21 results match your criteria: "Netherlands Institute for Neuroscience Amsterdam[Affiliation]"
J Physiol
December 2023
Netherlands Institute for Neuroscience Amsterdam, Amsterdam, the Netherlands.
In Nyx mice, a model for congenital nystagmus associated with congenital stationary night blindness (CSNB), synchronous oscillating retinal ganglion cells (RGCs) lead to oscillatory eye movements, i.e. nystagmus.
View Article and Find Full Text PDFFront Ophthalmol (Lausanne)
June 2023
Department of Cerebellum: Coordination & Cognition, Netherlands Institute for Neuroscience Amsterdam, Amsterdam, Netherlands.
Congenital nystagmus is a condition where the eyes of patients oscillate, mostly horizontally, with a frequency of between 2 and 10 Hz. Historically, nystagmus is believed to be caused by a maladaptation of the oculomotor system and is thus considered a disease of the brain stem. However, we have recently shown that congenital nystagmus associated with congenital stationary night blindness is caused by synchronously oscillating retinal ganglion cells.
View Article and Find Full Text PDFInt J Mol Sci
March 2022
Netherlands Institute for Neuroscience Amsterdam, 1105 BA Amsterdam, The Netherlands.
Patients with congenital nystagmus, involuntary eye movements, often have a reduced visual acuity. Some of these patients have a retinal-specific mutation in the protein nyctalopin, which is also present in the mouse. In these mice, retinal ganglion cells (RGCs) have oscillatory activity, which leads to expanded axonal projections towards the dLGN and consequently to a desegregation of retinal projections to the brain.
View Article and Find Full Text PDFBackground We previously showed that intracranial aneurysm ( IA )-associated single-nucleotide polymorphisms are enriched in promoters and putative enhancers identified in the human circle of Willis, on which IA s develop, suggesting a role for promoters and enhancers in IAs . We further investigated the role of putative enhancers in the pathogenesis of IA by identifying their potential target genes and validating their regulatory activity. Methods and Results Using our previously published circle of Willis chromatin immunoprecipitation and sequencing data, we selected 34 putative enhancers in IA -associated regions from genome-wide association studies.
View Article and Find Full Text PDFObjective: We aimed to study the occurrence and development of axonal pathology and the influence of astrocytes in vanishing white matter.
Methods: Axons and myelin were analyzed using electron microscopy and immunohistochemistry on and single- and double-mutant mice and patient brain tissue. In addition, astrocyte-forebrain co-culture studies were performed.
Front Neural Circuits
September 2016
Synapse and Network Development, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
In order to accurately process incoming sensory stimuli, neurons must be organized into functional networks, with both genetic and environmental factors influencing the precise arrangement of connections between cells. Teasing apart the relative contributions of molecular guidance cues, spontaneous activity and visual experience during this maturation is on-going. During development of the sensory system, the first, rough organization of connections is created by molecular factors.
View Article and Find Full Text PDFFront Cell Neurosci
October 2015
Atomic Force Microscopy and Nanotechnology Laboratories, Department of Neurobiology, Center for Glial Biology in Medicine, Civitan International Research Center, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham Birmingham, AL, USA.
Front Mol Neurosci
August 2015
Department of Neuroregeneration, Netherlands Institute for Neuroscience Amsterdam, Netherlands ; Center for Neurogenomics and Cognition Research, Neuroscience Campus Amsterdam Amsterdam, Netherlands.
Clinical phase I/II studies have demonstrated the safety of gene therapy for a variety of central nervous system disorders, including Canavan's, Parkinson's (PD) and Alzheimer's disease (AD), retinal diseases and pain. The majority of gene therapy studies in the CNS have used adeno-associated viral vectors (AAV) and the first AAV-based therapeutic, a vector encoding lipoprotein lipase, is now marketed in Europe under the name Glybera. These remarkable advances may become relevant to translational research on gene therapy to promote peripheral nervous system (PNS) repair.
View Article and Find Full Text PDFFront Cell Neurosci
July 2015
Cerebellar Coordination and Cognition, Netherlands Institute for Neuroscience Amsterdam, Netherlands ; Department of Neuroscience, Erasmus MC Rotterdam, Netherlands.
Just as there is a huge morphological and functional diversity of neuron types specialized for specific aspects of information processing in the brain, astrocytes have equally distinct morphologies and functions that aid optimal functioning of the circuits in which they are embedded. One type of astrocyte, the Bergmann glial cell (BG) of the cerebellum, is a prime example of a highly diversified astrocyte type, the architecture of which is adapted to the cerebellar circuit and facilitates an impressive range of functions that optimize information processing in the adult brain. In this review we expand on the function of the BG in the cerebellum to highlight the importance of astrocytes not only in housekeeping functions, but also in contributing to plasticity and information processing in the cerebellum.
View Article and Find Full Text PDFFront Behav Neurosci
June 2015
Department of Cognitive Neuroscience, Maastricht University Maastricht, Netherlands ; Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
Background: Spider phobics show an exaggerated fear response when encountering spiders. This fear response is aggravated by negative and irrational beliefs about the feared object. Cognitive reappraisal can target these beliefs, and therefore has a fear regulating effect.
View Article and Find Full Text PDFFront Neurosci
April 2015
Cortical Structure and Function Group, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
Front Neurosci
March 2015
Department of Genetics, Genomics and Informatics, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center Memphis, TN, USA.
Front Neurosci
December 2014
Cortical Structure and Function Group, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social interaction and communication, and restricted behavior and interests. A disruption in the balance of excitatory and inhibitory neurotransmission has been hypothesized to underlie these disorders. Here we demonstrate that genes of both pathways are affected by ASD, and that gene expression of inhibitory and excitatory genes is altered in the cerebral cortex of adult but not younger autistic individuals.
View Article and Find Full Text PDFFront Cell Neurosci
November 2014
Laboratory for Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience Amsterdam, Netherlands ; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam Amsterdam, Netherlands.
Traumatic injury of the central nervous system (CNS) has severe impact on the patients' quality of life and initiates many molecular and cellular changes at the site of insult. Traumatic CNS injury results in direct damage of the axons of CNS neurons, loss of myelin sheaths, destruction of the surrounding vascular architecture and initiation of an immune response. Class III semaphorins (SEMA3s) are present in the neural scar and influence a wide range of molecules and cell types in and surrounding the injured tissue.
View Article and Find Full Text PDFFront Neuroanat
September 2014
Cortical Structure and Function Group, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
Calretinin is a calcium-binding protein often used as a marker for a subset of inhibitory interneurons in the mammalian neocortex. We studied the labeled cells in offspring from a cross of a Cre-dependent reporter line with the CR-ires-Cre mice, which express Cre-recombinase in the same pattern as calretinin. We found that in the mature visual cortex, only a minority of the cells that have expressed calretinin and Cre-recombinase during their lifetime is GABAergic and only about 20% are immunoreactive for calretinin.
View Article and Find Full Text PDFBrain Behav
July 2014
Netherlands Institute for Neuroscience Amsterdam ZO, 1105 BA, The Netherlands.
Background: The human hypothalamus contains the neuropeptide FF (NPFF) neurochemical network. Animal experiments demonstrated that NPFF is implicated in the central cardiovascular regulation. We therefore studied expression of this peptide in the hypothalamus of individuals who suffered from essential hypertension (n = 8) and died suddenly due to acute myocardial infarction (AMI), and compared to that of healthy individuals (controls) (n = 6) who died abruptly due to mechanical trauma of the chest.
View Article and Find Full Text PDFFront Microbiol
August 2014
Institute for Systems Biology Seattle, WA, USA ; Luxembourg Centre for Systems Biomedicine, University of Luxembourg Esch-sur-Alzette, Luxembourg.
Living organisms persist by virtue of complex interactions among many components organized into dynamic, environment-responsive networks that span multiple scales and dimensions. Biological networks constitute a type of information and communication technology (ICT): they receive information from the outside and inside of cells, integrate and interpret this information, and then activate a response. Biological networks enable molecules within cells, and even cells themselves, to communicate with each other and their environment.
View Article and Find Full Text PDFFront Psychol
April 2014
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam Amsterdam, Netherlands ; Neuroscience Campus Amsterdam Amsterdam, Netherlands.
The human brain frequently generates thoughts and feelings detached from environmental demands. Investigating the rich repertoire of these mind-wandering experiences is challenging, as it depends on introspection and mapping its content requires an unknown number of dimensions. We recently developed a retrospective self-report questionnaire-the Amsterdam Resting-State Questionnaire (ARSQ)-which quantifies mind wandering along seven dimensions: "Discontinuity of Mind," "Theory of Mind," "Self," "Planning," "Sleepiness," "Comfort," and "Somatic Awareness.
View Article and Find Full Text PDFFront Hum Neurosci
September 2013
1Retinal Signal Processing, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
In the vertebrate retina, cones project to the horizontal cells (HCs) and bipolar cells (BCs). The communication between cones and HCs uses both chemical and ephaptic mechanisms. Cones release glutamate in a Ca(2+)-dependent manner, while HCs feed back to cones via an ephaptic mechanism.
View Article and Find Full Text PDFFront Mol Neurosci
October 2012
Department of Synapse and Network Development, Netherlands Institute for Neuroscience Amsterdam, Netherlands.
To contribute to a functional network a neuron must make specific connections and integrate the synaptic inputs that it receives in a meaningful way. Previous modeling and experimental studies have predicted that this specificity could entail a subcellular organization whereby synapses that carry similar information are clustered together on local stretches of dendrite. Recent imaging studies have now, for the first time, demonstrated synaptic clustering during development and learning in different neuronal circuits.
View Article and Find Full Text PDFFront Neuroanat
July 2011
Netherlands Institute for Neuroscience Amsterdam, Netherlands.
According to His (1891, 1893) the brainstem consists of two longitudinal zones, the dorsal alar plate (sensory in nature) and the ventral basal plate (motor in nature). Johnston and Herrick indicated that both plates can be subdivided into separate somatic and visceral zones, distinguishing somatosensory and viscerosensory zones within the alar plate, and visceromotor and somatomotor zones within the basal plate. To test the validity of this "four-functional-zones" concept, I developed a topological procedure, surveying the spatial relationships of the various cell masses in the brainstem in a single figure.
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