuroprotection in neurological disorders spectrum.

Prog Brain Res

August 2024

Department of Computing and Mathematics, Manchester Metropolitan University, Manchester, England, United Kingdom. Electronic address:

Coffee is a popular drink enjoyed around the world, and scientists are very interested in studying how it affects the human brain. This chapter looks at lots of different studies to understand how drinking coffee might change the brain and help protect it from neurodegenerative disorders especially like schizophrenia. With the help of available literature a link between the coffee mechanism and neurodegenerative disorders is established in this chapter.

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Coffee and mental disorders: How caffeine affects anxiety and depression.

Prog Brain Res

August 2024

Applied Physiology Research Center, Qom Medical Sciences, Islamic Azad University, Qom, Iran; Department of Basic Medical Sciences, Faculty of Medicine, Qom Medical Sciences, Islamic Azad University, Qom, Iran.

Caffeine, the main psychoactive component in coffee, has garnered significant attention for its potential impact on the most prevalent mental health conditions like anxiety and depression. This chapter comprehensively examines the neurobiological effects of caffeine, its influence on anxiety and depression, and relevant clinical studies. Caffeine exerts its psychostimulant effects primarily through antagonizing adenosine receptors, modulating neurotransmitter systems, and influencing intracellular calcium signaling in the brain.

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Traumatic brain injuries (TBIs) constitute a significant public health issue and a major source of disability and death in the United States and worldwide. TBIs are strongly associated with high morbidity and mortality rates, resulting in a host of negative health outcomes and long-term complications and placing a heavy financial burden on healthcare systems. One promising avenue for the prevention and treatment of brain injuries is the design of TBI-specific supplementation and dietary protocols centred around nutraceuticals and biochemical compounds whose mechanisms of action have been shown to interfere with, and potentially alleviate, some of the neurophysiological processes triggered by TBI.

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Caffeine, a nonselective adenosine receptor antagonist, is the major component of coffee and the most consumed psychostimulant at nontoxic doses in the world. It has been identified that caffeine consumption reduces the risk of several neurological diseases. However, the mechanisms by which it impacts the pathophysiology of neurological diseases remain to be elucidated.

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Objective: Sudden unexpected death in epilepsy (SUDEP) results in more years of potential life lost than any neurological condition with the exception of stroke. It is generally agreed that SUDEP happens due to some form of respiratory, cardiac, and electrocerebral dysfunction following a seizure; however, the mechanistic cause of these perturbations is unclear. One possible explanation lies with adenosinergic signaling.

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Update: Protective and risk factors for Parkinson disease.

Parkinsonism Relat Disord

August 2024

Dept. of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA; GRECC & Neurology Service, VAAAHS, Ann Arbor, MI, 48105, USA; University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, 48109, USA; University of Michigan Parkinson's Foundation Research Center of Excellence, USA. Electronic address:

Article Synopsis
  • The review explores various protective and risk factors associated with Parkinson's Disease (PD), identifying factors such as tobacco use, physical activity, and certain medications as potential protectors and issues like brain injury and pesticide exposure as risks.
  • Some protective factors may be influenced by reverse causation, meaning it’s unclear if they genuinely prevent PD or are related due to the disease itself.
  • Despite identifying these factors, the research has not yet produced effective prevention strategies or interventions for PD, suggesting that addressing broader public health concerns like Type 2 Diabetes and air pollution could be key to reducing PD incidence.
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Objective: This study was undertaken to investigate the effects of dietary caffeine intake on striatal dopamine function and clinical symptoms in Parkinson disease in a cross-sectional and longitudinal setting.

Methods: One hundred sixty-three early Parkinson disease patients and 40 healthy controls were investigated with [I]FP-CIT single photon emission computed tomography, and striatal dopamine transporter binding was evaluated in association with the level of daily coffee consumption and clinical measures. After a median interval of 6.

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Article Synopsis
  • * Caffeine's influence on seizures and the effectiveness of the antiepileptic drug topiramate (TPM) was studied using zebrafish larvae in a controlled experiment.
  • * Results showed that caffeine, especially at higher doses, reduced locomotor activity and TPM levels in zebrafish, indicating a complex interaction that could have implications for epilepsy treatment.
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Alzheimer's disease is a detrimental neurological disorder caused by the formation of amyloid fibrils due to the aggregation of amyloid-β peptide. The primary therapeutic approaches for treating Alzheimer's disease are targeted to prevent this amyloid fibril formation using potential inhibitor molecules. The discovery of such inhibitor molecules poses a formidable challenge to the design of anti-amyloid drugs.

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Neonatal respiratory distress syndrome (NRDS) is one of the major causes of pre-term mortality and morbidity among very-low-birth-weight infants (VLBWI) in low- and middle-income countries (LMIC). Some of the neonates pass away despite admission and care in intensive care units (ICUs). The present clinical trial seeks the application value of elevating oxygen saturation in the brain cells of pre-term neonates born with NRDS.

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Slow-wave sleep and REM sleep without atonia predict motor progression in Parkinson's disease.

Sleep Med

March 2024

Department of Neurology, Second Hospital Affiliated of Xinjiang Medical University, Ürümqi, 830063, Xinjiang, China; Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China. Electronic address:

Background: Growing evidence supports the potential role of sleep in the motor progression of Parkinson's disease (PD). Slow-wave sleep (SWS) and rapid eye movement (REM) sleep without atonia (RWA) are important sleep parameters. The association between SWS and RWA with PD motor progression and their predictive value have not yet been elucidated.

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Objectives: Caffeine's potential benefits on multiple sclerosis (MS), as well as on the ambulatory performance of non-MS populations, prompted us to evaluate its potential effects on balance, mobility, and health-related quality of life (HR-QoL) of persons with MS (PwMS).

Methods: This single-arm pilot clinical trial consisted of a 2-week placebo run-in and a 12-week caffeine treatment (200 mg/day) stage. The changes in outcome measures during the study period (weeks 0, 2, 4, 8, and 12) were evaluated using the Generalized Estimation Equation (GEE).

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Chronic tinnitus is a common neurological disorder that affects millions of patients globally with no available successful pharmacotherapy. It can be extremely bothersome to some patients to the extent that it occasionally qualifies as a disability that can hinder them from leading a normal life. In this short communication, the author discusses how he suffered from idiopathic tinnitus and how he managed to adopt a combined pathophysiological and pharmacological approach to the reason for the first time in the medical literature that low-dose metformin might be safely and effectively repurposed to manage at least a subset of tinnitus patients while discussing the potential role of adenosine receptor agonists as potential future tinnitus therapeutics.

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Caffeine - Essentials for anaesthesiologists: A narrative review.

J Anaesthesiol Clin Pharmacol

January 2023

Department of Anaesthesia, Pain Medicine and Critical Care, New Delhi, India.

Caffeine has a multitude of uses in anaesthesia, and numerous studies have evaluated its efficacy and usefulness in various aspects of anaesthesia and medical practice. Its various applications in anaesthesia include its role in awakening from anaesthesia, managing post-dural puncture headache, managing post-sedation paradoxical hyper-activity in children, post-operative bowel paralysis, and apnoea in paediatric populations, that is, apnoea in infancy, paediatric obstructive apnoea, and post-anaesthetic apnoea in pre-mature infants. Though the effects of caffeine on bronchial smooth muscle, neurological, and cardio-vascular systems are well known, the relatively little-known effects on the endocrine and gastro-intestinal (GI) system have been recently taking primacy for eliciting its therapeutic benefits.

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Article Synopsis
  • * Methodology: Researchers used advanced imaging techniques on 45 healthy adults, excluding those with neurological disorders or certain substance habits, to measure changes in brain metabolites before and after caffeine intake, alongside subjective sleepiness assessments.
  • * Findings indicate significant variations: The study found notable changes in key metabolites, especially among those who consumed more caffeine, with reductions in certain metabolites like GABA and increases in others such as GPC, demonstrating how caffeine can influence brain
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