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421 results match your criteria: "National University of Ireland Maynooth[Affiliation]"
Comput Biol Med
December 2024
Department of Management Information Systems (MIS), School of Business, King Faisal University (KFU), Al-Ahsa, 31982, Saudi Arabia. Electronic address:
N4-methylcytosine (4mC) is a chemical modification that occurs on one of the four nucleotide bases in DNA and plays a vital role in DNA expression, repair, and replication. It also actively participates in the regulation of cell differentiation and gene expression. Consequently, it is important to comprehend the role of 4mC in the epigenetic regulation for revealing the complications of the gene expression and their associated governing cellular operations.
View Article and Find Full Text PDFJ Sleep Res
October 2024
Academic Department of Endocrinology and Diabetes Mellitus, Connolly Hospital Blanchardstown, Dublin, Ireland.
Circadian disruption, arising from conflict between internal circadian time and behavioural sleep-wake and fasting-feeding rhythms, may contribute to the prevalence of type 2 diabetes mellitus and disease severity. Previous studies have demonstrated a link between irregular breakfast eating and poorer metabolic health. We aimed to further explore the relationships between breakfast habits, circadian misalignment (social jetlag), and metabolic parameters in a cohort of adult participants with type 2 diabetes mellitus.
View Article and Find Full Text PDFMucosal Immunol
September 2024
Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, National University of Ireland Maynooth, Co. Kildare, Ireland; Gastrointestinal Eosinophilic Diseases Program, Digestive Health Institute, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, CO, USA. Electronic address:
Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We found that macrophage accumulation precedes esophageal fibrosis in FS-EoE patients.
View Article and Find Full Text PDFSensors (Basel)
April 2024
Core Research Institute of Intelligent Robots, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Unsupervised anomaly detection in multivariate time series sensor data is a complex task with diverse applications in different domains such as livestock farming and agriculture (LF&A), the Internet of Things (IoT), and human activity recognition (HAR). Advanced machine learning techniques are necessary to detect multi-sensor time series data anomalies. The primary focus of this research is to develop state-of-the-art machine learning methods for detecting anomalies in multi-sensor data.
View Article and Find Full Text PDFRSC Chem Biol
April 2024
Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick Ireland.
Ruthenium(ii) complexes are attracting significant research attention as a promising class of photosensitizers (PSs) in photodynamic therapy (PDT). Having previously reported the synthesis of two novel Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's base compounds 1 and 2 with interesting photophysical properties, where the emission from either the Ru(ii) polypyridyl centres or the naphthalimide moieties could be used to monitor binding to nucleic acids, we sought to use these compounds to investigate further and in more detail their biological profiling, which included unravelling their mechanism of cellular uptake, cellular trafficking and cellular responses to photoexcitation. Here we demonstrate that these compounds undergo rapid time dependent uptake in HeLa cells that involved energy dependent, caveolae and lipid raft-dependent mediated endocytosis, as demonstrated by confocal imaging, and transmission and scanning electron microscopy.
View Article and Find Full Text PDFPhys Chem Chem Phys
April 2024
Department of Experimental Physics, National University of Ireland Maynooth, Maynooth, Co, Kildare, Ireland.
We have performed coincidence mass spectrometry of fragmentation of pyrene molecules by 70 eV electron impact. Ionized fragments have been mass selected using a reflectron time-of-flight mass spectrometer, and a field programmable gate array has been used for the timing of the electron and ion extraction pulses and for the event-by-event detection of the ions. Double ionization results in a number of prominent fragmentations producing two singly-ionized fragments with kinetic energies of up to a few eV.
View Article and Find Full Text PDFMethodsX
December 2023
Naturally Inspired Computation Research Group, Department of Computer Science, Hamilton Institute, National University of Ireland Maynooth, Lero, Ireland.
NetworkX are probably the most popular approaches in industry for creating hapefiles (Geospatial Vector Data In this study,•We outline a flexible method that can be used to easily create graphical network representations in NetworkX or using road network topology data stored in ESRI Shapefiles• successfully transform the ESRI Shapefile data into the compatible format for graph analysis libraries like OSMnx and NetworkX.• without distorting the actual structure of the graph.This method will allow efficiencies of different sizes and topologies.
View Article and Find Full Text PDFFungal Genet Biol
December 2023
Department of Plant Pathology, University of Wisconsin, Madison, WI, USA; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA. Electronic address:
Epigenetic modification of chromosome structure has increasingly been associated with alterations in secondary metabolism and sporulation defects in filamentous fungal pathogens. Recently, the epigenetic reader protein SntB was shown to govern virulence, spore production and mycotoxin synthesis in the fruit pathogen Penicillium expansum. Through immunoprecipitation-coupled mass spectrometry, we found that SntB is a member of a protein complex with KdmB, a histone demethylase and the essential protein RpdA, a histone deacetylase.
View Article and Find Full Text PDFJ Environ Manage
November 2023
School of Geography, Newman Building, Belfield, University College Dublin, Ireland. Electronic address:
Research producing evidence-based information on the health benefits of green and blue spaces often has within its design, the potential for inherent or implicit bias which can unconsciously orient the outcomes of such studies towards preconceived hypothesis. Many studies are situated in proximity to specific or generic green and blue spaces (hence, constituting a green or blue space led approach), others are conducted due to availability of green and blue space data (hence, applying a green or blue space data led approach), while other studies are shaped by particular interests in the association of particular health conditions with presence of, or engagements with green or blue spaces (hence, adopting a health or health status led approach). In order to tackle this bias and develop a more objective research design for studying associations between human health outcomes and green and blue spaces, this paper discussed the features of a methodological framework suitable for that purpose after an initial, year-long, exploratory Irish study.
View Article and Find Full Text PDFPest Manag Sci
December 2023
Department of Invertebrate Pests and Weeds in Forestry, Agriculture and Horticulture, Norwegian Institute of Bioeconomy Research, Ås, Norway.
Background: Integrated pest management (IPM) has a long history in fruit production and has become even more important with the implementation of the EU directive 2009/128/EC making IPM mandatory. In this study, we surveyed 30 apple orchards in Norway for 3 years (2016-2018) monitoring pest- and beneficial arthropods as well as evaluating fruit damage. We obtained growers' diaries of pest management and used these data to study positive and negative correlations of pesticides with the different arthropod groups and damage due to pests.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2023
Department of Immunology, State Key Laboratory of Reproductive Medicine and Offspring Health, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Gusu School, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing, 211166, China.
The intestinal epithelium is the fastest renewing tissue in mammals and its regenerative process must be tightly controlled to minimize the risk of dysfunction and tumorigenesis. The orderly expression and activation of Yes-associated protein (YAP) are the key steps in driving intestinal regeneration and crucial for intestinal homeostasis. However, the regulatory mechanisms controlling this process remain largely unknown.
View Article and Find Full Text PDFIr J Psychol Med
June 2023
Recovery and Engagement Lead, Office of Mental Health Engagement and Recovery, HSE, Dublin, Ireland.
PLoS One
February 2023
School of Public Policy and Administration, Carleton University, Ottawa, Canada.
Recent research has shown that organizational leaders' tweets can influence employee anxiety. In this study, we turn the table and examine whether the same can be said about followers' tweets. Based on emotional contagion and a dataset of 108 leaders and 178 followers across 50 organizations, we infer and track state- and trait-anxiety scores of participants over 316 days, including pre- and post the onset of the SARS-CoV-2 pandemic and crisis.
View Article and Find Full Text PDFMethods Mol Biol
November 2022
Department of Biology, Maynooth University, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Two-dimensional difference gel electrophoresis (2D-DIGE) is a high-resolution protein separation technique, with the excellent dynamic range obtained by fluorescent tag labeling of protein samples. Scanned images of 2D-DIGE gels show thousands of protein spots, each spot representing a single or a group of protein isoforms. By using commercially available software, each protein spot is defined by an outline, which is digitized and correlated with the quantity of proteins present in each spot.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
November 2022
Department of Immunology, Key Laboratory of Immunological Environment and Disease, Gusu School, State Key Laboratory of Reproductive Medicine, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, Nanjing Medical University, 211166 Nanjing, China.
Inflammatory pathways usually utilize negative feedback regulatory systems to prevent tissue damage arising from excessive inflammatory response. Whether such negative feedback mechanisms exist in inflammasome activation remains unknown. Gasdermin D (GSDMD) is the pyroptosis executioner of downstream inflammasome signaling.
View Article and Find Full Text PDFPLoS One
September 2022
School of Business, National University of Ireland Maynooth, Maynooth, Ireland.
In this paper, we explore the role of perceived emotions and crisis communication strategies via organizational computer-mediated communication in predicting public anxiety, the default crisis emotion. We use a machine-learning approach to detect and predict anxiety scores in organizational crisis announcements on social media and the public's responses to these posts. We also control for emotional and language tones in organizational crisis responses using a separate machine learning algorithm.
View Article and Find Full Text PDFActa Psychol (Amst)
October 2022
Western Governors University, Salt Lake City, USA.
The existing literature has explored the role and importance of personality traits in leader prototypicality. However, limited research exists concerning the link between personality traits and leader emergence or prototypicality in ad hoc teams. Based on the relational leadership and attachment literature, we examine whether leader attachment orientations can serve as antecedents of leader prototypicality in ad hoc teams.
View Article and Find Full Text PDFOrg Biomol Chem
September 2022
Department of Chemistry, National University of Ireland Maynooth, Maynooth, Ireland.
Stimuli responsive anion transport is becoming an important aspect of supramolecular anion recognition chemistry. Herein, we report the synthesis of a family of anion receptors that incorporate a new anion binding motif, amidosquaramides. We show using experimental and computational methods that these receptors have p values close to physiological pH but also display intramolecular H-bonding interactions that affect anion recognition.
View Article and Find Full Text PDFBMC Res Notes
August 2022
ALL Institute, Maynooth University, National University of Ireland Maynooth, Maynooth, Ireland.
BMC Res Notes
July 2022
ALL Institute, Maynooth University, National University of Ireland Maynooth, Maynooth, Ireland.
Objective: Despite considerable spending on mental health in the Netherlands, access to mental health remains suboptimal, particularly for migrants and ethnic minorities. Addressing the growing mental health service needs requires an understanding of the experiences of all stakeholders, specifically minority populations. In this exploratory study, we sought to understand the perspectives and experience of mental health services by migrants and their provider.
View Article and Find Full Text PDFBMJ Open Gastroenterol
May 2022
Department of Hepatology, St James's Hospital, Dublin, Ireland
PLoS One
March 2022
Birmingham City Business School, Birmingham City University, Birmingham, United Kingdom.
Do organizational leaders' tweets influence their employees' anxiety? And if so, have employees become more susceptible to their leader's social media communications during the COVID-19 pandemic? Based on emotional contagion and using machine learning algorithms to track anxiety and personality traits of 197 leaders and 958 followers across 79 organizations over 316 days, we find that during the pandemic leaders' tweets do influence follower state anxiety. In addition, followers of trait anxious leaders seem somewhat protected by sudden spikes in leader state anxiety, while followers of less trait anxious leaders are most affected by increased leader state anxiety. Multi-day lagged regressions showcase that this effect is stronger post-onset of the COVID-19 pandemic compared to the pre-pandemic crisis context.
View Article and Find Full Text PDFChronobiol Int
April 2022
Department of Psychology, Maynooth University, National University of Ireland Maynooth, Kildare, Ireland.
Sleep is increasingly recognised as an important risk factor for metabolic disease, and as an important influence on severity in established metabolic disease. Recent evidence suggests that sleep timing variability (the day-to-day fluctuations of sleep timing) may be an important factor in metabolic diseases such as type 2 diabetes mellitus. In the current study, we explore the associations between measures of sleep timing variability and cardiometabolic measures in a group of healthy middle-aged adults with and without type 2 diabetes mellitus.
View Article and Find Full Text PDF