Stat3 Induces IL-10 and SR-A/CD204 Expression in Silica Nanoparticle-Triggered Pulmonary Fibrosis through Transactivation.

Inhalation of silica dust in the workplace has been addressed as a serious occupational pulmonary disease subsequently leading to inflammation and fibrosis. Enhanced expression of IL-10 significantly contributes to the disease etiology, along with an elevated Th2-type paradigm. Previously, we showed that the exaggerated Th2-type response was also associated with consistent upregulation of Stat3 in mouse airways stimulated with silica microparticles.

Unlocking the potential of SiO and CeO nanoparticles for arsenic mitigation in Vigna mungo L. Hepper (Blackgram).

In this study, the interaction effects of NaAsO (1 and 5 μM), SiO NPs (10 and 100 mg/L) and CeO NPs (10 and 100 mg/L) were assessed in Vigna mungo (Blackgram). The treatment of NaAsO, SiO, CeO-NPs and combinations of NPs & As were applied to blackgram plants under hydroponic conditions. After its application, the morpho-physiological, antioxidant activity, and phytochemical study were evaluated.

Pivotal avenue for hybrid electron transport layer-based perovskite solar cells with improved efficiency.

This study conducted a simulative analysis of different hybrid perovskite solar cells with various hybrid electron transport layers (ETL) and hole transport layers (HTL). The electron transport layer boosts durability, lowers production costs, increases stability, improves light absorption, and increases efficiency. Hybrid ETLs are taken into consideration to improve the device's performance.

Synthesis and characterization of CeO and SiO nanoparticles and their effect on growth parameters and the antioxidant defense system in Vigna mungo L. Hepper.

Engineered nanoparticles (NPs) have recently attracted a lot of attention after being tested in various agricultural plants. This paper reports the green synthesis of CeO NPs and SiO NPs from leaf extracts of Nyctanthes arbor-tristis. The physical characteristics of the produced nanoparticles were then determined using UV-visible spectroscopy, transmission electron microscopy (TEM), fluorescence spectroscopy, and Fourier transform infrared spectroscopy (FTIR).

Nanotechnology: the Alternative and Efficient Solution to Biofouling in the Aquaculture Industry.

Biofouling is a global issue in aquaculture industries. It adversely affects marine infrastructure (ship's hulls, mariculture cages and nets, underwater pipes and filters, building materials, probes, and sensor devices). The estimated cost of managing marine biofouling accounts for 5-10% of production cost.

Organ-specific immune profiling of Leishmania donovani-infected hamsters.

Visceral leishmaniasis (VL) is a neglected disease with a broad spectrum of clinical manifestations and involvement of visceral organs. Organ-specific immune response against the Leishmania donovani (Ld) complex is not yet understood due to the unavailability of an appropriate experimental model. In reference to our recent work on comparing the hamster model with VL patients, it is now possible to understand immune profiling in different visceral organs.

Humic acid-mediated reduction in toxicity of CoO NPs towards freshwater and marine microalgae in surfactant mixed medium.

The ever-increasing applications of CoO nanoparticles (NPs) have posed a serious concern about their discharge in the aquatic environment and ecotoxic implications. Being toxic towards aquatic species, the impact of other aquatic components such as dissolved organic matter (DOM), salinity, and surfactants are not studied sufficiently for their effect on the stability and ecotoxicity of CoO NPs. The present study aims at the influence of humic acid (HA) on the toxicity of CoO NPs in freshwater (C.

Optimization, kinetics, and thermodynamics aspects in the biodegradation of reactive black 5 (RB5) dye from textile wastewater using isolated bacterial strain, Bacillus albus DD1.

This study is aimed to model and optimize the decolorization of reactive black 5 (RB5) dye using Bacillus albus DD1. The response surface methodology (RSM) along with rotatable central composite design (rCCD) is used to optimize the response, % decolorization with four input variables: (i) pH (5-9), initial dye concentration (50-500 ppm), the composition of yeast extract as nitrogen source (0.2-1%) and amount of bacterial inoculum (5-25% v/v).

Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection.

People suffering from malnutrition show compromised levels of ω-6 fatty acid and malnutrition is frequently observed among visceral leishmaniasis (VL) patients as disease inflicts primarily the socioeconomic destitute communities. Dietary linoleic acid (LA, 18:2; ω-6 fatty acid) is the principal source of essential fatty acid and its derivatives i.e.

Author Correction: Immunotoxicological impact and biodistribution assessment of bismuth selenide (BiSe) nanoparticles following intratracheal instillation in mice.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in visceral leishmaniasis.

Infection with L. donovani affects mainly visceral organs. Importantly, the parasitic load differs in different visceral organs; therefore there is a need to understand the organ specific immune regulation, particularly in the spleen and liver.

Comparison Between Immuno-Clinicopathological Features of Experimental and Human Visceral Leishmaniasis by Leishmania donovani.

Background: Current understanding of visceral leishmaniasis (VL) depends upon the experimental model. Different species of mouse and hamster have been used as model for VL. It is already evident that the mouse model of VL is not a true reflection of the pathology of human visceral leishmaniasis (HuVL).

Cheese whey to biohydrogen and useful organic acids: A non-pathogenic microbial treatment by L. acidophilus.

The burgeoning organic waste and continuously increasing energy demands have resulted in significant environmental pollution concerns. To address this issue, the potential of different bacteria to produce biogas/biohydrogen from organic waste can be utilized as a source of renewable energy, however these pathogenic bacteria are not safe to use without strict contact isolation. In this study the role of safe food grade lactic acid bacteria (Lactobacillus spp.

Dependence of parasite on host derived ATP: an overview of extracellular nucleotide metabolism in parasite.

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Colorimetric sensor for the detection of HS and its application in molecular half-subtractor.

Azine based new colorimetric sensor 1 for the detection of gasotransmitter HS has been reported. Sensor 1 used to detect the HS with a remarkable red shift of 105 nm in the absorption spectra with a colour change from light yellow to brown red. Importantly, rare example of azine derivative has been used as a colorimetric probe for HS detection using deprotonation mechanism.

Immunotoxicological impact and biodistribution assessment of bismuth selenide (BiSe) nanoparticles following intratracheal instillation in mice.

Variously synthesized and fabricated BiSe nanoparticles (NPs) have recently been explored for their theranostic properties. Herein, we investigated the long term in-vivo biodistribution of BiSe NPs and systematically screened its immune-toxic potential over lungs and other secondary organs post intratracheal instillation. X-Ray CT scan and ICP MS results revealed significant particle localization and retention in lungs monitored for 1 h and 6 months time period respectively.

Physicochemical, morphological, thermal and pasting characteristics of starches from moth bean () cultivars grown in India: an underutilized crop.

This is a first kind of study on genotype diversity of starches of Moth Bean an underutilized pulse of India. Physicochemical properties like amylose content (7.8-21.

Effect of pH on optimization of photofermentative hydrogen production by co-culture of Rhodobacter sphaeroides-NMBL-02 and Bacillus firmus-NMBL-03.

Rhodobacter sphaeroides NMBL-02, photosynthetic purple non sulfur (PNS) bacteria and associated Bacillus firmus NMBL-03 were isolated from water sample collected from 15-20 inches beneath the surface of ponds from Northern region of India in modified Sistrom's media (120 ml) containing 3 g/L malate and 1.2 g/L ammonium sulfate. The isolation was done in air tight serum bottles (120 ml) under tungsten bulb (1.

Effects of arsenic toxicity on morphological characters in blackgram (Vigna mungo L.) during early growth stage.

Blackgram is an important pulse crop of the tropic and sub-tropic area and has been identified as a potential crop in many countries. In the south-East Asia arsenic toxicity in soil and water is one of the most environmental problems. Crop productivity is highly affected by cultivation in arsenic polluted soil or irrigation through arsenic polluted water.

Genetic and epigenetic markers in colorectal cancer screening: recent advances.

Colorectal cancer (CRC) is a heterogenous disease which develops from benign intraepithelial lesions known as adenomas to malignant carcinomas. Acquired alterations in Wnt signaling, TGFβ, MAPK pathway genes and clonal propagation of altered cells are responsible for this transformation. Detection of adenomas or early stage cancer in asymptomatic patients and better prognostic and predictive markers is important for improving the clinical management of CRC.

Exploration of anti-Malassezia potential of Nyctanthes arbor-tristis L. and their application to combat the infection caused by Mala s1 a novel allergen.

Background: Malassezia commensal yeasts along with multitude of antigens have been found to be associated with various skin disorders including Pityriasis versicolor (PV). Amongst them Mala s1, a 37 kDa protein has been proved to be a major allergen reacting with a large panel of sera. However, there exists no therapeutic alternative to combat such problems in form of plant based natural compounds.