1,118 results match your criteria: "Nemours Children's Hospital.[Affiliation]"
Am J Hum Genet
March 2024
Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:
Pathogenic variants in multiple genes on the X chromosome have been implicated in syndromic and non-syndromic intellectual disability disorders. ZFX on Xp22.11 encodes a transcription factor that has been linked to diverse processes including oncogenesis and development, but germline variants have not been characterized in association with disease.
View Article and Find Full Text PDFJAMA Surg
May 2024
Nemours Children's Hospital Delaware, Wilmington, Delaware.
Pediatrics
March 2024
Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.
The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, some experience longer lasting effects. Data regarding the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) in children, or long COVID, are only just emerging in the literature.
View Article and Find Full Text PDFJ Am Coll Radiol
March 2024
Center for Pediatric and Maternal Value, Stanford Medicine Children's Health, Palo Alto, California; Department of Pediatrics, Baylor College of Medicine, Houston, Texas; Chief Safety Officer, Deputy Chief Quality Officer, Texas Children's Hospital.
Clin Pract
December 2023
Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Autosomal recessive polycystic kidney disease (ARPKD) is often associated with hepatobiliary disease in the form of hepatic fibrosis and/or Caroli disease. Combined liver-kidney transplantation (CLKT) is a transplant modality of choice in children with both end-stage renal disease (ESRD) and severe hepatic disease. However, there is no consensus on whether children with ARPKD-associated ESRD without severe hepatic disease can be treated with isolated kidney transplantation (KT) without the need for CLKT.
View Article and Find Full Text PDFUrol Case Rep
March 2024
University of Central Florida College of Medicine, 6850 Lake Nona Blvd, Orlando, FL, 32827, USA.
The urachus is an embryologic remnant that connects the bladder to the umbilicus and typically obliterates during gestation. Urachal cysts are one of the most common congenital urachal anomalies. Urachal cysts may be found incidentally on imaging or present as a palpable mass with abdominal pain and fever.
View Article and Find Full Text PDFClin Pediatr (Phila)
November 2024
Diagnostic Referral Service, Nemours Children's Hospital, Wilmington, DE, USA.
We conducted a retrospective chart review of patients with neuromuscular scoliosis following spinal fusion surgery who were cared for post-operatively by either a hospitalist/orthopedics co-management team or a complex care clinic (CCC). Assignment to either treatment group was not random. To account for baseline differences between groups, we calculated propensity scores and used these as probability weights in generalized linear models.
View Article and Find Full Text PDFRestrictive abortion laws have impacts reaching far beyond the immediate sphere of reproductive health, with cascading effects on clinical and ethical aspects of neonatal care, as well as perinatal palliative care. These laws have the potential to alter how families and clinicians navigate prenatal and postnatal medical decisions after a complex fetal diagnosis is made. We present a hypothetical case to explore the nexus of abortion care and perinatal care of fetuses and infants with life-limiting conditions.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
May 2024
From the University of Central Florida College of Medicine, Orlando, FL (Garner and Ibanez), Department of Orthopedics, Nemours Children's Hospital Florida, Orlando, FL (Erkilinc, Espina-Rey, Ilgenfritz, Lovejoy, and Malone).
Background: Implants are routinely removed in pediatric patients. Fracture through the prior implant site is a common worry after implant removal. Early post-implant removal radiographs are routinely used to evaluate the prior implant removal sites and to assess when a patient may return to normal activities.
View Article and Find Full Text PDFPediatr Rep
January 2024
Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Pediatr Cardiol
January 2024
Nemours Cardiac Center, Nemours Children's Hospital Delaware, 1600 Rockland Rd, Wilmington, DE, 19803, USA.
Becker muscular dystrophy (BMD) is an X-linked recessive disorder responsible for mild skeletal muscle involvement and variable degree of cardiomyopathy. The characteristics of cardiac phenotype of BMD in childhood remain elusive. Clinical manifestations, genotype, serum biomarkers, and echocardiogram were retrospectively reviewed in BMD patients.
View Article and Find Full Text PDFPediatrics
January 2024
Division of Emergency Medicine, University Department of Pediatrics, Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington.
Objectives: To identify independent predictors of and derive a risk score for acute hematogenous osteomyelitis (AHO) in children.
Methods: We conducted a retrospective matched case-control study of children >90 days to <18 years of age undergoing evaluation for a suspected musculoskeletal (MSK) infection from 2017 to 2019 at 23 pediatric emergency departments (EDs) affiliated with the Pediatric Emergency Medicine Collaborative Research Committee. Cases were identified by diagnosis codes and confirmed by chart review to meet accepted diagnostic criteria for AHO.
Crit Care Explor
January 2024
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Objectives: Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this risk varied across biomarker-based risk strata upon adjusting for illness severity, presence of severe acute kidney injury (acute kidney injury), and use of continuous renal replacement therapy (CRRT) in pediatric septic shock.
Design: Ongoing multicenter prospective observational cohort.
J Pediatr
April 2024
Section of Pediatric Emergency Medicine, Departments of Pediatrics and Emergency Medicine, Yale School of Medicine, New Haven, CT.
In this multicenter, cross-sectional, secondary analysis of 4042 low-risk febrile infants, nearly 10% had a contaminated culture obtained during their evaluation (4.9% of blood cultures, 5.0% of urine cultures, and 1.
View Article and Find Full Text PDFCancer Res Commun
January 2024
Nemours Children's Hospital, Nemours Parkway, Orlando, Florida.
Unlabelled: Neuroblastoma is the most common extracranial tumor, accounting for 15% of all childhood cancer-related deaths. The long-term survival of patients with high-risk tumors is less than 40%, and MYCN amplification is one of the most common indicators of poor outcomes. Zika virus (ZIKV) is a mosquito-borne flavivirus associated with mild constitutional symptoms outside the fetal period.
View Article and Find Full Text PDFJ Neuromuscul Dis
March 2024
Nationwide Children's Hospital, Columbus, OH, USA.
Curr Opin Pediatr
February 2024
Nemours Children's Hospital Delaware, Wilmington, Delaware.
Pediatr Cardiol
January 2025
Department of Pediatrics, The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, Toronto, ON, Canada.
Kawasaki disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 show clinical overlap and both lack definitive diagnostic testing, making differentiation challenging. We sought to determine how cardiac biomarkers might differentiate KD from MIS-C. The International Kawasaki Disease Registry enrolled contemporaneous KD and MIS-C pediatric patients from 42 sites from January 2020 through June 2022.
View Article and Find Full Text PDFNeuromuscul Disord
January 2024
Folkhälsan Research Center, 00290 Helsinki, Finland; Department of Medical and Clinical Genetics, Medicum, 00014 University of Helsinki, Finland.
We describe three patients with asymmetric congenital myopathy without definite nemaline bodies and one patient with severe nemaline myopathy. In all four patients, the phenotype had been caused by pathogenic missense variants in ACTA1 leading to the same amino acid change, p.(Gly247Arg).
View Article and Find Full Text PDFJ Clin Immunol
December 2023
Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.
Zeta-chain associated protein kinase 70 kDa (ZAP70) combined immunodeficiency (CID) is an autosomal recessive severe immunodeficiency that is characterized by abnormal T-cell receptor signaling. Children with the disorder typically present during the first year of life with diarrhea, failure to thrive, and recurrent bacterial, viral, or opportunistic infections. To date, the only potential cure is hematopoietic stem cell transplant (HSCT).
View Article and Find Full Text PDFHosp Pediatr
January 2024
Stanford University School of Medicine, Palo Alto, California.
Background And Objectives: Eating disorders (EDs) affect a substantial number of American adolescents, with an increasing number seeking care for EDs during the coronavirus disease 2019 pandemic. We assessed the prevalence and clinical characteristics of adolescents hospitalized with EDs during 2010 to 2022.
Methods: We used data from a national database of 12 children's hospitals (PEDSnet).
J Pediatr Hematol Oncol
March 2024
Department of Pathology Division of Pediatric Hematology/Oncology, Nemours Center for Cancer and Blood Disorders, Nemours Children's Hospital-Delaware, Wilmington, DE.
Systemic Epstein-Barr virus-positive T-cell lymphoma of childhood (S-EBV-TCL) is a rare disease for which there is no standard of care. S-EBV-TCL is often associated with hemophagocytic lymphohistiocytosis and is generally thought of on the spectrum of EBV-related disease. For the few reported cases of cure in the literature, hematopoietic stem cell transplant has been required because it is the only treatment that has induced complete remission in patients suffering from EBV-associated T-cell or natural killer cell lymphoproliferative diseases, except hemophagocytic lymphohistiocytosis.
View Article and Find Full Text PDFCureus
November 2023
Inpatient Pediatrics, Nemours Children's Hospital, Orlando, USA.
Chilaiditi sign is defined as the interposition of the colon or small intestine between the liver and the right diaphragm in the absence of symptoms. Chilaiditi syndrome refers to the condition where the Chilaiditi sign is associated with symptoms including abdominal pain. In this series, we present the cases of two pre-pubescent patients with these rare conditions.
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