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Associations of Blood Cardiovascular Biomarkers With Brain Free Water and Its Relationship to Cognitive Decline: A Diffusion-MRI Study.
Neurology
July 2023
From the Centre for Sleep and Cognition (F.J., S.L., M.O., J.H.Z.), Yong Loo Lin School of Medicine, National University of Singapore; Memory Aging & Cognition Centre (Y.L.C., C.N.K., N.V., C.C., M.K.P.L.), National University Health System; Department of Pharmacology (Y.L.C., C.N.K., C.C., M.K.P.L.), Yong Loo Lin School of Medicine, and Cardiovascular Research Institute (A.M.R.), National University of Singapore; Christchurch Heart Institute (A.M.R.), University of Otago, New Zealand; St Luke's Hospital (B.Y.T.); Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Departments of Psychiatry and Radiology (O.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Centre for Translational MR Research (S.L., J.H.Z.), Yong Loo Lin School of Medicine, Duke-NUS Medical School (J.H.Z.), and Integrative Sciences and Engineering Programme (ISEP) (J.H.Z.), National University of Singapore.
Background And Objectives: There is an increasing awareness of the "Heart-Brain Connection," whereby cardiovascular function is connected with cognition. Diffusion-MRI studies reported higher brain free water (FW) was associated with cerebrovascular disease (CeVD) and cognitive impairment. In this study, we investigated whether higher brain FW was related to blood cardiovascular biomarkers and whether FW mediated the associations between blood biomarkers and cognition.
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