36 results match your criteria: "Netaji Subhas Medical College[Affiliation]"

Background: Despite the increasing integration of competency-based education in medicine, there remains a significant gap in effectively assessing educational outcomes, underscoring the urgent need for designed assessment blueprints that accurately reflect both curriculum content and competency standards in Community Medicine for undergraduate students. This study, conducted across the All-India Institute of Medical Sciences (AIIMS) network, develops a summative assessment blueprint aimed at standardizing evaluations in medical education across diverse geographic locations in India.

Methods: Twenty-five experts from 10 All India Institutes of Medical Science were invited via email and contributed for summative assessment for a theory paper.

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Background:  Nontraumatic acute abdominal pain is a common presentation in emergency settings, often requiring surgical intervention. This study aimed to explore the clinical presentations, surgical management, and outcomes in patients with nontraumatic acute abdominal pain, providing insights for improving management strategies.

Methods: This observational study was conducted at a tertiary care hospital in North India and included 433 patients who underwent elective and emergency abdominal surgeries from June 2021 to May 2023.

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Introduction Semen quality, characterized by parameters such as sperm count, motility, and morphology, determines successful fertilization and subsequent embryo health. This study investigates the impact of sperm parameters on embryo quality in assisted reproductive technology (ART). Methods The study utilized a retrospective design with 194 male and 194 female participants who underwent fertility treatment from October 2020 to May 2024.

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  • * A total of 277 children participated, with the majority being male, and the most common reasons for biopsy included atypical ages and steroid resistance.
  • * The leading histopathological finding was focal segmental glomerulosclerosis (FSGS), indicating that renal biopsies are safe and effective in diagnosing and managing kidney disorders in pediatric patients.
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  • Pigment-induced acute kidney injury (AKI) occurs when harmful pigments from myoglobin or hemoglobin cause damage to the kidneys, often linked to conditions like rhabdomyolysis or hemolysis.
  • The study reports eight cases of pigment-induced AKI, primarily from myoglobin and hemoglobin casts, triggered by factors such as intense exercise, infections, or certain medications.
  • While most patients required dialysis initially, their short-term kidney recovery was positive, highlighting the need for ongoing monitoring to check for potential long-term effects.
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Background: Professionalism is a core quality which has to be developed and imbibed by medical students. However, training in professionalism was not a part of the medical curriculum until recently when the Competency-Based Medical Education system was introduced for undergraduate medical students in India, by the National Medical Commission. However, there has been no formal training on professionalism, in the curriculum of postgraduate (PG) medical students in India.

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Background The National Medical Commission (NMC), the regulatory body for medical education in India introduced competency-based medical education (CBME) in 2019. It is an outcome-based learner-centric approach. To implement it, active and innovative learning strategies are being introduced.

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Background Periodontitis has a vital role in eliciting a cross-reactivity or systemic inflammatory response, making periodontal inflamed surface area (PISA) a primary contributor to the inflammatory burden posed by periodontitis. PISA helps in the quantification of the amount of inflamed periodontal tissue. However, the existing literature data concerning PISA as an indicator of inflammatory burden are scarce, with limited research on the relationship between systemic inflammatory markers and PISA.

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Background Dental age estimation plays an enormous role in the determination of an individual's identity and age in forensic and anthropological fields. The estimation of the chronological age of the individual is also important in the diagnosis, treatment planning, and treatment outcomes in the dental field. The third molar has some inimitable characteristics in terms of its size, shape, formation, and long path of eruption and usually erupts after puberty, which seems to be a reliable method of age estimation in adulthood.

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  • Gestational hypertension poses risks for both mothers and babies, potentially leading to conditions like preeclampsia; this study investigates sympathetic nervous system function in affected women.
  • The study included 52 women with pregnancy-induced hypertension and 52 without, assessing their blood pressure responses to exercise to determine differences in autonomic function.
  • Results indicated significantly higher blood pressure responses in the hypertensive group, suggesting that the increased sympathetic activity is linked to a higher risk of developing preeclampsia or eclampsia, highlighting a potential area for new treatments.
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Background The research delves into the intricate relationship between periodontal health and specific blood biomarkers in pregnant women during their second trimester. It specifically focuses on the levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), and C-reactive protein (CRP) in those suffering from chronic periodontitis compared to healthy controls. Methodology A detailed approach was taken involving 60 pregnant women categorized into two groups based on the presence or absence of chronic periodontitis.

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Background: Adolescence is a transitional phase marked by the onset of menarche. Most adolescent girls have incomplete or inaccurate information about menstrual physiology and hygiene. There are several misconceptions and taboos linked with it, resulting in adverse health outcomes.

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Background: Chronic periodontitis is the most common dental disease reported globally as well as in India. Periodontal pathogens are usually seen in samples of gingival tissues, crevicular blood, GCF (gingival crevicular fluid), and dental plaque. Apart from the conventional mechanical treatment, laser disinfection is a recent advancement that change shows greater efficacy in reducing the disease progression and changing the bacterial flora.

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Introduction: Male infertility contributes to a significant proportion of infertility cases, and advanced paternal age has been suggested to affect semen quality and fertility. However, the relationship between age and semen quality remains inconclusive, with conflicting findings reported in the literature. This study aimed to investigate the effect of age on semen quality among male partners of infertile couples in a tertiary care center in eastern India.

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A hypnic jerk is an abrupt, involuntary, nonrepetitive contraction of muscles of the body that occurs during the onset of sleep in stage 1 of nonrapid eye movement sleep. Various physiological and stressful stimuli can precipitate hypnic jerks with no further neurological sequelae. Although selective serotonin reuptake inhibitor (SSRI) medications are well known to disturb the normal sleep cycle and cause rapid eye movement sleep behavioral disorders, there were only a few case reports of them causing hypnic jerks and those were reported due to Escitalopram only.

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  • Children with special healthcare needs in Jodhpur District, India, have a high prevalence of dental caries, with 65% affected, and varying severity classified as mild, moderate, or severe.
  • The study found that 75% of these children have poor oral hygiene, with a mean deft index score of 2.8, indicating a significant history of dental issues.
  • Many children reported insufficient oral hygiene practices; 60% brush once daily, 70% do not use fluoride, and 55% do not floss, suggesting a critical need for targeted oral health interventions and education.
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Therapeutic drug monitoring in India: A strength, weakness, opportunity and threats analysis.

Br J Clin Pharmacol

November 2023

Clinical Pharmacology, Indian Council of Medical Research, New Delhi, India.

Article Synopsis
  • Therapeutic Drug Monitoring (TDM) is becoming a crucial part of precision medicine, yet its implementation in India is limited mostly to a few academic centers despite its potential benefits.
  • Factors unique to India's population, such as nutritional deficiencies and alternative medicine use, create challenges for TDM application, highlighting the need for more targeted research and data.
  • A SWOT analysis aims to identify ways to enhance TDM's presence in India, advocating for a collaborative effort among professionals, clinicians, and government to develop a National Action Plan and establish dedicated TDM centers.
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Clinical Pharmacological Reconciliation, Review, and Feedback in Ensuring Patient Safety: A Commentary.

J Clin Pharmacol

September 2023

MBBS MD DM (Clinical Pharmacology), Consultant Clinical Pharmacologist, Academic Dean, Professor & Head, Department of Pharmacology, Netaji Subhas Medical College & Hospital, Patna, Bihar, India.

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  • Liquid biopsy testing for circulating tumor cells (CTCs) in women with suspected ovarian cancer shows potential in predicting chemoresistance and survival outcomes.
  • A study found CTCs in 25.7% of women with malignancies, indicating a strong correlation between CTC presence and advanced cancer stages.
  • The detection of EpCAM+ CTCs at diagnosis independently predicts lower chances of survival and resistance to chemotherapy, suggesting the need for targeted anti-EpCAM therapies.
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Background: Cough is a wearisome and exasperating symptom affecting the daily life of the infected patient. Cough due to coronavirus disease 2019 (COVID-19) causes excessive morbidity in human populations globally. Apart from the morbidity associated with cough, it also enhances the transmission of this viral infection through droplets.

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  • The study investigates the association between specific single-nucleotide polymorphisms (SNPs), MTHFR C677T and MTR A2756G, and their potential role in neural tube defects (NTDs) during pregnancy, emphasizing the importance of folate levels.
  • It involved 397 participants (163 with NTDs and 234 controls), examining their genetic profiles and measuring red blood cell (RBC) folate levels using specific laboratory techniques.
  • The findings revealed lower RBC folate levels in NTD patients compared to controls and suggest that certain genetic variants in MTHFR and MTR are linked to an increased risk of NTDs during pregnancy
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Aim: This systematic review and meta-analysis was conducted to evaluate the efficacy and safety of lobeglitazone as compared to the standard of care (SOC) in patients with type 2 diabetes mellitus (T2DM).

Methods: Databases were searched for relevant randomized controlled trials. The primary outcome was the comparison of the glycated hemoglobin (HbA1C) level after 24 weeks.

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