Comparing Thulium Fiber Versus High-Power Holmium Laser Lithotripsy Combined with the Flexible and Navigable Suction Access Sheath in Flexible Ureteroscopy for Kidney Stone Disease: A Propensity Score Matched Analysis by the Global FANS Collaborative Group.

We aim to evaluate stone-free rate (SFR) and complications after flexible ureteroscopy (F-URS) for kidney stones, using a flexible and navigable suction ureteral access sheath (FANS), comparing thulium fiber laser (TFL) and high-power holmium:yttrium-aluminum-garnet laser (HPHL). Data from adults who underwent F-URS in 15 centers were prospectively analyzed (August 2023-January 2024). Exclusion criteria were ureteral stones, concomitant bilateral procedures, and renal abnormalities.

Thulium fiber laser versus pulsed Thulium:YAG for laser lithotripsy during flexible ureteroscopy.

To compare the pulsed-Thulium: YAG(p-Tm: YAG) and Thulium Fiber(TFL) lasers in terms of efficiency and safety profiles during flexible ureteroscopy(fURS) and endocorporeal laser lithotripsy(ELL). A prospective single-center open-label comparative study included consecutive patients with ureteral and renal stones who underwent fURS using Thulio(p-Tm: YAG, Dornier©,Germany) or TFL Drive(TFL, Coloplast©,Danemark), with 270 μm and 150/200μm laser fibers(LF), respectively. fURS were performed by a single operator in each group.

Robotic-assisted laparoscopic pyelolithotomy in a horseshoe kidney.

Nephrolithiasis is one of the most common indications for surgery in patients with a horseshoe kidney. Robotic-assisted surgery has become a staple in urologic practice, yet its application in stone management is largely undefined. We present a patient with a horseshoe kidney, who underwent a robotic-assisted laparoscopic pyelolithotomy (RPL) to treat a 3 cm stone burden.

Which is a Better Predictor for the Safety and Efficacy of Retrograde Intrarenal Surgery; Stone Size or Volume? A Study of RIRsearch Study Group.

To compare the predictive effects of stone size and volume on the efficacy and safety of retrograde intrarenal surgery (RIRS) and to determine the cutoff values of stone volume for prediction of RIRS efficacy and safety. Patients who underwent RIRS between 2017 and 2021 in six referral centers were retrospectively included in the study. The database of the RIRsearch group, which was formed prospectively, was used for this retrospective analysis.

Intraosseous Hemangioma of the Iliac Bone: An Incidental Finding Mimicking Metastatic Disease.

Intraosseous hemangiomas are rare benign vascular tumors predominantly occurring in the axial skeleton. This case report describes a 44-year-old female with a history of multiple renal stones and benign breast calcifications, who was incidentally found to have a 1.2 cm lucent lesion in the left iliac bone during imaging for nephrolithiasis.

Risk of Nephrolithiasis Associated With SGLT2 Inhibitors Versus DPP4 Inhibitors Among Patients With Type 2 Diabetes: A Target Trial Emulation Study.

Objective: We aim to compare the risk of nephrolithiasis among type 2 diabetes patients who initiated sodium-glucose cotransporter 2 inhibitors (SGLT2is) versus dipeptidyl peptidase 4 inhibitors (DPP4is), individually within stone never- and ever-formers.

Research Design And Methods: Using the 2010-2021 Korea National Health Insurance Service database, we conducted a population-based cohort study, comparing initiators of SGLT2is versus DPP4is. The primary outcome was incident nephrolithiasis.

Annexin-derived self-assembling peptide nanostructures for alleviation of calcium oxalate -induced renal injury.

The formation of polycrystalline aggregates in the glomerulus or other components of the urinary system is indisputably the most critical step in the formation of kidney stones and calcium oxalate monohydrate (CaCO·HO) is the most prevalent form. On the other hand, Annexin A1 (ANXA1), a calcium-binding protein, markedly increased on the apical surface of renal cells in CaCO-induced nephrolithiasis. In this regard, we identified the peptide motif responsible for calcium binding and redesigned it into a self-assembling peptide sequence without disturbing its binding selectivity for the CaCO interface.

A mouse model for the study of diet-induced changes in intestinal microbiome composition on renal calcium oxalate crystal formation.

Currently available animal models for calcium oxalate kidney stones are limited in their translational potential. Particularly with increasing interest in gut microbiota involvement in kidney stone disease, there are limited animal models which can be used. As such, we have developed a novel diet-induced hyperoxaluria murine model which addresses some of the shortcomings of other currently available models.

Based on network pharmacology, the mechanism of Dioscin in alleviating renal tubular epithelial cell injury induced by calcium oxalate crystals was explored.

The commencement of kidney stone formation involves a crucial initial phase characterized by injury to renal tubular cells caused by calcium oxalate (CaOx). Dioscin (Dio) has been acknowledged for its potent anti-inflammation and anti-apoptotic properties; nevertheless, the impact and underlying Investigation into the molecular basis underlying the action of Dioscin in mitigating inflammation and apoptotic induced by exposure to calcium oxalate crystals in renal tissues remain unexplored. To comprehend the precise mechanism of Dioscin in the treatment of crystalline nephropathy, we conducted experiments utilizing a murine model of CaOx crystal deposition, induced by intraperitoneal administration of glyoxylate.

Mechanism of Nephrolithiasis: Does the Microbiome Play a Role?

Nephrolithiasis imposes a significant health care burden around the world. In the past decade, there has been considerable interest in the human microbiota in relation to the onset of nephrolithiasis. Most of the research has focused on degradation of oxalate, a known causative factor for nephrolithiasis, by bacteria in the gut.

Renal Infarction in a Newly Diagnosed Atrial Fibrillation Patient.

Renal infarction is a rare but potentially serious condition, often misdiagnosed due to its non-specific presentation, which mimics conditions such as nephrolithiasis and pyelonephritis. Discussed in this case report is a 68-year-old woman who presented to an emergency department with two weeks of worsening left flank pain. She was found to have a new diagnosis of atrial fibrillation (AF) on electrocardiogram (ECG) and CT findings revealing renal infarction.

Development and Implementation of an Evidence-Based Electronic Request Bundle for Metabolic Screening in Patients With Urinary Tract Calculi.

Introduction Kidney stone disease is a global health issue, with a well-known high recurrence rate after a first stone episode. Metabolic screening is a cost-effective tool for identifying patients at risk of recurrence due to a secondary disease. Our study aimed to assess compliance in a District General Hospital (DGH) and lay out a framework for the implementation of an electronic request bundle to improve screening levels in line with National Institute for Health and Care Excellence (NICE) guidelines.

Cefazolin shifts the kidney microbiota to promote a lithogenic environment.

Clinical studies of the urinary tract microbiome, termed urobiome, suggest a direct, antibiotic-dependent, impact of the urobiome on kidney physiology. However, evidence for kidney bacteria comes from indirect sources or infected tissue. Further, it is unclear how antibiotics impact kidney bacteria.

Assessing Changes in Nonspecific Symptoms After Parathyroidectomy for Primary Hyperparathyroidism Using a Smartwatch.

Objective: Parathyroidectomy (PTX) is indicated in primary hyperparathyroidism (PHPT) with osteoporosis or nephrolithiasis. There is not a uniform consensus on the benefit of PTX for nonspecific symptoms, but patient-reported questionnaires have demonstrated improved quality of life (QOL) afterward. This study aimed to evaluate physical activity and sleep after PTX using smartwatch technology.

Therapeutic targets of antidiabetic drugs and kidney stones: A druggable mendelian randomization study and experimental study in rats.

Diabetes is known to increase the risk of kidney stones, but the influence of antidiabetic drugs on this risk remains uncertain. Genetic instruments for antidiabetic drugs were identified as variants, which were associated with both the expression of genes encoding target proteins of drugs and glycated hemoglobin level (HbA1c). Here, we investigated the effect of antidiabetic drugs on kidney stones in a mendelian randomization (MR) framework, and further explore the potential effect on CaOx stone rat models induced by glyoxylic acid.

Luteolin alleviated calcium oxalate crystal induced kidney injury by inhibiting Nr4a1-mediated ferroptosis.

Background: The global incidence of calcium oxalate (CaOx) kidney stones is rising, and effective treatments remain limited. Luteolin (Lut), a naturally flavonoid present in several plants, is recognized for its anti-inflammatory, anti-injury, and neuroprotective effects. However, its effects on CaOx kidney stone formation and the associated kidney damage are still unknown.

Special Considerations in the Treatment of Idiopathic Intracranial Hypertension.

Purpose Of Review: To review the management of Idiopathic Intracranial Hypertension (IIH) with co-existing conditions affecting therapy: obesity, sulfa allergy, nephrolithiasis, and pregnancy.

Recent Findings: The IIH-WT trial showed that bariatric surgery is currently the most effective method for obese patients with IIH to lose weight, leading to normalization of CSF pressure in many cases. Allergy to sulfonamide antibiotics does not preclude the use of acetazolamide; rather, penicillin allergy or multiple drug allergies are the strongest predictor of a hypersensitivity reaction.

Mini-endoscopic combined intrarenal surgery (mini-ECIRS) for complex urolithiasis.

Introduction: To miniaturize endourological procedures, mini-Endoscopic Combined Intrarenal Surgery (mini-ECIRS) has emerged as a promising alternative in the treatment of complex kidney and ureteral stones. To date, some data available in the literature have shown good outcomes regarding effectiveness and safety. This study aimed to evaluate the results and postoperative complications of mini-ECIRS in our series.

Kidney stone analysis: an EAU section of urolithiasis (EULIS) survey on current practices and perspectives worldwide.

Purpose: To investigate the current thoughts and perspectives on kidney stone analysis amongst urologists and urology residents worldwide.

Methods: In October 2022 an online survey supported by the EULIS was circulated amongst urologists and urology residents worldwide. The survey was based on the current EAU guidelines regarding stone analysis and its role in urolithiasis management.

Identifying and Evaluating Online Kidney Stone Pain Resources: A Cross-Sectional Study.

Introduction and objectives With the continuous growth of social media platforms, an increasing number of individuals are turning to them as their main source of medical information. This article aims to pinpoint the most widely accessed online resources on kidney stone pain among those who suffer from kidney stones and to assess the reliability, understandability, quality, and actionability of their content. Materials and methods The social media analysis platform BuzzSumo was employed to identify pertinent articles and assess their engagement levels.

Unique Pathological Findings of Polarized Calcium Oxalate Crystals in Spondylodiscitis of an ESRD Hemodialysis Patient: A Case Report.

Patients with end-stage renal disease (ESRD) undergoing chronic hemodialysis are at an increased risk of developing spondylodiscitis, an infectious condition affecting the vertebral column. In this case report, we present a 22-year-old male with ESRD, a history of hyperoxaluria, nephrolithiasis, and anemia, who developed spondylodiscitis. Notably, pathological examination of tissue samples obtained during surgical intervention revealed the presence of polarized calcium oxalate crystals within the lumbar laminae and spinal discs, a rare finding in this clinical context.

Predictive Factors for Major Bleeding in Patients Undergoing Percutaneous Nephrolithotomy: A Clinical Prediction Study.

Objective: To evaluate major bleeding risk factors in percutaneous nephrolithotomy (PCNL) for upper urinary tract calculi and validate a prediction model.

Study Design: Analytical study. Place and Duration of the Study: The First Affiliated Hospital of Wannan Medical College, Wuhu, China, from January 2019 to August 2023.

[Clinical features and the process of renal stone formation in elderly patients with calculous pyelonephritis].

Aim: Calculous pyelonephritis is a severe infectious disease that predominantly affects the elderly population. However, there are few detailed reports on the stone formation process in calculous pyelonephritis. The purpose of this study was to investigate the process of calculous pyelonephritis formation and to identify markers of its onset.