1 results match your criteria: "National University of Singapore (NUS) and NUS-HUJI Singapore.[Affiliation]"
Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus.
Front Cell Infect Microbiol
March 2015
Department of Microbiology and Molecular Genetics, Faculty of Medicine, The Hebrew University of Jerusalem (HUJI) Jerusalem, Israel ; Department of Microbiology, Center for Research Excellence and Technological Enterprise (CREATE), National University of Singapore (NUS) and NUS-HUJI Singapore.
The connection between bacterial pathogens and unfolded protein response (UPR) is poorly explored. In this review we highlight the evidence showing that group A streptococcus (GAS) induces endoplasmic reticulum (ER) stress and UPR through which it captures the amino acid asparagine (ASN) from the host. GAS acts extracellularly and during adherence to host cells it delivers the hemolysin toxins; streptolysin O (SLO) and streptolysin S (SLS).
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