859 results match your criteria: "Neonatal Lupus Erythematosus"

Objective: To study the clinical features and laboratory parameters of neonatal lupus erythematosus (NLE) from India.

Patients And Methods: We analyzed case records of children diagnosed with NLE in the Pediatric Rheumatology Clinic at tertiary care centre from North India during the period January 1999 - December 2023.

Results: Twenty-four babies are diagnosed with NLE during the study period.

View Article and Find Full Text PDF

Introduction: There are few reports of severe hematological involvement in children with neonatal lupus erythematosus (NLE) treated with exchange transfusion. In this case report, we present a female patient with NLE admitted to the Children's Hospital of Soochow University. The main clinical manifestations were pancytopenia and congenital heart block (CHB).

View Article and Find Full Text PDF

Fetal-hope study: Home monitoring of fetal heart rate in SSA + pregnant women: Rationale and design.

Eur J Obstet Gynecol Reprod Biol

December 2024

Department of Internal Medicine, ASST Fatebenefratelli-Sacco, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Italy.

Article Synopsis
  • About 0.5-1% of women of childbearing age have anti-Ro/SSA and anti-La/SSB antibodies, potentially leading to Neonatal Lupus, primarily manifesting as complete heart block (AVB) in fetuses.
  • The study aims to assess the effectiveness of home monitoring of fetal heart rates using a handheld device in pregnant women with these antibodies and to see if early treatment can help.
  • Currently, patients are being recruited across 11 Italian centers for a prospective observational study, with regular monitoring and check-ups to track maternal and fetal health outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • Feto-maternal microchimerism refers to the exchange of cells between a mother and her fetus during pregnancy, impacting health for both parties even into later life.
  • The effects of these transferred cells can be harmful for the mother—linked to complications like pre-eclampsia and autoimmune diseases—but may also have beneficial roles in tissue healing and disease recovery.
  • Research is limited on how maternal microchimeric cells could contribute to autoimmune conditions in the child, particularly conditions like Type 1 diabetes and neonatal lupus, where these cells might either harm or assist in the immune response.
View Article and Find Full Text PDF

Response to Kan et al., "A case of neonatal lupus erythematosus presenting with extensive erosions at birth, healing with extensive scarring".

JAAD Case Rep

October 2024

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Skin and Immune Diseases, Beijing, China.

View Article and Find Full Text PDF

A review of neonatal lupus syndrome.

Sci Prog

September 2024

Internal Medicine/Rheumatology, Virginia Tech Carilion School of Medicine (VTCSOM), Roanoke, VA, USA.

Article Synopsis
  • Neonatal lupus syndrome (NLS) is a condition that can affect babies when their moms pass certain antibodies to them during pregnancy.
  • These maternal antibodies can sometimes help protect the baby, but they can also cause problems like skin rashes or serious heart issues.
  • To help prevent NLS, doctors suggest screening moms-to-be for these antibodies, especially if they have family members or conditions related to autoimmune diseases.
View Article and Find Full Text PDF
Article Synopsis
  • * A case report details a baby with NLE and MAS showing symptoms such as fever, convulsions, and rash, highlighting the seriousness of the condition.
  • * High-dose gamma globulin and steroids are recommended as initial treatments, and monitoring the rash is suggested to assess treatment effectiveness.
View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on neonatal systemic lupus erythematosus (NLE), an autoimmune disease in newborns, specifically examining cases where patients also had rare effusions like pleural or pericardial effusion.
  • Researchers collected and analyzed clinical data from 2011 to 2023, categorizing patients into two groups: those with effusions and those without, to compare their clinical characteristics.
  • Findings revealed that 24.44% of NLE patients experienced effusions, with significant differences in various lab results between groups, indicating a more severe clinical presentation in those with effusions, but all effusions eventually resolved on their own.
View Article and Find Full Text PDF

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominantly affects women of childbearing age. Pregnancy in SLE patients poses unique challenges due to the potential impact on maternal and fetal outcomes. We provide an overview of the management of SLE during pregnancy, including preconception risk stratification and counseling, treatment, and disease activity monitoring.

View Article and Find Full Text PDF

Objectives: To present a rare case of neonatal lupus erythematosus (NLE) associated with suspected hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS).

Case Presentation: A female infant weighing 2,995 g was born to a mother without medical history of any disease. At birth, the patient had erythematous papules on her face and trunk.

View Article and Find Full Text PDF

We present the case of a 27-year-old pregnant woman, newly diagnosed with Systemic Lupus Erythematosus (SLE) during pregnancy. The patient delivered a newborn at 38 weeks gestation, who, on the first day of life, manifested complete heart block. This case underscores the clinical challenges associated with neonatal lupus, emphasizing the need for collaborative, multidisciplinary management.

View Article and Find Full Text PDF

Genetics of Neonatal Lupus Erythematosus Risk and Specific Manifestations.

J Rheumatol

July 2024

L.T. Hiraki, MD, ScD, Genetics & Genome Biology, Research Institute, and Division of Rheumatology, The Hospital for Sick Children, and Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: Neonatal lupus erythematosus (NLE) is a passively acquired autoimmune disease in infants born to anti-Ro and/or anti-La autoantibody-positive mothers. Genetics may affect NLE risk. We analyzed the genetics of infants and anti-Ro antibody-positive mothers, with NLE and NLE-specific manifestations.

View Article and Find Full Text PDF

This study, conducted by searching keywords such as "maternal lupus", "neonatal lupus", and "congenital heart block" in databases including PubMed and Scopus, provides a detailed narrative review on fetal and neonatal lupus. Autoantibodies like anti-Ro/SSA and anti-La/SSB may cross the placenta and cause complications in neonates, such as congenital heart block (CHB). Management options involve hydroxychloroquine, which is able to counteract some of the adverse events, although the drug needs to be used carefully because of its impact on the QTc interval.

View Article and Find Full Text PDF

Background: Neonatal lupus (NL) is extremely rare and is caused by the transplacental passage of maternal IgG autoantibodies against Ro, La, and/or RNP proteins into the fetal circulation, which can cause congenital complete atrioventricular block (CCAB), permanent skin lesions, and liver involvement.

Objective: To know the prevalence of NL in patients with CCAB and the clinical course in long-term follow-up.

Methods: From January 1992 to December 2017, patients with CCAB were included.

View Article and Find Full Text PDF
Article Synopsis
  • Neonatal lupus erythematosus (NLE) is a rare autoimmune disease that can cause liver damage in newborns, sometimes in association with cytomegalovirus (CMV) colonization.!* -
  • A case study of a newborn revealed sustained liver function damage linked to NLE, identified through various diagnostic methods including lab tests and family history.!* -
  • The study emphasizes the importance of quickly investigating liver issues in newborns to determine if NLE is the underlying cause, given its potential to cause significant organ dysfunction.!*
View Article and Find Full Text PDF

Issues with pregnancy in systemic lupus.

Joint Bone Spine

December 2024

Service de médecine interne, Centre de références maladies auto-immunes et systémiques rares d'Île-de-France, Cochin, AP-HP, Paris, France; Université Paris Cité, Paris, France; Centre de recherche en épidémiologie et statistiques, université Paris Cité (CRESS), équipe Épidémiologie clinique appliquée aux maladies rhumatismales et musculosquelettiques (ECAMO), Inserm U1153, Paris, France.

Article Synopsis
  • Systemic lupus erythematosus is a disease that mainly affects young women, but pregnancies can be safe if the disease is managed well.
  • Pregnancy poses more risks for these women compared to others, so careful planning and good advice before getting pregnant are really important.
  • Doctors need to keep an eye on certain health factors that could lead to complications during pregnancy, and some treatments can safely continue to help manage lupus.
View Article and Find Full Text PDF

Rationale: Neonatal septic meningitis is a serious condition that can be caused by various pathogens, including Corynebacterium aurimucosum, a rare and opportunistic bacterium. We reports a case of infectious meningitis in a premature infant with neonatal lupus erythematosus caused by C aurimucosum. The purpose of this study is to explore the occurrence of meningitis caused by C aurimucosum in preterm infants with neonatal lupus erythematosus.

View Article and Find Full Text PDF
Article Synopsis
  • - This study looked at how newborns with neonatal lupus erythematosus (NLE) can also have tummy problems, like trouble eating and diarrhea, which hasn't been studied much before.
  • - Out of 39 NLE patients, 27 had gastrointestinal issues and some tested positive for specific harmful antibodies that can cause these problems.
  • - The mothers of affected newborns often had autoimmune diseases, and the research suggests doctors should be careful when looking for NLE, especially if the baby has a rash or other issues.
View Article and Find Full Text PDF

[Research progress on the manifestations and prognosis of neonatal lupus erythematosus in various systems].

Zhongguo Dang Dai Er Ke Za Zhi

January 2024

Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China (Zhang X-R, Email: icy.zhang@ 163. com).

Neonatal lupus erythematosus (NLE) is caused by the transmission of maternal anti-Ro/SSA antibodies, anti-La/SSB antibodies, and other autoantibodies to the fetus through the placenta. Usually, with the disappearance of autoantibodies in the children's body, abnormal changes in the mucocutaneous, blood system, and digestive system can spontaneously subside, but the damage to various systems caused by autoantibodies may persist for a long time. This article provides a comprehensive review of the manifestations and prognosis of NLE in various systems, including mucocutaneous, blood system, circulatory system, nervous system, digestive system, respiratory system, aiming to provide reference for clinical work.

View Article and Find Full Text PDF

Introduction: Neonatal lupus erythematosus (NLE) is a rare autoimmune disease, which needs to be distinguished from eczema, congenital syphilis, and tinea corporis in newborns. Reflectance confocal microscopy (RCM) could be a helpful noninvasive diagnostic tool, which has been used to evaluate several inflammatory skin conditions. The aim of this study was to describe the RCM characteristics of NLE.

View Article and Find Full Text PDF