Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021.

COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.

Esthetic Twin Block Approach for Correction of Developing Class II Division 1 Malocclusion of an 11-year-old Female Patient: A Case Report.

Unlabelled: An 11-year-old female patient with developing class II division 1 malocclusion having retrognathic mandible and crowding in the lower arch, horizontal growth pattern, with convex profile, hyperactive mentalis muscle, positive visual treatment objective (VTO) in cervical vertebral maturation indicator (CVMI) stage 4 was planned to be treated using modification of conventional twin block appliance. Though a wide variety of myofunctional appliances like activator, Bionator, and Frankel appliances can be delivered to the patient, twin block appliance being a mechanofunctional appliance is routinely preferred by operators due to simplicity of its design and construction in comparison to other appliances. One of the biggest challenges in management of growing patients with skeletal class II malocclusion is the compliance of patients in wearing the myofunctional appliances.

A "Mismatched" connection: a rare case of indirect or dural carotid-cavernous fistula: a case based review.

Introduction And Importance: A carotid-cavernous sinus fistula is an abnormal connection between the internal or external carotid artery and the venous system of the cavernous sinus. It represents a rare entity, and it is often misdiagnosed due to its overlapping symptoms with other conditions such as cavernous sinus thrombosis or orbital inflammation. Cerebral angiography continues to be the gold standard for diagnosis and surgical planning in patients with CCF, and the endovascular trans-venous approach still represents the primary line of treatment.

A Prospective Randomised Clinical Trial Evaluating Pulpotomy in Primary Molars With Three Bioceramic Calcium Silicate Cements: 24 Month Follow-Up.

Background: In recent times, bioceramic calcium silicates have gained attention due to high success rates with pulpotomy in primary teeth.

Aims: To evaluate and compare the clinical and radiographic outcomes of three different bioceramic calcium silicate cements in vital deciduous teeth treated with pulpotomies over a period of 24 months.

Design: Children aged 4-9 years, with deep dentinal caries (ICDAS 4-6) in primary molars, having no history of spontaneous pain or signs of non-vitality were included in the study.

Understanding decision making for the use of atraumatic restorative approach based on non-clinical factors by Indian pedodontists - a conjoint analysis.

Background: Atraumatic Restorative Treatment (ART) approach is considered as one of the minimally invasive interventions. The success of restoration depends on various clinical factors like material, patient and operator factor. Conjoint analysis is a technique for measuring individual's preference structures via systematical variations of products attributes in an experimental design.

Evaluating anticancer potentials of potentized preparations in an in-vivo xenograft model.

Background: Xenografts in immunodeficient mice play a pivotal role in testing novel anti-cancer treatments. Xenograft models expedite the drug discovery process, offering a cost-effective alternative to conventional animal models and providing essential data for clinical trials. We have followed the approach described by the Developmental Therapeutics Program of the National Cancer Institute (NCI), USA to investigate the therapeutic responses.

Feasible Preparation of Naphthalimide-Functionalized Zeolitic Imidazolate Framework-8 for Control, and Fluorescence Detection of Virus: Optimization of Model Study.

The onset of the coronavirus has highlighted the critical need to swift diagnostic techniques to identify the virus. Metal Organic Frameworks (MOFs) have attracted considerable attention in the field of sensing due to the remarkable characteristics. The present research examines the microwave preparation of naphthalimide-functionalized zeolitic imidazolate framework-8 (NI/ZIF-8) to the detection of coronavirus as a probe.

A Comprehensive Review on Immunoregulatory Effects of Phytochemicals.

An efficient immune system in the host body plays a crucial role in the preservation of normal biological and immune reactions and processes, as well as the intrinsic environment. This is because the immune system is responsible for fighting off foreign invaders. A healthy immune system strengthens the body's defense against infections, illnesses, and other unwelcome pathogens, thereby reducing the risk of allergic reactions and autoimmune diseases.

RAPID-CRISPR: Highly Sensitive Diagnostic Assay for Detection of PML-RARA Isoforms in Acute Promyelocytic Leukemia.

Acute promyelocytic leukemia (APL), distinguished by the presence of PML-RARA fusion transcript, is a medical emergency due to its high early death rate, which is preventable when diagnosed early. Current diagnostic methods are precise and reliable but are time-intensive, require sophisticated instruments and analytical expertise. This study has Redefined APL IDentification by CRISPR system (RAPID-CRISPR) to rapidly (<3hrs) detect PML-RARA.

A Cross-sectional Study on Association of Iliopsoas Muscle Length with Lumbar Lordosis Among Desk Job Workers.

Background: Prolonged hours of sitting in sustained posture is a common job requirement of desk job workers. Potential risk of iliopsoas muscle shortening leading to lumbar hyperlordosis, which in turn may cause low-back pain was identified. Thus, this study determined association between iliopsoas muscle length and lumbar lordosis in desk job workers.

Advancements in Imaging and Neurosurgical Techniques for Brain Tumor Resection: A Comprehensive Review.

Brain tumor surgery has witnessed significant advancements over the past few decades, resulting in improved patient outcomes. Despite these advancements, brain tumors remain a formidable public health challenge due to their high morbidity and mortality rates. This review explores the evolution of neurosurgical techniques for brain tumor resection, emphasizing the balance between minimizing invasiveness and maximizing precision.

A Comprehensive Safety Assessment of Algae Protein from Picochlorum for Human Consumption.

The current trend happens to be that consumers are seeking nourishing, high quality sustainable protein sources to meet their nutritional needs, thus establishing a clear intent to broaden their protein horizon. Microalgae protein holds great promise in becoming the next vegan protein option. In the present study, protein extracted from the microalga Picochlorum maculatum has been thoroughly evaluated for its safety for human consumption through a battery of in-vivo and in-vitro tests.

Menopause and Oral Health: Clinical Implications and Preventive Strategies.

Menopause, occurring typically between the ages of 45 and 55 years, marks the end of a woman's reproductive years and is characterized by the cessation of menstruation and a significant decline in estrogen and progesterone production. These hormonal changes impact various aspects of health, including oral health. This review explores the clinical implications of menopause on oral health and outlines preventive strategies.

Discovery of novel pyrazoline insecticides.

Background: The pyrazoline insecticides, invented by Philips Duphar in the 1970s, provide excellent control of lepidopterans and coleopterans and introduced a novel mode of action (MoA) as sodium-channel-blocking insecticides, but were not commercialized due to unacceptable persistence. This MoA is less explored, with only two successfully commercialized insecticides derived from the pyrazoline class - the oxadiazine indoxacarb from FMC (developed by DuPont) and the semicarbazone metaflumizone, co-developed by BASF and Nihon Nohyaku.

Results: The design and synthesis of novel pyrazoline insecticides with improved biological efficacy and favorable environmental fate profile are described.

A Review of the Work of Dr. Jo E Frencken: The Pioneer of Atraumatic Restorative Treatment for Dental Caries.

Dr. Jo E Frencken is a stalwart in preventive dentistry and cariology. He has worked extensively in diagnosing, treating, and assessing outcomes related to dental caries.

Association of Body Mass Index between Adolescents and their Parents in Mumbai and Kolkata: A Population-based Study.

Introduction: Adolescent overweight and obesity as measured by body mass index (BMI) seem to be increasing at an alarming rate in urban populations. Parental BMI plays an important role in their adolescent's BMI. Overweight and obesity coexisting with undernutrition in adolescents is an important public health challenge in low- and middle-income countries (LMICs).

In silico screening of phytochemicals against chromatin modifier, SETD7 for remodeling of the immunosuppressive tumor microenvironment in renal cancer.

The tumor microenvironment and immune evasion function in a complex cellular network profoundly challenge the clinical outcome of promising therapies. Our recently published study reported that the subset of genes upregulated in ccRCC due to H3K4me1 and DNA demethylation potentially leads to an immunosuppressive environment. Thus, modulating H3K4me1 chromatin modifier SETD7 with a natural inhibitor in combination with immunotherapy might improve the immune landscape for a better therapeutic outcome.

Association between Body Mass Index (BMI) and waist circumference with leg power in cricketers.

Unlabelled: Cricket is one of the most well-known sports played in India. It not only comprises of aerobic activity but also includes complex-based movements like running, jumping, diving, catching, etc that depend on various individual factors such as height, weight, power, endurance, agility etc. OBJECTIVES: The purpose of the study was to determine the relationship between BMI, Waist circumference with leg power in cricket players.

Prevalence of neck pain in higher secondary students (8th to 12th standard) due to e-learning during the COVID-19 pandemic period: An online survey.

Introduction: Neck pain is a typical complaint among people who spend a lot of time on their devices. Due to the pandemic situation, students have recently shifted their studies from the classroom to e-learning, causing them to spend excessive hours on gadgets. Thus, it is of utmost importance to study the prevalence of neck pain in students using gadgets for e-learning.