80 results match your criteria: "Nemours Children's Hospital-Delaware[Affiliation]"

Article Synopsis
  • The study aimed to analyze how changes in upper lumbar lordosis after spinal fusion affect the alignment of unfused lower lumbar segments in patients with Adolescent Idiopathic Scoliosis.
  • A retrospective review was conducted on 158 patients who underwent posterior spinal fusion, focusing on various spinal measurements and using MATLAB for 3D calculations.
  • Results indicated that increased upper lumbar lordosis influenced the lordotic shape of distal unfused segments, with varying impacts based on the specific levels of fusion, while overall sagittal alignment remained stable.
View Article and Find Full Text PDF
Article Synopsis
  • * A study using data from Maine found that only 23% of 799 children with complex CHD had received developmental or psychosocial encounters, with the majority occurring in community clinics or state programs rather than surgical centers.
  • * The findings suggest that CHD treatment centers should collaborate with external service providers to improve access and support for neurodevelopmental outcomes in these children.
View Article and Find Full Text PDF

Purpose Of Review: This scoping review aimed to identify implementation science (IS) research in pediatric diabetes, report integration of IS theory and terminology, and offer guidance for future research.

Recent Findings: Of 23 papers identified, 19 were published since 2017 and 21 focused on type 1 diabetes. Most involved medical evidence-based practices (EBPs; n = 15), whereas fewer focused on psychosocial (n = 7) and diabetes education (n = 2).

View Article and Find Full Text PDF

High-functioning palliative care teams are essential to high-quality care for individuals with serious illness and their families. Such teams are flexible and adapt to change. However, recent high turnover and understaffing, compounded by a pandemic, challenge even the most resilient and adaptable teams.

View Article and Find Full Text PDF
Article Synopsis
  • Research highlights a critical gap in understanding long COVID (PASC) in children and emphasizes the need for studies that define its characteristics in this age group.
  • The objective is to identify common prolonged symptoms in children aged 6 to 17 post-SARS-CoV-2 infection, examining differences between school-age kids and adolescents, as well as potential symptom clusters for future research.
  • A multicenter study involved nearly 5,000 participants, revealing that certain symptoms were significantly more prevalent in those with a history of COVID-19 compared to those without.
View Article and Find Full Text PDF

Objective: Hydrocephalus is a lifelong condition punctuated in most cases by unpredictable hospital admissions for surgical maintenance. It occupies more of the attention of the pediatric neurosurgeon than any other condition. Benchmarks for the measurement of outcomes are of interest to patients, their families, and the healthcare system.

View Article and Find Full Text PDF

The COVID-19 pandemic necessitated the closure of traditional simulation centers, prompting innovative solutions for medical education. Drawing from prior studies, which advocated for telesimulation and virtual reality (VR) as alternatives, this article explores the development and implementation of VR simulation in medical training. Leveraging the Acadicus VR platform, a VR simulation solution was created, enabling interactive scenarios simulating pediatric critical care situations.

View Article and Find Full Text PDF

Objective: Cerebral revascularization surgery (CRS) has been used to prevent stroke in children with sickle cell disease (SCD) and cerebral vasculopathy (e.g., moyamoya syndrome).

View Article and Find Full Text PDF

Background: Optimization of pulmonary to systemic blood flow (Qp: Qs) is the key to postoperative care of children with a single-ventricular heart. The ratio of end-tidal CO2 to partial pressure of CO2 called alveolar functional fraction (AFF) has shown a strong relationship with Qp: Qs in the catheterization lab in this population (with Qp: Qs of 1 correlating with AFF of 0.7).

View Article and Find Full Text PDF

Introduction: Although 200 000 adolescents undergo anterior cruciate ligament reconstruction (ACLR) surgery annually, no benchmarks for pediatric post-ACLR pain management exist. We created a multicenter, prospective, observational registry to describe pain practices, pain, and functional recovery after pediatric ACLR.

Methods: Participants (n=519; 12-17.

View Article and Find Full Text PDF

Objective: Accurate triage of minor head injuries remains a challenge for mature trauma systems. More than one-third of trauma transfers are overtriaged, and minor head injuries predominate. Overtriage is inefficient, wasteful of resources, and burdensome for families.

View Article and Find Full Text PDF
Article Synopsis
  • Collagen VI-related dystrophies (COL6-RDs) include a range of conditions such as Ullrich congenital muscular dystrophy (UCMD), which features severe muscle weakness and respiratory issues, and Bethlem muscular dystrophy, which has milder and later-presenting symptoms.
  • Some patients with symptoms typical of COL6-RDs were previously undiagnosed until a deep intronic variant in COL6A1 was identified, leading to a severe form of UCMD in a cohort of 44 patients, except for one with a milder phenotype.
  • The study suggests that a new pseudoexon skipping therapy could effectively reduce the severity of UCMD symptoms by targeting the abnormal transcripts
View Article and Find Full Text PDF

The role of an abbreviated ultrasound in the evaluation of necrotizing enterocolitis.

Pediatr Radiol

May 2024

Department of Radiology, Nemours Children's Health System, Florida, Orlando, FL, USA.

Background: Bowel ultrasound is a useful diagnostic tool in the diagnosis and management of necrotizing enterocolitis (NEC) but can be time-consuming and requires technical expertise, particularly for assessing pneumatosis. Previous literature on sonographic evaluation of NEC has focused on a full bowel ultrasound protocol, but the utility of an abbreviated protocol primarily aimed at identifying high-risk sonographic findings without focused bowel assessment has not been well studied.

Objective: This study aims to describe the diagnostic accuracy of an abbreviated ultrasound protocol for identifying high-risk NEC findings.

View Article and Find Full Text PDF

Community Partnership to Co-Develop an Intervention to Promote Equitable Uptake of the COVID-19 Vaccine Among Pediatric Populations.

Dela J Public Health

March 2024

Center for Healthcare Delivery Science, Nemours Children's Hospital Delaware; Department of Pediatrics, Sidney Kimmel Medical College, Thomas Jefferson University.

Objective: To describe the process of engaging community, caregiver, and youth partners in codeveloping an intervention to promote equitable uptake of the COVID-19 vaccine in non-Hispanic Black (Black) and Hispanic youth who experience higher rates of COVID-19 transmission, morbidity, and mortality but were less likely to receive the COVID-19 vaccine.

Methods: A team of 11 Black and Hispanic community partners was assembled to codevelop intervention strategies with our interdisciplinary research team. We used a mixed-methods crowdsourcing approach with Black and Hispanic youth (n=15) and caregivers of Black and Hispanic youth (n=20) who had not yet been vaccinated against COVID-19, recruited from primary care clinics, to elicit perspectives on the acceptability of these intervention strategies.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on the prevalence and health outcomes of men with 47,XXY and 47,XYY syndromes, two types of sex chromosome aneuploidies often associated with tall stature and poor health-related quality of life.
  • Conducted within the Million Veteran Program, it aims to identify both diagnosed and undiagnosed cases, analyze their military service metrics, and compare their health outcomes to matched controls.
  • Out of over 595,000 participants, the study found significant numbers of individuals with these syndromes, with higher prevalence in those of East Asian and European descent, while also tracking their health complications and mortality rates.
View Article and Find Full Text PDF

Purpose: Foot deformities are prevalent in children with cerebral palsy, but there is limited research on the progression of foot posture during growth. Our study aimed to evaluate the change in dynamic foot posture in children with cerebral palsy.

Methods: Children with cerebral palsy, aged 17-40 months, were recruited to participate in this Institutional Review Board-approved prospective longitudinal study by having serial foot posture evaluations.

View Article and Find Full Text PDF

Purpose: We examine referral sources and clinical characteristics for youth presenting to an outpatient interdisciplinary pediatric chronic pain program.

Patients And Methods: Referral data were extracted from the electronic health record. PROMIS Pediatric Anxiety and Pain Interference Scales were administered at an initial evaluation visit.

View Article and Find Full Text PDF

Restrictive abortion laws have impacts reaching far beyond the immediate sphere of reproductive health, with cascading effects on clinical and ethical aspects of neonatal care, as well as perinatal palliative care. These laws have the potential to alter how families and clinicians navigate prenatal and postnatal medical decisions after a complex fetal diagnosis is made. We present a hypothetical case to explore the nexus of abortion care and perinatal care of fetuses and infants with life-limiting conditions.

View Article and Find Full Text PDF

Becker muscular dystrophy (BMD) is an X-linked recessive disorder responsible for mild skeletal muscle involvement and variable degree of cardiomyopathy. The characteristics of cardiac phenotype of BMD in childhood remain elusive. Clinical manifestations, genotype, serum biomarkers, and echocardiogram were retrospectively reviewed in BMD patients.

View Article and Find Full Text PDF
Article Synopsis
  • The "Early Care (0-3 years) in Duchenne Muscular Dystrophy" meeting aimed to tackle the challenges of diagnosing and caring for young children with DMD and female carriers.
  • Experts discussed issues like diagnostic delays, the lack of guidelines, and the importance of timely interventions such as newborn screening and early corticosteroid therapy.
  • The meeting highlighted the need for better clinical support for families, individualized care plans, and ongoing research into potential treatments for DMD in infants and young boys.
View Article and Find Full Text PDF

Novel Compound Heterozygous ZAP70 R37G A507T Mutations in Infant with Severe Immunodeficiency.

J Clin Immunol

December 2023

Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.

Zeta-chain associated protein kinase 70 kDa (ZAP70) combined immunodeficiency (CID) is an autosomal recessive severe immunodeficiency that is characterized by abnormal T-cell receptor signaling. Children with the disorder typically present during the first year of life with diarrhea, failure to thrive, and recurrent bacterial, viral, or opportunistic infections. To date, the only potential cure is hematopoietic stem cell transplant (HSCT).

View Article and Find Full Text PDF

Hematopoietic Bone Marrow Transplant to Treat Systemic EBV-positive T-cell Lymphoma of Childhood.

J Pediatr Hematol Oncol

March 2024

Department of Pathology Division of Pediatric Hematology/Oncology, Nemours Center for Cancer and Blood Disorders, Nemours Children's Hospital-Delaware, Wilmington, DE.

Systemic Epstein-Barr virus-positive T-cell lymphoma of childhood (S-EBV-TCL) is a rare disease for which there is no standard of care. S-EBV-TCL is often associated with hemophagocytic lymphohistiocytosis and is generally thought of on the spectrum of EBV-related disease. For the few reported cases of cure in the literature, hematopoietic stem cell transplant has been required because it is the only treatment that has induced complete remission in patients suffering from EBV-associated T-cell or natural killer cell lymphoproliferative diseases, except hemophagocytic lymphohistiocytosis.

View Article and Find Full Text PDF