35,087 results match your criteria: "Neural Tube Defects"
J Med Case Rep
December 2024
Department of Neurosurgery, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Background: Giant prolactinoma (size > 4 cm) is a rare condition and accounts for less than 1% of pituitary adenomas. In even rarer cases, these lesions may involve craniocervical structures requiring surgical intervention. The present case is the largest reported giant prolactinoma (99 × 72 × 57 mm).
View Article and Find Full Text PDFPak J Med Sci
December 2024
Muhammad Aqeel Natt, MBBS, FCPS (Neurosurgery), Department of Neurosurgery Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan.
Encephalocele is a congenital neural tube defect (NTD). The pathophysiology of the NTDs is exceedingly complex. Numerous explanations have been proposed to explain it.
View Article and Find Full Text PDFBMC Urol
December 2024
Department of Pediatric Surgery, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Türkiye, Turkey.
Introduction: Spina bifida is a condition that impacts the development of the neural tube leading to urological and gastrointestinal symptoms. Both systems are influenced together due to their shared innervation and embryological origin. Despite its impact on health and well-being there has been limited research on the relationship between manometry results and urodynamic tests, in this patient population.
View Article and Find Full Text PDFNutr Health
December 2024
Biology and Environmental Science Department, University of New Haven, West Haven, CT, USA.
Folic acid (FA) supplementation is widely regarded as a key nutritional intervention during pregnancy due to its protective effect against neural tube defects. Recent research has reported FA supplementation outcomes on offspring's health, with increased incidences of allergy/respiratory problems. This study evaluates if increased levels of 5-methyltetrahydrofolate (5-MTHF) are associated with DNA modification, leading to disruption of cell proliferation in fetal lung cells and increasing susceptibility to asthma.
View Article and Find Full Text PDFFront Toxicol
December 2024
National Center for Toxicological Research (FDA), Division of Systems Biology, Jefferson, AR, United States.
Introduction: In 2015, the FDA released a Drug Safety Communication regarding a possible link between opioid exposure during early pregnancy and an increased risk of fetal neural tube defects (NTDs). At the time, the indications for opioid use during pregnancy were not changed due to incomplete maternal toxicity data and limitations in human and animal studies. To assess these knowledge gaps, largescale animal studies are ongoing; however, state-of-the-art technologies have emerged as promising tools to assess otherwise non-standard endpoints.
View Article and Find Full Text PDFAnal Bioanal Chem
December 2024
State Key Laboratory of Medical Proteomics, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Folate, serving as a crucial micronutrient, plays an important role in promoting human growth and supporting transformations to a variety of metabolic pathways including one-carbon, pyrimidine, purine, and homocysteine metabolism. The 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme is pivotal in the folate metabolic pathway. Polymorphism in the MTHFR gene, especially C677T, was associated with decreased enzyme activity and disturbance of folate metabolism, which is linked to various diseases including birth defects in newborns and neural tube abnormalities.
View Article and Find Full Text PDFPlacenta
December 2024
Health Sciences, Carleton University, Ottawa, ON, K1S 5B6, Canada. Electronic address:
Introduction: Spina bifida (SB) remains one of the most common congenital anomalies and associates with significant comorbidities in the fetus, which may, in part, be driven by placental maldevelopment. We hypothesised that placental pathologies would be more prevalent in fetuses with SB compared to fetuses without congenital anomalies.
Methods: Placental pathology and transcriptome were evaluated for fetuses with isolated open SB born preterm (cases; n = 12) and control fetuses without congenital anomalies (n = 22) born at full term (FT) or preterm (PT).
Adv Sci (Weinh)
December 2024
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Integrated biochemical and biophysical signals regulate embryonic development. Correct neural tube formation is critical for the development of central nervous system. However, the role of microgravity in neurodevelopment and its underlying molecular mechanisms remain unclear.
View Article and Find Full Text PDFMatern Child Nutr
December 2024
Department of Nutrition and Institute for Global Nutrition, University of California, Davis, California, USA.
There is a high incidence of neural tube defects (NTDs) in Ethiopia and folate insufficiency, a primary risk factor for NTDs, is common among Ethiopian women of reproductive age (WRA). Folic acid fortification of salt has been proposed as a strategy to control these problems. In preparation for an intervention trial to assess the nutritional effects of folic acid-fortified salt, we measured discretionary salt intakes among nonpregnant WRA using observed weighed food records, and we assessed household salt disappearance rates.
View Article and Find Full Text PDFChilds Nerv Syst
December 2024
Department of Neurosurgery, Izmir Tinaztepe University, Faculty of Medicine, Izmir, Turkey.
Purpose: Tethered cord syndrome (TCS) typically presents with urologic symptoms and abnormal imaging findings. However, some patients present with normal conus medullaris level and filum terminale appearance on MRI. This research seeks to assess the intended surgical results in this particular group of TCS patients who do not present with urologic complaints, under the premise that the surgical approach goes a long way in preventing the onset of urologic abnormalities.
View Article and Find Full Text PDFGenet Med Open
September 2024
Center for Neurogenetics, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.
Purpose: Spina bifida (SB) arises from complex genetic interactions that converge to interfere with neural tube closure. Understanding the precise patterns conferring SB risk requires a deep exploration of the genomic networks and molecular pathways that govern neurulation. This study aims to delineate genome-wide regulatory signatures underlying SB pathophysiology.
View Article and Find Full Text PDFInfect Dis Ther
December 2024
ViiV Healthcare, 980 Great West Road, Brentford, Middlesex, TW8 9GS, UK.
Lowering viral load during pregnancy is regarded as the most important method of reducing human immunodeficiency virus 1 (HIV-1) vertical transmission risk, and minimizing fetal exposure to drugs is a guiding principle during pregnancy. Dolutegravir/lamivudine (DTG/3TC) has demonstrated high efficacy, a high barrier to resistance, and a good safety profile in non-pregnant individuals; however, DTG/3TC is not recommended by perinatal HIV treatment guidelines for initial therapy in pregnant people living with HIV-1 because of limited data on use of the 2-drug regimen during pregnancy. Efficacy and pharmacokinetic data from pregnant individuals using DTG and/or 3TC are reviewed and used to extrapolate anticipated DTG/3TC efficacy in pregnancy.
View Article and Find Full Text PDFJ Matern Fetal Neonatal Med
December 2025
University of Cincinnati Medical College of Medicine, Cincinnati, OH, USA.
Stem Cell Res Ther
December 2024
Center for Precision Environmental Health, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
J Med Case Rep
December 2024
Department of Obstetrics and Gynecology, Nekemte Specialized Hospital, Nekemte City, Oromia Regional State, Ethiopia.
Objectives: Conjoined twins are described as having been physically fused during pregnancy and delivery. They share some vital organs, such as the heart, lungs, liver, abdomen, etc. The article aims to present a unique discussion on conjoined twins at the abdomen, with twin A with anencephaly and face presentation and twin B with cephalic presentation.
View Article and Find Full Text PDFPoult Sci
November 2024
Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agricultural, Food, and Environmental Sciences, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel. Electronic address:
Hatchability rates in broilers pose a significant challenge in the poultry industry. Despite advancements in breeding and incubation technology, hatch rates remain suboptimal due to factors like genetics, egg management, environmental stress, nutrition, and breeder age. Understanding the mechanisms behind compromised hatchability is crucial for improving broiler production.
View Article and Find Full Text PDFA A Pract
December 2024
From the Department of Anesthesiology, Uniformed Services University, Bethesda, Maryland.
Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics.
View Article and Find Full Text PDFInt J Dev Neurosci
December 2024
Department of Pediatric Surgery, Hangzhou Children's Hospital, Zhejiang, Hangzhou, China.
Childs Nerv Syst
December 2024
Division of Neurosurgery, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Split notochord syndrome (SNS) is a rare congenital anomaly characterized by incomplete midline notochordal integration during gastrulation, leading to segmental clefts of the spine. This case report describes a female patient with symptomatic cervico-dorsal SNS associated with a neurenteric cyst (NEC), intrathoracic gut duplication, and secondary hydrocephalus. Multistep surgical interventions were performed, including hydrocephalus management, excision of the cyst and gut duplication, and detethering with sectioning of the filum.
View Article and Find Full Text PDFBMC Pediatr
December 2024
College of Nursing and Mo-Im Kim Nursing Research Institute, Yonsei University, Seoul, South Korea.
Background: Spina bifida (SB) is a chronic condition requiring lifelong self-management, underscoring the need to establish a dedicated cohort for longitudinal monitoring of health outcomes. The purpose of this study was to describe the development and initial implementation of a single-center prospective cohort study of children with SB and their parents living in South Korea and to describe demographics, clinical outcomes, psychosocial characteristics, and family data for this cohort.
Methods: This cohort was established through expert panel formation, identification of health indicators based on the Life Course Model for Spina Bifida, creation of a cohort database system, and quality control planning.
Childs Nerv Syst
November 2024
Department of Neurosurgery, Birmingham Women and Children's NHS Foundation Trust, Birmingham, UK.
Purpose: A review of intraoperative neuromonitoring (IONM) and mapping (IONMa) utility during paediatric tethered cord surgery with particular attention to feasibility, measures to prevent injury, and postoperative outcome.
Methods: A retrospective analysis of spinal cord untethering surgery between 2015 and 2022 was carried out. Cohort demographics, IONM and IONMa data, and procedural details were summarised and associations between variables explored.
Clin Neurol Neurosurg
January 2025
Departments of Orthopaedic Surgery and Neurological Surgery, Duke University Health System, Durham, NC, USA. Electronic address:
Objective: This study investigated the response and readability of generative artificial intelligence (AI) models to questions and recommendations proposed by the 2023 Congress of Neurological Surgeons (CNS) guidelines for Chiari 1 malformation.
Methods: Thirteen questions were generated from CNS guidelines and asked to Perplexity, ChatGPT 4o, Microsoft Copilot, and Google Gemini. AI answers were divided into two categories, "concordant" and "non-concordant," according to their alignment with current CNS guidelines.
Public Health Nutr
November 2024
Centre for Human Metabolomics, North-West University, Potchefstroom, North-West Province, South Africa.
Objective: Neural tube defects (NTD) are serious, life-threatening birth defects. Staple food fortification with folic acid (vitamin B) is a proven, effective intervention to reduce NTD birth prevalence. Mandatory food fortification with folic acid was implemented in South Africa (SA) in 2003.
View Article and Find Full Text PDFZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2024
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing100730, China.
To analyze the efficacy of endoscopic surgery for frontal sinus meningoencephalocele and cerebrospinal fluid (CSF) leaks, and to explore endoscopic surgical strategy. A total of 35 patients with frontal sinus meningoencephalocele and CSF leaks who underwent endoscopic transnasal surgery at Beijing Tongren Hospital, Capital Medical University between May 2007 and December 2023 were enrolled in this retrospective case series, including 29 males and 6 females, with the age of (35.23±15.
View Article and Find Full Text PDFSci Rep
November 2024
Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, 101 Daehak- ro, Jongno-gu, Seoul, 03080, Republic of Korea.