1,576 results match your criteria: "Neurologic Complications of Organ Transplantation"
Stem cell transplantation therapy for advanced liver damage-associated neurodegenerative disorders.
Int J Surg
November 2024
Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Hepatic encephalopathy and other neurodegenerative disorders have profound implications for extensive liver impairment, calling for new ways of treating the condition. The application of stem cell transplantation to treat these severe disorders is a new and encouraging technique. This review article digs deep into the subject of stem cell transplantation therapy, neurodegenerative disorders associated with advanced liver damage, and liver transplantation.
View Article and Find Full Text PDFDiagnosis, treatment, management and monitoring of patients with tyrosinaemia type 1: Consensus group recommendations from the German-speaking countries.
J Inherit Metab Dis
January 2025
Department of Medical Psychology, Hannover Medical School, Hannover, Germany.
Hepatorenal tyrosinaemia (HT1) is an autosomal recessive disorder of tyrosine degradation resulting in hepatic and renal dysfunction, neurological sequelae may occur in some patients. The use of nitisinone (NTBC) has revolutionised treatment and outcome of this disorder. NTBC has to be combined with a low protein diet.
View Article and Find Full Text PDFReversibility of structural and functional alterations of hepatic encephalopathy.
Metab Brain Dis
December 2024
Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany.
Hepatic Encephalopathy (HE) is a frequent complication of chronic liver disease. Type C HE mainly appears in episodes; only seldom chronic persistent forms occur. HE can lead to hospitalization and it has a huge impact on the health related quality of life.
View Article and Find Full Text PDFMulti-proteomics and interactome dataset of tick-borne encephalitis virus infected host cells.
Sci Data
November 2024
Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, The First Hospital of Jilin University, Changchun, 130012, China.
Article Synopsis
Postoperative Pneumonia Risk in Children With Neurologic and Neuromuscular Disorders.
Hosp Pediatr
December 2024
Complex Care, Division of General Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Article Synopsis
- - The study analyzed over 63,000 surgical cases in children with complex chronic conditions to determine the prevalence and factors contributing to postoperative pneumonia (PoP) within 7 days of surgery, identifying significant variations across hospitals and surgical types.
- - The overall prevalence of PoP was found to be 1.1%, with the highest rates occurring in bone marrow and solid organ transplants, while procedures like craniofacial surgeries had much lower rates.
- - Children with four or more chronic conditions were at a notably higher risk for developing PoP, prompting the need for further research to reduce this risk, particularly for those with multiple health issues.
Outcome Through the Years of Left-Ventricular Assist Devices Therapy for End-Stage Heart Failure: A Review.
J Clin Med
November 2024
Cardiovascular Department, S. Bortolo Hospital, 36100 Vicenza, Italy.
Article Synopsis
- Heart transplantation is the top surgical option for severe heart failure, but limited organ donors and strict eligibility criteria have increased the use of long-term mechanical support like left ventricular assist devices (LVADs).
- Patients with LVADs often face multiple health issues and long-term complications, such as bleeding and infections, making them a vulnerable group.
- Advances in more biocompatible LVAD technology have reduced complications, and this review highlights the key complications and management strategies for patients using these devices.
The Impact of Early Indication of Living Donor Liver Transplantation on the Outcomes of Patients With Propionic Acidemia: A Single-Center Experience.
Pediatr Transplant
December 2024
Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
Article Synopsis
- Liver transplantation (LDLT) can effectively treat children with propionic acidemia (PA), showing a 100% survival rate in a study of 12 patients.
- The study compared outcomes based on the timing of LDLT, dividing patients into groups based on whether the surgery occurred within a year of their first metabolic decompensation or later.
- Early LDLT may prevent complications like cardiomyopathy and neurological issues, despite later patients showing some pre-existing conditions and post-surgery developmental challenges.
Variable Clinical Spectrum of Inborn Errors of Bile Acid Synthesis: A Report of 10 Cases.
Exp Clin Transplant
October 2024
From Gazi University School of Medicine, Department of Pediatric Gastroenterology Hepatology and Nutrition, Ankara, Turkey.
Article Synopsis
- - Inborn errors of bile acid synthesis are rare genetic disorders that can lead to liver disease and cholestasis, with symptoms varying from mild to severe, and diagnosed through genetic tests or urine analysis.
- - The study involved evaluating data from 10 patients diagnosed between 2013 and 2023, revealing different types of deficiencies, with the most common being 3β-hydroxy-Δ5-C27-steroid dehydrogenase deficiency.
- - Treatment approaches included cholic acid for most patients, with some requiring liver transplants or having severe outcomes, highlighting the potential for liver disease and complications from nutrient absorption issues.
Acute compartment syndrome of the leg following peroneus longus tendon graft harvesting: a case report.
J ISAKOS
December 2024
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Rua Dr. Ovídio Pires de Campos, 333 - Cerqueira Cesar, São Paulo, SP, CEP 05403-010, Brazil. Electronic address:
Article Synopsis
- - Acute compartment syndrome can occur as a rare complication after harvesting the peroneus longus tendon for ACL reconstruction surgery.
- - In a reported case, a patient experienced severe pain and nerve deficits just one day post-surgery, leading to an emergency fasciotomy to relieve pressure.
- - Fortunately, the patient fully recovered from the symptoms and neurological issues within 24 days, highlighting the importance of monitoring for this complication during the early postoperative period.
Nine Years of Continuous Flow LVAD (HeartMate 3): Survival and LVAD-Related Complications before and after Hospital Discharge.
J Cardiovasc Dev Dis
September 2024
Department of Thoracic and Cardiovascular Surgery, Tübingen University Hospital, 72076 Tübingen, Germany.
Background: End-stage heart failure is associated with high mortality. Recent developments such as the left ventricular assist device (LVAD) have improved patient outcomes. The HeartMate 3 LVAD is a novel centrifugal pump that was developed to provide hemodynamic support in heart failure patients, either as a bridge-to-transplant (BTT), myocardial recovery, or destination therapy (DT).
View Article and Find Full Text PDFMycophenolate Mofetil-Related Celiac-Like Enteropathy With Devastating Superior Mesenteric Artery Thrombosis and Gobbi Syndrome in a Renal Transplant Recipient.
Exp Clin Transplant
September 2024
>From the Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Article Synopsis
- Mycophenolate mofetil is commonly used as an immunosuppressant in transplant patients to prevent rejection but can cause gastrointestinal issues.
- A case was reported where a patient developed serious conditions resembling Gobbi syndrome, including celiac-like enteropathy, epilepsy, and brain calcifications after long-term use of the drug.
- This emphasizes the importance of careful monitoring for gastrointestinal and neurological symptoms in patients taking mycophenolate mofetil and indicates a need for more research to understand its effects and create management guidelines.
Fulminant Meningitis: A Rare Case of HSV-2 and Cryptococcal Co-Infection in a Patient With AIDS.
J Investig Med High Impact Case Rep
October 2024
St. Joseph's University Medical Center, Paterson, NJ, USA.
Article Synopsis
- * The infection starts when cryptococcal spores, often found in bird droppings, are inhaled and can spread to the central nervous system, causing symptoms like headache and cognitive issues.
- * The text also discusses a rare case of fulminant meningitis caused by both herpes simplex virus (HSV)-2 and cryptococcal infection, highlighting the increased mortality risk associated with cryptococcemia.
Kynurenine Pathway after Kidney Transplantation: Friend or Foe?
Int J Mol Sci
September 2024
Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, 6020 Innsbruck, Austria.
Article Synopsis
- * Chronic allograft nephropathy is a major cause of kidney graft rejection despite the use of various immunosuppressive drugs and monitoring techniques.
- * The kynurenine (KYN) pathway, which processes tryptophan, may help modulate immune responses and could play a key role in improving outcomes for kidney transplant patients, prompting research into its implications for immune-related complications.
IgG-immunoadsorptions and eculizumab combination in STEC-hemolytic and uremic syndrome pediatric patients with neurological involvement.
Pediatr Nephrol
September 2024
Pediatric Nephrology, Dialysis and Transplantation Department, Robert Debré University Hospital, APHP, Paris Cité University, Paris, France.
Article Synopsis
- * A retrospective study analyzed 42 pediatric patients treated with either IgIA + ECZ or ECZ alone, alongside a historical cohort receiving supportive care, with focus on survival and neurological outcomes after one year.
- * Results showed no significant survival difference between treatment groups; however, combining IgIA and ECZ did not demonstrate overall benefits for neurological outcomes, suggesting that this combination may only
Neural stem cells derived from α-synuclein-knockdown iPS cells alleviate Parkinson's disease.
Cell Death Discov
September 2024
Neuroscience and Brain Disease Center, College of Medicine, China Medical University, Taichung, 411, Taiwan.
Article Synopsis
- Stem cells can help replace damaged cells and may lead to new treatments for diseases like Parkinson's and Alzheimer's.
- Researchers are using a special type of stem cells called iPS cells that are created from patients' own cells, which is good for both safety and ethics.
- A study showed that using these stem cells to improve the movement and lifespan of mice with a type of Parkinson's disease could be a promising new treatment.
Altered Mental Status in the Solid-Organ Transplant Recipient.
Semin Neurol
December 2024
Department of Neurology, Emory University Hospital, Atlanta, Georgia.
Article Synopsis
- Patients getting organ transplants go through a tough time before and after the surgery, often dealing with serious health issues and needing extra support.
- After the transplant, they might face problems with their thinking or behavior due to brain issues that can last a long time.
- The review talks about different reasons for these brain problems, how to find out what’s wrong, and how to treat them, especially focusing on liver transplant patients but also mentioning other types of transplants.
The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage.
Stem Cell Rev Rep
November 2024
Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Article Synopsis
- Long COVID is associated with serious health complications, including severe lung issues and kidney injury, affecting a significant portion of patients.
- Dental stem cells (DSCs) have potential in regenerative medicine and may help treat tissues affected by COVID-19 due to their unique properties and regenerative capabilities.
- Research is focusing on the beneficial effects of DSC-derived extracellular vesicles (DSC-EVs) in managing COVID-related tissue damage, indicating a promising area for future therapies.
Perioperative Management of Pediatric Combined Heart and Liver Transplantation: A 17 year single center experience.
Paediatr Anaesth
November 2024
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford Children's Hospital, Stanford University Medical Center, Palo Alto, California, USA.
Article Synopsis
- * Eighteen patients, mostly facing Fontan Associated Liver Disease, underwent the complex surgery with median surgical times and significant blood transfusions, highlighting issues like vasoplegia and the use of prothrombin complex concentrates.
- * Post-surgery, patients experienced varying recovery times and complications, including a 30-day thromboembolism rate of 22%, with notable incidences of neurological events and renal issues during the hospital stay.
Long-Term Outcomes of Living Donor Liver Transplantation for Methylmalonic Acidemia.
Pediatr Transplant
September 2024
Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
Article Synopsis
- Scientists studied patients with a rare disease called methylmalonic acidemia (MMA) who had liver transplants to see how well they did over time.
- They found that after 10 years, most of the patients were still alive and doing well, especially if they got their transplant within two years of getting sick.
- However, some patients still had health issues like learning difficulties and kidney problems, but their MMA levels went down a lot after the transplant.
Neurological complications of SARS-CoV-2 infection among solid organ transplanted patients: does immunosuppression matter?
Front Neurol
July 2024
Neurology Service, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), University of Pittsburgh Medical Center Italy (UPMCI), Palermo, Italy.
Article Synopsis
- SARS-CoV-2 infection can cause a wide range of neurological symptoms, from mild issues like headache and fatigue to serious conditions like seizures and encephalitis, with the exact cause still being researched.
- In a study of 73 solid organ transplant recipients who had COVID-19, 74% reported neurological symptoms, particularly myalgia, headache, and altered smell/taste, during and after their infection.
- Factors like oxygen therapy during illness were linked to neurological complications, while pre-existing neurological conditions and specific immunosuppressive drug levels did not significantly impact the likelihood of experiencing these symptoms.
Cryptococcosis at the university hospital of Marseille: A case series.
J Mycol Med
September 2024
IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, Vitrome, Marseille, France.
Article Synopsis
- Cryptococcosis is a serious fungal infection that can be very dangerous, especially for people with weak immune systems, like those with HIV or other health problems.
- A study at the University Hospital of Marseille looked at 15 cases of this infection diagnosed between 2016 and 2022, finding that many patients had other serious health issues, not just HIV.
- The study highlights the importance of quickly identifying and treating cryptococcosis to help patients survive, especially since some warning signs may be missed by doctors.
Emerging shadows: HHV-8-associated encephalitis unveiled in a solid organ transplant recipient.
Transpl Infect Dis
August 2024
Section of Infectious Diseases, UT Health McGovern Medical School, Houston, Texas, USA.
Article Synopsis
- Human herpesviruses (HHVs) can cause serious brain infections like meningitis and encephalitis.
- HHV-8, usually not linked to brain issues, was found to cause encephalitis in a patient who had just received an organ transplant and had a related disease called Kaposi's Sarcoma.
- The patient was treated with special antiviral medicine, showing that it's important for doctors to be aware of HHV-8 risks in transplant patients.
Tacrolimus-induced posterior reversible encephalopathy syndrome following liver transplantation.
World J Transplant
June 2024
Division of Gastroenterology and Hepatology, East Carolina University/Brody School of Medicine, Greenville, NC 27858, United States.
Article Synopsis
- The editorial discusses a condition called posterior reversible encephalopathy syndrome (PRES) that can happen to people who have had liver transplants and are treated with a medicine called Tacrolimus.
- Tacrolimus helps prevent the body from rejecting the new liver, but it can cause problems like PRES, which leads to symptoms like high blood pressure, seizures, and vision issues.
- The article emphasizes that doctors need to recognize and diagnose PRES early to help patients feel better and manage the risks from using Tacrolimus.
Liver transplantation for Wilson disease: Current knowledge and future perspectives.
Liver Transpl
December 2024
Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
Liver transplantation currently represents a therapeutic option for patients with Wilson disease presenting with end-stage liver disease or acute liver failure. Indeed, it has been associated with excellent postoperative survival curves in view of young age at transplant and absence of recurrence. Attention has shifted over the past decades to a wise expansion of indications for liver transplantation.
View Article and Find Full Text PDFArticle Synopsis
- A study was done to see if cooling down organ donors could help transplant kidneys work better after they are given to patients, especially since some donors have a higher risk of complications.* -
- The research involved hospitals in France and focused on older donors or those with health issues, randomly putting some in a cooler state and others in a normal temperature.* -
- The main goal was to find out how many kidney recipients needed extra help with their kidneys within the first week after the transplant and looked at other health measures for both donors and recipients.*