Utilizing biomaterial surface properties to improve orthopedic hip implant safety and function in a Safe-by-Design approach.

Orthopedic hip implant failure due to adverse events, such as infection, are still a major problem leading to high morbidity and mortality. Over the years, various innovative biomaterials have been investigated to improve safety and functionality of implants. Although novel biomaterials show initial promising results, many fail at the (later) stages of safety testing.

Corrigendum to "A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health" [Eco-Environ. Health (2023)195-207].

[This corrects the article DOI: 10.1016/j.eehl.

Priming agents combat copper stress in wheat (Triticum aestivum L.) under hydroponic conditions: Insights in impacts on morpho-physio-biochemical traits and health risk assessment.

In recent years, the use of priming agents, such as silicon, melatonin, salicylic acid, glycine betaine, and ascorbic acid has gained significant attention for their role in mitigating abiotic stresses across various plant species. While previous research has been conducted on the individual impact of silicon, melatonin, salicylic acid, glycine betaine, and ascorbic acid in metal stress resistance among various crop species, their combined effects in the context of heavy metal stressed conditions remain underexplored. Wheat (Triticum aestivum L.

Modelling the size distribution and bioaccumulation of gold nanoparticles under mixture exposure.

To assess the bioaccumulation and toxicity of nanoparticles (NPs), analyzing and modelling the relationship between the size distribution of NPs in organisms and the exposure particle size distribution represents an important challenge. Previous studies mostly focused on the NPs with single size. However, the size distribution of NPs is wide and variable in the natural environment.

Predicting the dissolution of metal-based nanoparticles by means of QSPRs and the effect of data augmentation.

Particle dissolution is a critical process in the environmental fate assessment of metal-based nanoparticles (MNPs). Numerous attempts have been made previously to adequately quantify dissolution (kinetics), however, existing dissolution data and models are generally limited to a few nanomaterials or specific time points. Hence, they only capture phases of the process.

A health economic evaluation of the multinational, randomized controlled CONVINCE trial: cost-utility of high-dose online hemodiafiltration compared to high-flux hemodialysis.

High-flux hemodialysis (HD) and high-dose hemodiafiltration (HDF) are established treatments for patients with kidney failure. Since HDF has been associated with improved survival rates compared to HD, we evaluated the cost-effectiveness of HDF compared to HD. Cost-utility analyses were performed from a societal perspective alongside the multinational randomized controlled CONVINCE trial.

Investigating socioeconomic disparities in prescribing new diabetes medications in individuals with type 2 diabetes and very high cardiovascular risk in the Netherlands.

Aims: This study aims to analyze prescription patterns of new diabetes medication and assess socioeconomic disparities in their initiation among individuals with T2DM with very high cardiovascular risk.

Methods: Individuals diagnosed with T2DM and very high cardiovascular risk were identified (N = 10,768) based on general practitioner's electronic health record data. SGLT-2is and GLP-1RAs prescription patterns were examined.

In-situ and ex-situ EPS-corona formation on ZnO QDs mitigates their environmental toxicity in the freshwater microalgae Chlorella sp.

The current work seeks to understand how the interactions between ZnO QDs and extracellular polymeric substances (EPS) may vary based on the types of EPS (loosely and tightly bound) and modes of eco-corona formation (In-situ or ex-situ). In-situ eco-corona refers to formation of an EPS layer on the QDs during the interactions with the algae whereas the ex-situ condition refers to forming the layer before the interactions. ZnO QDs were added at 0.

Corrigendum to "Understanding frailty and its opposites from community-dwelling older people's perspectives: A phenomenological qualitative study" [International Journal of Nursing Studies Advances 7 (2024) 100238].

[This corrects the article DOI: 10.1016/j.ijnsa.

Microbial function matters: Microbiome-aware nano-ecotoxicology needs functional endpoints besides compositional data.

The microbiome provides an active barrier to the external environment and aids in the metabolism of the host. Nanomaterials are known to interact with this microbiome host plane. Given the recent advances in techniques to study the microbiome, there has been a vast increase in studies trying to find causality in host response via the microbiome in nano-ecotoxicology.

Quantifying aquifer heterogeneity using superparamagnetic DNA particles.

Identifying and determining hydraulic parameters of physically heterogeneous aquifers is pivotal for flow field analysis, contaminant migration and risk assessment. In this research, we applied a novel uniquely sequenced DNA tagged superparamagnetic silica microparticles (SiDNAmag) to quantify hydraulic parameters and associated uncertainties of a heterogeneous sand tank. In the sand tank with lens shaped heterogeneity, we conducted three sets of multi - point injection experiments in unconsolidated (1) homogeneous (zone 0), (2) heterogeneous with a no-conductivity-zone (zone 1), and (3) heterogeneous with a high-conductive-zone (zone 2).

Easy-MODA: Simplifying standardised registration of scientific simulation workflows through MODA template guidelines powered by the Enalos Cloud Platform.

Modelling Data (MODA) reporting guidelines have been proposed for common terminology and for recording metadata for physics-based materials modelling and simulations in a CEN Workshop Agreement (CWA 17284:2018). Their purpose is similar to that of the Quantitative Structure-Activity Relationship (QSAR) model report form (QMRF) that aims to increase industry and regulatory confidence in QSAR models, but for a wider range of model types. Recently, the WorldFAIR project's nanomaterials case study suggested that both QMRF and MODA templates are an important means to enhance compliance of nanoinformatics models, and their underpinning datasets, with the FAIR principles (Findable, Accessible, Interoperable, Reusable).

Differential Leaf-to-Root Movement, Trophic Transfer, and Tissue-Specific Biodistribution of Metal-Based and Polymer-Based Nanoparticles When Present Singly and in Mixture.

The transfer of nanoparticles (NPs) through the terrestrial food chain via foliar uptake presents poorly understood risks, especially in scenarios involving copollution and plant translocation. Herein, we exposed the radishes to single and mixed foliar doses of CeO NPs and deuterated polystyrene (DPS), investigating the trophic transfer of NPs from radish shoots/roots to snails. Compared to single treatments, mixture treatments increased Ce uptake by plants but had no effect on DPS uptake.

Accessible viral metagenomics for public health and clinical domains with Jovian.

The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. To address these challenges, we developed Jovian, an open-source, virus-focused, metagenomic analysis workflow for Illumina data. Jovian generates scaffolds enriched with pertinent annotations, including taxonomic classification, combined with metrics needed for quality assessment (coverage depth, average GC content, localization of open reading frames, minority single nucleotide polymorphisms), and incorporates host and disease metadata.

The impact of frailty on the use of social services, medication and mortality risk: a cross-sectional study.

Background: Frailty is a common condition in older people, and its prevalence increases with age. With an ageing population, the adverse consequences of frailty cause an increasing appeal to the health care system. The impact of frailty on population level is often assessed using adverse health outcomes, such as mortality and medication use.

Fibrous microplastics in the environment: Sources, occurrence, impacts, and mitigation strategies.

Fibrous microplastics (FMPs), a unique class of microplastics, are increasingly recognized as a significant environmental threat due to their ubiquitous presence and potential risks to ecological and human health. This review provides a comprehensive overview of FMPs, including their sources, prevalence in various environmental media, and potential impacts. FMPs, which can be found in over 90 % of certain environmental samples, originate from a diverse range of sources, including synthetic textiles, landfill waste, industrial emissions, and atmospheric deposition.

Quantitative tracking of nanoplastics along the food chain from lettuce (Lactuca sativa) to snails (Cantareus aspersus).

Terrestrial systems are a significant sink for plastic contamination, including nano- and microplastics (NMPs). To date, limited information is available about the transfer of NMPs up the food web via trophic transfer, however, concerns about this exposure pathway for invertebrates and higher-level organisms have been raised. We aim to examine and quantify the trophic transfer of europium doped polystyrene nanoplastics (Eu-PS; NPs) within a terrestrial food chain.

Sludge size affects sorption of organic micropollutants in full-scale aerobic granular sludge systems.

Aerobic granular sludge (AGS) is gaining popularity as an alternative to activated sludge for wastewater treatment. However, little information is available on AGS regarding the removal of organic micropollutants (OMPs) through sorption. In this study, the sorption behavior of 24 OMPs at environmentally relevant concentrations (1 μg/L) was investigated in six sludge fractions of varying sizes (>4 mm, 2-4 mm, 1-2 mm, 0.

Accumulation kinetics of polystyrene nano- and microplastics in the waterflea Daphnia magna and trophic transfer to the mysid Limnomysis benedeni.

Despite the pervasive presence of nano- and microplastics (NMPs) in aquatic environments, their movement through food chains remains poorly understood. In this study, we explored the uptake of polystyrene plastics (PSPs) of varying sizes (26, 500, and 4800 nm) in Daphnia magna and their subsequent transfer to the freshwater mysid Limnomysis benedeni, shedding light on the intricate dynamics of NMP transfer in freshwater ecosystems. Our results show that in D.

Understanding frailty and its opposites from community-dwelling older peoples' perspectives: A phenomenological qualitative study.

Background: the global population is ageing. As older people become more susceptible to frailty, an increase in frailty prevalence is also expected. Although frailty has been defined before in research, older peoples' perceptions of frailty do not always coincide with those used in research or medical settings.

The DECISION project: DiscrEte Choice experIment Spinal manipulative therapy for lOw back paiN: A study protocol.

The smallest worthwhile effect (SWE) is the smallest beneficial effect of an intervention that justifies the costs, risks, and inconveniences. The objective is to establish the SWE of spinal manipulative therapy (SMT) for the treatment of low back pain (LBP), and to gain insight into how different attributes of the treatment are traded among each other when choosing SMT. Part 1.

Modeling the Toxicokinetics of Suspensions of Soluble Metallic Nanomaterials.

Proper risk assessment of the many new nanoforms (NFs) that are currently being developed and marketed is hindered by constraints in time and resources for testing their fate and (eco) toxicity profile. This problem has also been encountered in conventional chemical risk assessments, where the definition of related chemical groups can facilitate risk assessment for all class members. Whereas grouping and read-across methods are well established, such approaches are in the early stages of development for NFs.

Perspectives on Advancing Multimodal Learning in Environmental Science and Engineering Studies.

The environment faces increasing anthropogenic impacts, resulting in a rapid increase in environmental issues that undermine the natural capital essential for human wellbeing. These issues are complex and often influenced by various factors represented by data with different modalities. While machine learning (ML) provides data-driven tools for addressing the environmental issues, the current ML models in environmental science and engineering (ES&E) often neglect the utilization of multimodal data.