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Parametric mapping for 11C-metomidate PET-computed tomography imaging in the study of primary aldosteronism.

Nucl Med Commun

August 2021

Siemens Medical Solutions, Malvern, Pennsylvania, USA Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore.

Objective: 11C-metomidate (11C-MTO) PET-computed tomography (CT) imaging has shown good sensitivity and specificity for the classification of bilateral or unilateral overexpression of aldosterone. This work seeks to investigate the usefulness of parametric maps via kinetic modeling of 11C-metomidate data into the clinical diagnosis pathway.

Methods: Twenty-five patients were injected with 172 ± 12 MBq of 11C-metomidate and a dynamic PET scan performed of the adrenal glands.

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