3,015 results match your criteria: "Neuroleptic Malignant Syndrome"
The limited clinical utility of a routine creatine kinase (CK) on admission to a psychiatric inpatient unit.
BMC Psychiatry
December 2024
South London and Maudsley NHS Foundation Trust, London, UK.
Background: Creatine kinase (CK) is an intracellular enzyme expressed most commonly in tissues such as skeletal muscle. CK can be used as an investigation to support the diagnosis of conditions such as neuroleptic malignant syndrome (NMS), a rare idiosyncratic drug reaction - classically to antipsychotic medications - which can be fatal. Routine screening of CK in psychiatric inpatients is a known practice, but its value is uncertain.
View Article and Find Full Text PDFDiagnostic Challenges in Malignant Hyperthermia and Anesthesia-Induced Rhabdomyolysis: A Case Study.
Am J Case Rep
December 2024
Department of Surgery, Medical University of Sofia, University Hospital "Queen Giovanna - ISUL", Sofia, Bulgaria.
BACKGROUND Malignant hyperthermia (MH) and anesthesia-induced rhabdomyolysis (AIR) are rare, yet life-threatening complications that need prompt therapeutic actions and logistic preparedness for treatment success. Both conditions are triggered by general anesthetics, particularly volatiles and depolarizing muscle relaxants. In comparison with MH, which is an inherited pharmacogenomic disease of calcium channel receptor subpopulation and arises only after trigger exposure, AIR has been described mostly in patients with muscular dystrophies.
View Article and Find Full Text PDFInflammation-Related Non-Infectious Febrile Reaction Induced by Electroconvulsive Therapy in a Young Female with Bipolar Disorder: A Case Report and Literature Review.
Psychiatry Clin Psychopharmacol
November 2024
Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial, Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Article Synopsis
- Electroconvulsive therapy (ECT) is an effective treatment for persistent psychiatric disorders, though post-ECT fever is rare and not widely reported.
- A case study of a 27-year-old woman with bipolar disorder showed she experienced multiple fever episodes after ECT, with diagnostic tests indicating inflammation but no signs of infection or serious syndromes.
- The findings suggest that the fever may be a benign inflammatory response to ECT, allowing for the continued use of ECT to achieve therapeutic benefits.
Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data.
Eur Child Adolesc Psychiatry
December 2024
Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.
Article Synopsis
- Clozapine use is primarily associated with the risk of neutropenia, but there is limited research on adverse drug reactions (ADRs) and fatal outcomes in patients under 18 years old.
- A study analyzed 2,825 reports of clozapine usage in this age group, revealing 42 fatal outcomes, with the most common ADR being decreased white blood cell count, while suicide was a significant cause of non-duplicated fatalities.
- To better prevent fatal outcomes in young patients, child and adolescent psychiatrists should broaden their focus beyond severe neutropenia to include other serious ADRs like pneumonia, while still being cautious of the risk of overdose in those at risk for suicide.
Lamotrigine as a preventive agent against recurrent catatonia in adult-onset Niemann-Pick Type-C disease: a case report.
Neurocase
December 2024
Department of Psychiatry, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Article Synopsis
- - Niemann-Pick Type-C (NPC) disease can lead to serious neuropsychiatric issues, including catatonia, which doesn't always respond well to standard treatments like antipsychotics.
- - A patient with adult-type NPC developed catatonia that persisted despite various medications, but improved significantly with electroconvulsive therapy (ECT).
- - Combining ECT with lorazepam managed the catatonia, and adding lamotrigine led to full remission for eight months, suggesting lamotrigine's potential benefits in treating recurrent catatonia.
Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database.
Braz J Psychiatry
November 2024
Jiangsu Medical College, Yancheng, Jiangsu, China. Sheyang Hospital of Traditional Chinese Medicine, Yancheng, Jiangsu, China.
Article Synopsis
- - The study evaluates the safety of Olanzapine by analyzing adverse events reported in the FAERS database from 2004 to mid-2023, highlighting newly identified risks.
- - Using four signal mining methods, the analysis reviewed 43,664 reports, revealing 776 signals related to adverse effects, primarily affecting females aged 18-45, with psychiatric and nervous system disorders being the most common issues.
- - The research uncovered new cardiovascular risks associated with Olanzapine, such as pancreatitis and myocardial reperfusion injury, suggesting that these findings necessitate further investigation.
The broad spectrum of malignant syndromes.
Neurobiol Dis
December 2024
Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy; IRCCS Neuromed Institute, Via Atinense 18, 86077 Pozzilli, (IS), Italy. Electronic address:
Article Synopsis
- - Malignant syndromes are serious medical conditions that develop rapidly and can lead to life-threatening complications if not treated promptly.
- - These syndromes share similar clinical features and mechanisms, affecting various neurotransmitter systems, which highlight the need for urgent medical attention.
- - Understanding the clinical aspects and underlying causes of malignant syndromes is crucial for effective management and reducing the risks of severe health consequences.
Neuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium.
AJP Rep
July 2024
Division of Neonatology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.
Article Synopsis
- - Atypical antipsychotics are increasingly used in the NICU to manage neonatal delirium, but caution is needed due to potential adverse effects like neuroleptic malignant syndrome (NMS).
- - NMS is a rare but serious reaction to antipsychotics, primarily seen in older children, but this case report highlights its occurrence in a 10-month-old infant treated with olanzapine.
- - Symptoms of NMS include hyperthermia and mental status changes, emphasizing the need for careful monitoring and management when prescribing antipsychotics to infants.
Anti-NMDAR Encephalitis developing neuroleptic malignant syndrome.
Ind Psychiatry J
August 2024
Department of Psychiatry, Armed Forces Medical College, Pune, Maharashtra, India.
Use of Electroconvulsive Therapy on an Adolescent Inpatient Psychiatric Unit.
Child Adolesc Psychiatr Clin N Am
January 2025
Department of Psychiatry and Behavioral Neurobiology, The University of Alabama at Birmingham, 240C Center for Psychiatric Medicine| 1713 6th Avenue South, Birmingham, AL 35233, USA.
Article Synopsis
- Electroconvulsive therapy (ECT) is highlighted as a safe and effective treatment for psychiatric disorders in kids and teens, particularly for severe cases.
- The text discusses ECT's history, legal and ethical aspects, common uses (like treatment-resistant mood disorders), and the importance of thorough medical evaluations before beginning treatment.
- Informed consent from both the patient and their parents is essential, ensuring that the patient understands and agrees to the procedure.
Neuroleptic malignant syndrome in Huntington disease.
Eur J Neurol
December 2024
Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
Article Synopsis
- A study evaluated the prevalence of neuroleptic malignant syndrome (NMS) in Huntington disease (HD) patients, finding that it is rarely reported despite the use of dopamine receptor blocking agents (DRBAs).
- Researchers reviewed patient data and case literature to assess NMS occurrences in a cohort of HD patients treated with DRBAs and tetrabenazine (TBZ).
- Results indicated only one diagnosed case of NMS among 5,108 patients, suggesting underreporting and highlighting critical risk factors like advanced disease stage and medication management issues.
Bipolar Disorder in a Young Adult With Thalassemia Major With Sequential Development of Neuroleptic Malignant Syndrome and Serotonin Syndrome.
J Clin Psychopharmacol
October 2024
Department of Psychiatry, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India
Expert guidance on the differential diagnosis of neuroleptic malignant syndrome.
Expert Rev Neurother
October 2024
Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, Ancona, Italy.
Acute kidney injury induced lithium toxicity with concomitant neuroleptic malignant syndrome.
Biomedicine (Taipei)
September 2024
Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia.
Article Synopsis
- Lithium is crucial for treating psychiatric disorders but has a narrow therapeutic index, requiring careful monitoring.
- A case study reveals a 50-year-old man with bipolar disorder who developed chronic lithium toxicity and neuroleptic malignant syndrome (NMS) after dehydration from a viral illness, complicating his treatment.
- Recovery involved fluid therapy and supportive care, leading to a successful discharge with a lower potency medication and gradual dose adjustments.
A Case of Neuroleptic Malignant Syndrome-Prompted Myoglobin Cast Nephropathy.
Indian J Nephrol
June 2023
Department of Nephrology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India.
Article Synopsis
- - Myoglobin cast nephropathy occurs after rhabdomyolysis, leading to myoglobin release that damages kidney tubules and causes blockages.
- - The case discussed involves a patient taking neuroleptic drugs who developed neuroleptic malignant syndrome, a serious reaction often caused by these medications.
- - This patient also experienced acute kidney injury due to the complications from myoglobin cast nephropathy related to their condition.
Psychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry.
Semin Neurol
December 2024
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Article Synopsis
- - Consultation liaison psychiatrists are often called to assess patients with altered mental status (AMS), where they apply their specialized skills to enhance care and prevent diagnostic overshadowing.
- - Delirium is the most common cause of AMS, but psychiatrists also consider other conditions like manic and psychotic episodes, which can have overlapping symptoms.
- - A comprehensive and nonstigmatizing evaluation approach for AMS, including factors like substance intoxication and withdrawal, is crucial for improving patient outcomes and experiences.
Evaluation of Antipsychotic-Induced Neuroleptic Malignant Syndrome Using a Self-Organizing Map.
Cureus
August 2024
Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, JPN.
Article Synopsis
- * The researchers utilized a self-organizing map (SOM) and decision tree analysis to differentiate between 31 antipsychotics, revealing detailed NMS profiles beyond the usual classifications of typical and atypical antipsychotics.
- * The study analyzed 887,704 reports from the Japanese Adverse Drug Event Report database, providing valuable insights on NMS occurrences with specific antipsychotics to help healthcare providers better manage schizophrenia treatment.
Rhythmic Delta Activity Beyond Neuroleptic Malignant Syndrome.
Intern Med
September 2024
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.
Long-Acting Injectable Antipsychotic Medication Use in Youth: A Systematic Review of the Literature Along with MedWatch Safety Data and Prescriber Attitudes.
J Child Adolesc Psychopharmacol
September 2024
Winnebago Mental Health Institute, Winnebago, Wisconsin, USA.
Article Synopsis
- Long-acting injectable (LAI) antipsychotic medications are being prescribed to children aged 2 to 17, but there are no FDA-approved options specifically for this age group.
- A systematic literature review and survey of psychiatrists were conducted to gather safety data and understand attitudes towards LAI use in youth, revealing that most studies favored LAIs despite their low quality.
- While concerns about safety exist—particularly regarding serious side effects like extrapyramidal symptoms—LAIs may still be beneficial for treating severe psychiatric symptoms and improving treatment adherence in selected pediatric patients.
Neuroleptic Malignant Syndrome.
N Engl J Med
September 2024
From the Neurosciences Intensive Care Unit, Mayo Clinic Hospital, Rochester, MN (E.F.M.W.).
Dual Toxidrome of Anti-cholinergic Storm and Neuroleptic Malignant Syndrome: A Therapeutic Challenge Overcome by Intrathecal Neostigmine.
Neurohospitalist
October 2024
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Article Synopsis
- Anticholinergic toxicity and neuroleptic malignant syndrome (NMS) are both serious conditions that can occur together, but this combination is rare and complicated to treat.* * A 23-year-old male with a history of substance dependence was admitted due to toxicity from both trihexyphenidyl and risperidone, leading to a diagnosis of dual toxidrome.* * Treatment involved medications like lorazepam and bromocriptine for NMS, while intrathecal neostigmine was used as an alternative when the preferred antidote, physostigmine, wasn't available; the patient eventually recovered.*
Neuroleptic Malignant Syndrome with Low-dose Quetiapine After Venlafaxine Withdrawal: A Case Report.
Turk Psikiyatri Derg
September 2024
Article Synopsis
- * A case report describes a 40-year-old man who developed NMS after withdrawing from venlafaxine while taking a low dose of quetiapine, suggesting that withdrawal may be a contributing factor in NMS cases.
- * This case highlights the importance of recognizing the risk of NMS even at low doses of quetiapine in patients without known risk factors, emphasizing the need for careful monitoring and prompt diagnosis.
Incidence of Neuroleptic Malignant Syndrome During Antipsychotic Treatment in Children and Youth: A National Cohort Study.
J Child Adolesc Psychopharmacol
November 2024
Departments of Pediatrics and Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Article Synopsis
- A study examined the incidence of neuroleptic malignant syndrome (NMS), a serious side effect of antipsychotics, in young people aged 5-24 and found that there were 131 NMS cases among over a million patients during the study period (2004-2013).
- The incidence of NMS was significantly higher in patients exhibiting certain characteristics, including being 18-24 years old, having schizophrenia or other psychotic disorders, neurodevelopmental disorders, using first-generation antipsychotics, or taking doses over 200 mg chlorpromazine-equivalents.
- The results suggest that patients with 4-5 of these risk factors faced over 100 times the risk of developing NMS compared to
Not Too Rare to Matter: The Incidence of Neuroleptic Malignant Syndrome in Children and Adolescents Treated with Antipsychotics.
J Child Adolesc Psychopharmacol
November 2024
Department of Behavioral Science & Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, USA.
Widespread Muscle Calcification due to Neuroleptic Malignant Syndrome.
Intern Med
September 2024
Emergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Japan.