The importance of nutritional factors and dietary management of Hashimoto's thyroiditis.

Hashimoto (HT) is an autoimmune disease in which destruction of the thyroid occurs as a result of lymphocyte infiltration. It is caused by an increased level of titers of antibody against thyroid peroxidase (TPO) and thyroglobulin (TG). Because of that,in HT patients, changes are observed in the level and metabolism of thyroid hormones, which leads to unspecified physical and psychological symptoms.

Dendrites as separate compartment - local protein synthesis.

The article summarizes the most meaningful studies which have provided evidence that protein synthesis in neurons can occur not only in cell perikarya but also locally in dendrites. The presence of the complete machinery required to synthesize cytoplasmic and integral membrane proteins in dendrites, identification of binding proteins known to mediate mRNA trafficking in dendrites and the ability to trigger "on-site" translation make it possible for the synthesis of particular proteins to be regulated by synaptic signals. Until now over 100 different mRNAs coding the proteins involved in neurotransmission and modulation of synaptic activity have been identified in dendrites.