73 results match your criteria: "Necrolytic Acral Erythema"
Bilateral Blistering Rash Following Gastric Bypass Procedure and Mushroom Soup Diet: Hepatitis C Virus-Seronegative Necrolytic Acral Erythema.
Cureus
July 2024
Department of Dermatology, James A. Haley Veterans' Hospital, Tampa, USA.
Article Synopsis
- * A case study discusses a 66-year-old patient who, after having gastric bypass surgery, developed NAE due to a poor diet limited to just mushroom soup for three months, without any history of hepatitis C.
- * The patient was treated with zinc replacement after other treatments failed, and showed significant improvement at follow-up, highlighting how NAE can occur from nutritional deficiencies outside of known viral infections like HCV.
Extrahepatic Manifestations of Chronic Hepatitis C Virus (HCV) Infection.
Cureus
March 2024
Rheumatology, Centinela Hospital, Los Angeles, USA.
Article Synopsis
- Hepatitis C virus (HCV) is a significant cause of serious liver diseases, such as chronic hepatitis and liver cirrhosis, as well as hepatocellular carcinoma.
- Chronic HCV infection is also linked to various extrahepatic conditions that can result in serious health issues, including cryoglobulinemia, autoimmune diseases, and cardiovascular problems.
- Understanding these extrahepatic manifestations is crucial for early diagnosis and effective anti-viral treatment, which can help reduce long-term complications related to chronic HCV infection.
Dermoscopy in Necrolytic Acral Erythema: A Case Report.
Dermatol Pract Concept
January 2024
Department of Pathology, AIIMS, Bathinda, India.
Article Synopsis
- Necrolytic acral erythema (NAE) is a rare skin condition often linked to hepatitis C virus (HCV), characterized by thick, scaly patches on the arms and legs.
- Some studies have documented occurrences of NAE without any HCV infection, indicating it may have other causes.
- This case study highlights a female patient diagnosed with NAE who also has hypothyroidism, but does not have HCV.
Trace element zinc and skin disorders.
Front Med (Lausanne)
January 2023
Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- - Zinc is an essential trace element that plays crucial roles in biological functions such as maintaining skin integrity and promoting enzymatic responses.
- - Deficiency in zinc can cause various skin diseases, with supplementation being increasingly recognized for treating a wide range of skin-related issues like infections, inflammation, and tumors.
- - Recent literature reviews suggest that zinc application in dermatology can provide valuable insights for effective treatment strategies.
COVID-19-associated necrolytic acral erythema with postvaccination exacerbation in a seronegative patient.
Br J Dermatol
November 2022
Department of Dermatology, Military Hospital, Jammu, India.
Zinc-Responsive Acral Hyperkeratosis: A Report of a Rare Entity.
Indian Dermatol Online J
November 2021
Department of Dermato-Venereo-Leprology, Government Medical College and Hospital, Nagpur, Maharashtra, India.
Article Synopsis
- - Chronic acral hyperkeratotic dermatosis includes conditions like lichen simplex chronicus (LSC), hypertrophic lichen planus (HLP), and psoriasis vulgaris (Ps), which typically respond to treatments such as topical corticosteroids and oral methotrexate.
- - Zinc-responsive acral hyperkeratosis is a new condition similar to these but does not respond to standard treatments and requires zinc supplementation for improvement.
- - Necrolytic acral erythema (NAE) is a rare condition often linked to hepatitis C, showing similar symptoms to zinc-responsive acral hyperkeratosis but differing in microscopic examination and also responding well to oral zinc.
Erythematous Plaques on Legs and Feet in a Patient With Hepatitis C.
Gastroenterology
July 2021
Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
[Neuroendorine paraneoplastic syndromes].
Hautarzt
April 2021
Medizinische Klinik B, Universitätsklinikum Münster, Münster, Deutschland.
Article Synopsis
- Neuroendocrine paraneoplastic syndromes (PNS) often affect the skin by causing various cutaneous signs due to the abnormal secretion of hormones that interact with skin receptors.
- Conditions like acromegaly and Cushing syndrome demonstrate distinct skin changes, while carcinoid tumors cause flushing and diarrhea, illustrating the importance of recognizing these signs for early diagnosis.
- The review emphasizes understanding the pathophysiology of neuroendocrine PNS, identifying differential diagnoses, and necessitates an interdisciplinary approach for effective patient care.
Necrolytic acral erythema in a patient with sarcoidosis.
JAAD Case Rep
November 2020
The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, New York.
Bilateral Foot Skin Eruption in a Hepatitis C Patient.
Clin Pract Cases Emerg Med
August 2020
Virginia Commonwealth University Health Systems, Department of Emergency Medicine, Richmond, Virginia.
Article Synopsis
- - A 58-year-old woman with a history of hepatitis C presented to the ER with a skin condition on her feet that had lasted for a year.
- - After a skin biopsy, she was diagnosed with Necrolytic Acral Erythema (NAE) and treated with clobetasol ointment, zinc supplements, and mupirocin, leading to symptom improvement.
- - NAE is a rare skin rash associated with hepatitis C, characterized by well-defined, thickened plaques on the top of the feet.
Necrolytic Acral Erythema in Association With Hypothyroidism.
JAMA Dermatol
November 2020
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Necrolytic Acral Erythema in Seronegative Hepatitis C Patient with Vitamin B12 Deficiency.
Indian Dermatol Online J
March 2020
Department of Dermatology, Command Hospital, Bengaluru, Karnataka, India.
Zinc-responsive necrolytic acral erythema in ovarian cancer.
J Dermatol
July 2020
Departments of, Department of, Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
Necrolytic Acral Erythema: Current Insights.
Clin Cosmet Investig Dermatol
April 2020
Department of Dermatology, Venereology and Leprosy, SN Medical College, Bagalkote 587102, Karnataka, India.
Article Synopsis
- Necrolytic acral erythema (NAE) is identified as a unique skin condition, characterized by well-defined hyperpigmented papules and plaques with thick scales on the feet, often linked to Hepatitis C virus (HCV) infection but can occur in those without HCV.* -
- Proposed causes for NAE include liver dysfunction leading to various metabolic issues, and it shares similarities with other skin conditions like necrolytic migratory erythema and acrodermatitis enteropathica.* -
- Dermoscopy can assist in diagnosing NAE, and treatment typically involves oral zinc therapy, which has shown effectiveness regardless of the patient’s HCV status or zinc levels.*
Necrolytic acral erythema in a Chinese patient with hepatitis C and hepatitis B virus coinfection.
An Bras Dermatol
October 2019
Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangdong Provincial Dermatology Hospital, Guangzhou, China.
Article Synopsis
- Necrolytic acral erythema is a skin condition linked to hepatitis C virus infection, frequently seen in Africa, particularly Egypt.
- This report details the first known case of this condition in a Chinese patient who is also infected with both hepatitis C (HCV) and hepatitis B (HBV).
- The goal is to raise awareness about recognizing necrolytic acral erythema among the Chinese population.
Symmetric acral annular erythema: a variant of erythema annulare centrifugum, necrolytic acral erythema or a distinct clinical entity?
Postepy Dermatol Alergol
April 2019
Department of Dermatology, University of Rzeszow, Rzeszow, Poland.
Rivaroxaban induced necrolytic acral erythema.
Postgrad Med J
October 2019
Dermatology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report.
World J Hepatol
February 2019
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Article Synopsis
- - Necrolytic acral erythema (NAE) is a rare skin disorder linked to hepatitis C virus (HCV) infection or zinc deficiency, marked by red or purple lesions mainly on the legs, and treated with steroids and zinc supplements.
- - A case study discusses a 66-year-old woman co-infected with HIV and HCV who presented with a painless rash; skin biopsies confirmed NAE, leading to treatment with prednisone and zinc that resolved her symptoms.
- - It highlights the importance for clinicians to recognize NAE in patients presenting with rashes, particularly those with HCV, due to its rarity and unclear pathogenesis in co-infected individuals.
Image Gallery: Seronegative necrolytic acral erythema.
Br J Dermatol
August 2018
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, China.
Necrolytic acral erythema leading to diagnosis of chronic hepatitis C.
Dig Liver Dis
August 2018
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:
Dermatologic Manifestations of Chronic Hepatitis C Infection.
Clin Liver Dis
August 2017
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA. Electronic address:
Article Synopsis
- * Lichen planus, affecting the skin and mucous membranes, is noted in 4% to 24% of those with chronic HCV, indicating a significant overlap.
- * Porphyria cutanea tarda, the most common type of porphyria, is thought to be exacerbated by HCV's effect on iron levels, while necrolytic acral erythema is another rare skin condition linked to the virus.
Necrolytic Acral Erythema in Seronegative Hepatitis C.
Case Rep Dermatol
March 2017
Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Article Synopsis
- Necrolytic acral erythema (NAE) is a unique skin condition linked primarily to hepatitis C virus (HCV), although its exact cause is not fully understood.
- A 64-year-old woman experienced chronic, mildly itchy brownish to red rashes on both sides of her ankles for seven months, which matched the clinical signs of NAE.
- Despite presenting with symptoms consistent with NAE, she tested negative for HCV, indicating that there may be other factors or conditions associated with NAE.
Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era.
J Eur Acad Dermatol Venereol
August 2017
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
Article Synopsis
- New all-oral direct-acting antivirals (DAAs) for hepatitis C (HCV) have emerged, significantly impacting treatment options for patients, including those with dermatologic issues.
- Dermatologists need to be aware of how these new HCV treatments can help manage related skin disorders like mixed cryoglobulinaemia, lichen planus, porphyria cutanea tarda, and necrolytic acral erythema.
- Although current data on DAAs for skin-related HCV effects are limited, there's evidence suggesting they may improve skin symptoms, particularly in mixed cryoglobulinaemia, which highlights the importance of screening for HCV in patients with these dermatologic conditions.