2 results match your criteria: "National University Singapore. Electronic address: Boon_Cher_Goh@nuhs.edu.sg.[Affiliation]"
Is abundance of B cells the best biomarker to predict immune checkpoint inhibitor response in head and neck squamous cell cancers?
Ann Oncol
January 2025
National University Cancer Institute Singapore; Cancer Science Institute Singapore, National University of Singapore; Department of Pharmacology, Department of Medicine, National University Singapore. Electronic address:
Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance.
Redox Biol
July 2019
Department of Physiology and Medical Science Cluster Cancer ProgramYong Loo Lin School of Medicine, National University of Singapore, Singapore 119753, Singapore; NUS Graduate School for Integrative Sciences and Engineering, Singapore 117456, Singapore; National University Cancer Institute, National University Health System, Singapore 119074, Singapore; Curtin Health Innovation Research Institute and School of Pharmacy and Biomedical Sciences, Curtin University, Perth 6102, Australia. Electronic address:
The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we report evidence of enhanced reliance on mitochondrial oxidative phosphorylation (OXPHOS) in oncogene-addicted cancers manifesting acquired resistance to targeted therapies.
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