317 results match your criteria: "Necrotizing Sialometaplasia"
TGF-β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia.
J Pathol
July 2024
Section of Pathology, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, Fukuoka, Japan.
Article Synopsis
- - Necrotising sialometaplasia (NSM) is a non-cancerous growth mostly found in the minor salivary glands, presenting as swelling and potentially ulceration, often mimicking cancer like squamous cell carcinoma.
- - Histopathologically, NSM is characterized by lobular structures, acinar infarction, and changes in the salivary ducts, with an unknown cause that requires careful distinction from malignant conditions.
- - The study investigates the role of the TGF-β3 gene, finding that it is upregulated in NSM and may contribute to the condition by inhibiting cell growth and causing cell type changes during healing and tissue regeneration.
Necrotizing sialometaplasia on the hard palate after sequential induced vomiting: case study.
Braz J Otorhinolaryngol
April 2024
Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Article Synopsis
- * The condition usually affects minor salivary glands, particularly in the hard palate, but can occur in other areas with salivary tissue.
- * Local ischemia, often caused by dental procedures and anesthesia in the palate, is believed to be the main factor behind this condition's development.
Non-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Review.
Indian J Otolaryngol Head Neck Surg
September 2023
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Caf?, S/N, 14040-904 Ribeirão Preto, SP Brazil.
Article Synopsis
- Necrotizing sialometaplasia (NS) is a rare, self-limiting condition that mainly affects the minor salivary glands in the palate and is more common in men over 45 years old.
- *It typically appears as an ulcerative lesion but can also be non-ulcerated, making it critical to include in diagnoses when examining oral lesions.
- *A case involving a 50-year-old male with a non-ulcerated lesion on the hard palate highlighted differences in age and gender prevalence compared to traditional ulcerated cases, emphasizing the unique characteristics of NS.
Simultaneous presentation of dual pathologies within the oral cavity: an unusual and diagnostically challenging presentation.
Br Dent J
August 2023
School of Dentistry, University of Birmingham, Birmingham, UK; Periodontal Research Group, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom.
Article Synopsis
- - Necrotising sialometaplasia (NS) is a rare condition with limited understanding of its causes and effects, making diagnosis complex and essential for ruling out oral cancer.
- - A case study from Birmingham Dental Hospital involved a 22-year-old South Asian woman who experienced pain linked to her lower right third molar, initially misdiagnosed as a viral infection, but was ultimately found to have both NS and pericoronitis.
- - This report highlights the unique diagnosis and management of non-ulcerating NS along with pericoronitis, a combination not previously documented in scientific literature, showcasing the intricacies of diagnosing rare oral conditions.
Diagnostic dilemma: our experience with necrotising sialometaplasia.
BMJ Case Rep
March 2023
Otorhinolaryngology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
Article Synopsis
- A man in his 40s visited the outpatient department with a painful ulcer in his mouth that had persisted for a week.
- A hard palate ulcer was found during the examination, but it was not tender when touched, and blood tests showed normal results.
- The ulcer was surgically biopsied, revealing a reactive inflammatory issue without abnormal cells, and after weekly check-ups, the ulcer healed completely in four weeks without extra treatment.
Top 10 Nested Pattern Head and Neck Lesions to Notice.
Head Neck Pathol
March 2023
Department of Pathology, Cleveland Clinic, 9500 Euclid Ave L25, Cleveland, OH, 44195, USA.
Article Synopsis
- * A wide range of tumors with a nested appearance is discussed, including those with neuroendocrine and squamous differentiation, along with their specific characteristics important for diagnosis.
- * The article concludes by emphasizing the importance of understanding the morphologic and immunohistochemical features of these tumors to accurately identify and differentiate between them in clinical practice.
Ulcerative and Inflammatory Lesions of the Oral Mucosa.
Oral Maxillofac Surg Clin North Am
May 2023
Division of Oral and Maxillofacial Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Article Synopsis
- Ulcerated and inflammatory lesions in the mouth are common and require a thorough patient medical and social history for accurate diagnosis.
- Key factors to consider include the patient's habits, duration, location, focus of the lesions, and any associated symptoms.
- The article covers various types of oral lesions, including their clinical features, management strategies, and histopathological characteristics.
Necrotizing Sialometaplasia: A Diagnostic Challenge to Oral Physicians.
Cureus
December 2022
Oral Medicine and Radiology, Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Mission's Research Foundation, Salem, IND.
Article Synopsis
- Necrotizing sialometaplasia is a rare, self-limiting condition of minor salivary glands that can resemble cancer but often resolves on its own.
- Contributing factors to this disorder include chronic smoking, alcohol use, certain medical procedures, and the presence of ill-fitting dentures.
- In a case study, a 57-year-old male chronic smoker developed this condition on his hard palate, which was diagnosed through clinical and radiological methods, and he experienced healing in just three days without any medical intervention.
Necrotizing Sialometaplasia in a Medically Compromised Patient-A Potential Diagnostic Pitfall.
JAMA Otolaryngol Head Neck Surg
August 2022
Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Bilateral Asynchronous Necrotizing Sialometaplasia of the Buccal Mucosa: A Case Report and Literature Review.
Cureus
April 2022
Otolaryngology-Head and Neck Surgery, Children's Hospital and Medical Center, Omaha, USA.
Article Synopsis
- * A unique case involving a 19-year-old female with bilateral ulcerative lesions in her mouth, occurring weeks apart, is presented, highlighting the complexity of diagnosis.
- * After ruling out other possible causes like cancer and infections, the patient was treated with antibiotics and steroids, leading to symptom resolution, emphasizing the need to consider this condition in patients with oral ulcers.
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue.
Head Neck Pathol
March 2022
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.
The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections.
View Article and Find Full Text PDFA diagnostic error of a necrotizing sialometaplasia: Case report.
Ann Med Surg (Lond)
February 2022
Oral surgery department, Faculty of Dental Medicine-Rabat, Mohammed V University of Rabat, Morocco.
Article Synopsis
- Necrotizing sialometaplasia (NSM) is a benign but inflammatory condition affecting salivary glands, particularly the minor ones in the palate, which can resemble malignant tumors both in appearance and tissue analysis.
- A case presented involved a 26-year-old woman who underwent maxillectomy for a misdiagnosed NSM, initially thought to be carcinoma, leading to unnecessary aggressive treatment.
- Accurate diagnosis of NSM is crucial, emphasizing the significance of histopathological evaluation and immunohistochemistry to avoid misdiagnosis and inappropriate treatment.
Necrotizing sialometaplasia: A report of two cases and review of the literature.
Stomatologija
May 2023
Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000, Natal, RN, Brasil.
Article Synopsis
- Necrotizing sialometaplasia (NS) is a benign condition affecting salivary glands, but its symptoms can resemble malignant epithelial pathologies, making accurate diagnosis challenging.* -
- The article presents two cases: a 76-year-old woman with a painful ulcer on the hard palate initially suspected to be cancer and a 26-year-old man with an ulcer on the soft palate thought to be traumatic.* -
- In both cases, biopsies confirmed NS, highlighting the importance for dentists to recognize oral ulcers lasting over two weeks without a clear cause.*
Necrotizing sialometaplasia: A diagnostic challenge.
Oral Oncol
July 2021
Department of Clinical and Preventive Dentistry, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address:
Non-ulcerated necrotizing sialometaplasia may mimic a salivary gland tumor.
Autops Case Rep
April 2021
Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba, Departamento de Diagnóstico Oral, Piracicaba, SP, Brasil.
Article Synopsis
- Necrotizing sialometaplasia (NS) is a benign but inflammatory condition affecting minor salivary glands in the hard palate, characterized by a nodule that develops into a central ulcer.
- The most common cause of NS is an ischemic event, making diagnosis important to differentiate it from salivary gland tumors, especially malignant ones.
- A case study of a 32-year-old male with a painful, slightly elevated area on the hard palate led to a diagnosis of NS through incisional biopsy and histopathological analyses, highlighting the need for clinicians to consider NS in similar cases.
Necrotizing sialometaplasia-A self-limiting condition which poses a diagnostic dilemma.
Clin Case Rep
April 2021
Department of Oral Medicine and Radiology GDCRI Bangalore India.
Article Synopsis
- Necrotizing sialometaplasia can cause anxiety in individuals, particularly those who use tobacco.
- It's important to get a quick diagnosis to address any concerns about the lesion.
- Providing reassurance and proper counseling to the patient, along with treatment, is essential for their well-being.
Necrotizing sialometaplasia of the tonsillar pillar. An unusual case.
J Clin Exp Dent
February 2021
Full time Professor of Department of Oral Pathology and Oral Medicine, Graduate and Research Division, Dental School, National Autonomous University of Mexico. Mexico city, Mexico.
Article Synopsis
- Necrotizing Sialometaplasia (NS) is a rare but benign condition that affects salivary glands, causing painful ulcers that can look like cancerous lesions.* -
- Due to its inflammatory nature, NS usually resolves on its own and doesn't require treatment, which makes accurate diagnosis crucial to avoid unnecessary interventions.* -
- A unique case of recurrent NS in a 43-year-old man highlights the need for clinicians to consider NS in their diagnoses when encountering ulcers in the oral cavity, particularly on the tonsillar pillars.*
Necrotizing sialometaplasia: a case report of a non-ulcerated histopathological presentation.
Dermatol Online J
December 2020
Department of Propaedeutic and Integrated Clinic, Universidade Federal da Bahia, Salvador, Bahia.
Article Synopsis
- A 27-year-old woman experienced severe pain in her palate for two months and was found to have a firm nodule at the palatal junction measuring 2.5cm.
- An incisional biopsy was performed due to concerns about potential cancers, specifically mucoepidermoid carcinoma or squamous cell carcinoma, but the results indicated necrotizing sialometaplasia instead.
- The condition showed total remission after 39 days post-biopsy without any need for treatment and no relapses in the following two years.
[Immunohistochemical diagnosis of necrotizing sialometaplasia].
Stomatologiia (Mosk)
October 2020
National Medical Research Center of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Article Synopsis
- The article discusses a clinical case involving the rare condition of necrotizing sialometaplasia in the hard palate, emphasizing the need for accurate diagnosis.
- An immunohistochemical study was performed using specific antibodies to differentiate necrotizing sialometaplasia from squamous cell carcinoma, revealing low cell proliferation and notable expression patterns of various proteins.
- The findings indicate that specific antibody panels, particularly for proteins like Ki-67, P53, and cytokeratins-7 and 15, are effective tools for confirming a diagnosis of necrotizing sialometaplasia.
Necrotizing sialometaplasia - Case report.
J Dent Sci
September 2020
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Low-Level Laser Therapy Approach of Bilateral Necrotizing Sialometaplasia of the Hard and Soft Palates.
J Lasers Med Sci
June 2020
DDS, MSc, PhD, Superior School of Health Science, Amazonas State University, Av. Carvalho Leal, 1777, Cachoeirinha, Manaus-AM, 69065-001, Brazil.
Necrotizing sialometaplasia (NS) is a rare locally destructive inflammatory benign disease that commonly affects the minor salivary glands. It is frequently associated with the glands located in the posterior portion of the hard and soft palates. Low-level laser therapy (LLLT), also called photobiomodulation therapy (PBMT), has been deemed a substantial method for the regenerative wound process.
View Article and Find Full Text PDFA retrospective study of salivary gland diseases in 179 dogs (2010-2018).
J Vet Diagn Invest
July 2020
Department of Pathology (Lieske, Rissi) and Athens Veterinary Diagnostic Laboratory (Rissi), College of Veterinary Medicine, University of Georgia, Athens, GA.
Article Synopsis
- The study examines 179 cases of salivary gland diseases in dogs submitted to a veterinary diagnostic lab from 2010 to 2018, highlighting their clinical and pathological features.
- The majority of affected dogs were around 8.5 years old, with no significant patterns related to sex or breed; most submissions were due to regional swelling.
- Diagnoses included nonspecific sialoadenitis as the most common condition, with neoplasia being the second most frequent; most tumors were identified as epithelial and malignant, affecting primarily extraoral glands.
Necrotizing sialometaplasia: a malignant masquerade but questionable precancerous lesion, report of four cases.
BMC Oral Health
July 2020
Department of pathology, Seoul National University Boramae Hospital, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea.
Background: Necrotizing sialometaplasia (NSM) is an extremely rare benign lesion with an uncertain pathogenesis. The differential diagnosis of this lesion is challenging due to little familiarity with this entity and histologic similarity with carcinomas, especially mucoepidermoid carcinoma (MEC). The purpose of this study is to raise awareness about NSM, which is often overlooked or misdiagnosed as malignancy in a small biopsy.
View Article and Find Full Text PDFNecrotizing Sialometaplasia and Bulimia: A Case Report.
Medicina (Kaunas)
April 2020
Egas Moniz University Institute, 2829-511 Caparica, Portugal.
Article Synopsis
- Bulimia is a common eating disorder primarily affecting young women and can lead to various health issues.
- The report discusses a particular case where a bulimic woman developed necrotising sialometaplasia, a rare condition characterized by a hard palatal ulcer.
- It emphasizes the importance of thorough medical histories for accurate diagnosis, as the patient showed no significant systemic issues or weight changes.