Hypermelanocytic guttate and macular segmental hypomelanosis.

We report two sisters, 27 and 30 years of age, with a cutaneous pigmentary anomaly, which seems to be a new entity. At the age of 26 years the elder sister developed an asymptomatic and persistent rash consisting of discrete, grouped, round to oval, guttate and nummular, hypopigmented macules, 0.2-5 cm in diameter.

Vitiligo management update.

Vitiligo is an acquired skin disorder caused by the disappearance of pigment cells from the epidermis, and results in well defined white patches that are often symmetrically distributed. The lack of melanin pigment makes the lesional skin more sensitive to sunburn. Vitiligo can be cosmetically disfiguring and is a stigmatizing condition, leading to serious psychological problems in daily life.

Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser.

Background: Monobenzylether of hydroquinone is used worldwide to remove residual pigment in patients with vitiligo universalis. Because of the side effects reported with this drug, the use of monobenzylether of hydroquinone has been restricted in The Netherlands.

Objective: Our purpose was to evaluate the long-term effectiveness and safety of a combination therapy consisting of topical 4-methoxyphenol (4-MP) cream and Q-switched ruby (QSR) laser in 16 patients with vitiligo universalis.

Treatment of generalized vitiligo in children with narrow-band (TL-01) UVB radiation therapy.

Background: Only a few clinical trials have been performed on the treatment of generalized vitiligo in children. Recently, narrow-band UVB therapy has been reported to be an effective and safe therapeutic option in adult patients with vitiligo.

Objective: We studied the efficacy and safety of UVB (311 nm) therapy in children with generalized vitiligo and evaluated the effect of the therapy on the quality of life in these children.

The development of guidelines for the treatment of vitiligo. Clinical Epidemiology Unit of the Istituto Dermopatico dell'Immacolata-Istituto di Recovero e Cura a Carattere Scientifico (IDI-IRCCS) and the Archives of Dermatology.

Objective: To develop and introduce evidence-based guidelines for the treatment of vitiligo in children and in adults.

Patients And Setting: Patients, residents, and dermatologists from the Department of Dermatology, Academic Medical Center, University of Amsterdam, and the Netherlands Institute for Pigmentary Disorders in Amsterdam.

Design: Scientific evidence obtained from 3 systematic reviews of the literature was combined with the results of 2 questionnaires and interviews of potential users of the guidelines, 3 internal expert meetings, and 1 local expert meeting, during which preliminary guidelines were presented and commented on.

Management of vitiligo. Results of a questionnaire among dermatologists in The Netherlands.

Background: Several therapeutic options are available for the treatment of vitiligo. Concern exists that there is no uniform approach towards the management of vitiligo among Dutch dermatologists.

Methods: A written survey concerning the management of vitiligo was sent to 332 dermatologists in The Netherlands.

Association of the Köbner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris.

Objective: To investigate the association between the experimentally induced Kobner phenomenon (KP-e) and the Kobner phenomenon by history (KP-h), disease activity, and therapeutic responsiveness in vitiligo vulgaris.

Design: Cohort study.

Setting: An outpatient clinic.

Repigmentation of leucodermic defects in piebaldism by dermabrasion and thin split-thickness skin grafting in combination with minigrafting.

The depigmented skin areas in piebaldism are unresponsive to medical or light treatment. In 12 adult patients (eight women and four men), a method using dermabrasion and thin split-skin grafts was applied initially. Residual leucodermic areas were subsequently treated using a minigrafting method.

A systematic review of autologous transplantation methods in vitiligo.

Objective: A systematic review of the effectiveness, safety, and applicability of autologous transplantation methods in vitiligo.

Data Sources: Computerized searches of bibliographical databases, a complementary manual literature search, and contacts with researchers and pharmaceutical firms.

Study Selection: Predefined selection criteria were applied to all studies found.

Nonsurgical repigmentation therapies in vitiligo. Meta-analysis of the literature.

Objective: To assess the effectiveness and safety of nonsurgical repigmentation therapies in localized and generalized vitiligo by means of a meta-analysis.

Data Sources: Computerized searches of bibliographic databases, a complementary manual literature search, and contacts with researchers and pharmaceutical firms.

Study Selection: Predefined selection criteria were applied to both randomized and nonrandomized controlled trials.

Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A.

Objective: To compare the efficacy and safety of 2 treatment modalities, topical psoralen plus UV-A (PUVA) with unsubstituted psoralen and 311-nm UV-B radiation, in patients with vitiligo.

Design: This intervention study was designed as a before-and-after trial with 2 arms, in which patients were consecutively included.

Patients: Male (n = 99) and female (n = 182) patients, who predominantly had skin type III, with extensive, generalized vitiligo of more than 3 months' duration.

Laser treatment for further depigmentation in vitiligo.

Background: In patients with vitiligo, sometimes the greatest part of the skin has already lost its melanocytes. The remaining pigmented patches can be removed by using strong bleaching creams, but many adverse events have been reported with this treatment. A new depigmentation therapy could be treatment with a Fluby laser.