Site-Selective Modification and Labeling of Native RNA.

Ribonucleic acid (RNA) plays a pivotal role in regulating biological processes within living systems, with modified nucleosides serving as critical modulators of various aspects of biological functions. Therefore, the development of efficient methodologies for late-stage, site-selective RNA modification is of considerable interest, as it facilitates the functional exploration of RNA chemical modifications and their implications for therapeutic applications. Precise RNA modification holds significant promise for the treatment of genetic diseases by enabling the correction of mutated nucleobases to their wild-type forms.

Crystalline, Porous Figure-Eight-Noded Covalent Organic Frameworks.

Figure-eight macrocycles represent a fascinating class of π-conjugated units characterized by unique aesthetics and non-contact molecular crossing at the center. Despite progress in synthesis over the past century, research into inorganic, organic, and polymeric figure-eight materials remains in its infancy. Here we report the first examples of figure-eight covalent organic frameworks by condensing figure-eight knots to create extended porous figure-eight π architectures.

Why did COVID-19 not further harm the mental health of poor mothers? A mixed-method study on low-income families in Singapore.

Objectives: This paper examines the impact of COVID-19 pandemic on a disadvantaged group of financially poor mothers' mental health conditions in Singapore during the phase of acute COVID-19 infection.

Design: A mixed-method design is used. We conducted five focus group discussions with interviewers (n=39) who administered a third wave of survey questionnaire to 424 mothers from low-income families between June and September 2020.