Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders.

Neurodegenerative disorders are distinguished by the gradual deterioration of the nervous system's structure and function due to oxidative stress, mitochondrial dysfunction, protein misfolding, excitotoxicity, and neuroinflammation. Among these NDs, Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis characterized an increasing dysfunction and loss of neuronal structure leading to neuronal cell death. Although there is currently no drug to totally reverse the effects of NDs, such novel formulations and administration routes are developed for better management and nose-to-brain delivery is one of delivery for treating NDs.

Advances of microneedles in hormone delivery.

The skin is recognized as a potential target for local and systemic drug delivery and hormone. However, the transdermal route of drug administration seems to be limited by substantial barrier properties of the skin. Recently, delivering hormone via the skin by transdermal patches is a big challenge because of the presence of the stratum corneum that prevents the application of hormone via this route.

GAC3D: improving monocular 3D object detection with ground-guide model and adaptive convolution.

Monocular 3D object detection has recently become prevalent in autonomous driving and navigation applications due to its cost-efficiency and easy-to-embed to existent vehicles. The most challenging task in monocular vision is to estimate a reliable object's location cause of the lack of depth information in RGB images. Many methods tackle this ill-posed problem by directly regressing the object's depth or take the depth map as a supplement input to enhance the model's results.

Nanotechnology-based drug delivery for central nervous system disorders.

Drug delivery to central nervous system (CNS) diseases is very challenging since the presence of the innate blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier that impede drug delivery. Among new strategies to overcome these limitations and successfully deliver drugs to the CNS, nanotechnology-based drug delivery platform, offers potential therapeutic approach for the treatment of some common neurological disorders like Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease. This review aimed to highlight advances in research on the development of nano-based therapeutics for their implications in therapy of CNS disorders.

Evaluation of Anti-Hepatocellular-Cancer Properties of β-Sitosterol and β-Sitosterol-Glucoside from Indigofera zollingeriana Miq.

Liver cancer is the most frequent cancer, making it the leading cause of cancer death globally. Traditional medicinal plants with anticancer properties can be used as drugs or dietary adjuvants to existing therapies. This chapter presents a protocol for the preparation of β-sitosterol and β-sitosterol-glucoside from Indigofera zollingeriana Miq (I.

Evaluation of Antimicrobial and Anticancer Activities of Bouea macrophylla Ethanol Extract.

The Bouea macrophylla (B. macrophylla) tree is widely grown throughout South East Asia and has been used as a traditional medicine for the treatment of various illnesses. This chapter presents a protocol for preparation of ethanol extracts of B.

Evaluation of Antidiabetic Properties of Adenosma Bracteosum Bonati Extracts in Mice with Streptozotocin-Induced Diabetes.

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia. Traditional medicinal plants with antidiabetic properties can be used as drugs or dietary adjuvants to existing therapies. This chapter presents the preparation of aqueous and ethanol extracts of Adenosma bracteosum Bonati (A.

A web based methane emissions modelling platform: Models and software development.

This study developed a platform using a modelling and web technology approach to estimate methane emissions from landfills to assess methane emissions across the region. The web technology-based software EnLandFill, which was developed, allows users to log in, interact with landfill databases, and document and extract information regarding landfill emissions. Models that integrate web technology with databases and geographic information systems (GIS) are described.

Methane emission quantification from municipal waste landfills: models and computer software-a case study of Long An Province, Vietnam.

Vietnam has been one of the nations strongly affected by climate change; hence, finding and promoting solutions in order to adapt and proactively respond to climate change have played an extremely significant role. A strategy of developing a low-carbon economy with eco-friendly production and consumption models, limiting the use of fossil fuels, and rising clean as well as renewable energy have been built with the aim to reduce total greenhouse gas (GHG) emissions by roughly 8% by the year 2030 compared to the business-as-usual (BAU) scenario under the Paris Agreement 2015, in particular, focusing on producing a plan to drop considerably methane (CH) emission and recover energy from landfill sites as the waste sector has been the third-highest GHG contributor in Vietnam. This study concentrates on forecasting and evaluating CH, CO, HS, and CHSH emissions for a case study in the Mekong Delta region of Vietnam: in specific, two dumping sites of Thanh Hoa and Kien Tuong according to four different scenarios so that the landfill gas (LFG) emissions are controlled under the local authority orientation of installing a gas collection system and treating captured gases by an LFG flaring approach from 2021 to 2030.

Testing role of green financing on climate change mitigation: Evidences from G7 and E7 countries.

The study estimates the long-run dynamics of a cleaner environment in promoting the gross domestic product of E7 and G7 countries. The recent study intends to estimate the climate change mitigation factor for a cleaner environment with the GDP of E7 countries and G7 countries from 2010 to 2018. For long-run estimation, second-generation panel data techniques including augmented Dickey-Fuller (ADF), Phillip-Peron technique and fully modified ordinary least square (FMOLS) techniques are applied to draw the long-run inference.

Vertical financial disparity, energy prices and emission reduction: Empirical insights from Pakistan.

The economic and environmental aspects of energy production have become important due to the increasing complexity energy sector and envoirnmental pollution, warranting to test the connection between financial imbalances, energy prices and carbon emission. The study aims to test the impact of vertical fiscal imbalances (VFI) on energy prices and carbon emission trends by considering the dual-perspectives of environmental regulation and industrial structure. The empirical outcomes indicated that vertical fiscal imbalances limited the environmental quality of Pakistan.

Organic Positive Materials for Magnesium Batteries: A Review.

Magnesium batteries, like lithium-ion batteries, with higher abundance and similar efficiency, have drawn great interest for large-scale applications such as electric vehicles, grid energy storage and many more. On the other hand, the use of organic electrode materials allows high energy-performance, metal-free, environmentally friendly, versatile, lightweight, and economically efficient magnesium storage devices. In particular, the structural diversity and the simple activity of organic molecules make redox properties, and hence battery efficiency, easy to monitor.

Robust Position Control of an Over-actuated Underwater Vehicle under Model Uncertainties and Ocean Current Effects Using Dynamic Sliding Mode Surface and Optimal Allocation Control.

Underwater vehicles (UVs) are subjected to various environmental disturbances due to ocean currents, propulsion systems, and un-modeled disturbances. In practice, it is very challenging to design a control system to maintain UVs stayed at the desired static position permanently under these conditions. Therefore, in this study, a nonlinear dynamics and robust positioning control of the over-actuated autonomous underwater vehicle (AUV) under the effects of ocean current and model uncertainties are presented.

The novel method to reduce the silica content in lignin recovered from black liquor originating from rice straw.

Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more effectively and selectively. The method is established by monitoring the precipitation behavior as well as the chemical structure of precipitate by single-stage acidification at different pH values of black liquor collected from the alkaline treatment of rice straw.

Combination of data-driven models and interpolation technique to develop of PM10 map for Hanoi, Vietnam.

The degradation of air quality is the most concerned issue of our society due to its harmful impacts on human health, especially in cities with rapid urbanization and population growth like Hanoi, the capital of Vietnam. This study aims at developing a new approach that combines data-driven models and interpolation technique to develop the PM concentration maps from meteorological factors for the central area of Hanoi. Data-driven models that relate the PM concentration with the meteorological factors at the air quality monitoring stations in the study area were developed using the Multiple Linear Regression (MLR) and Artificial Neural Network (ANN) algorithms.

Series of M-MOF-184 (M = Mg, Co, Ni, Zn, Cu, Fe) Metal-Organic Frameworks for Catalysis Cycloaddition of CO.

In light of the chemical exploitation of CO, new reusable materials for efficiently catalyzing the cycloaddition of CO and epoxides under moderate conditions are needed. Herein, a new series of isostructural metal-organic frameworks (MOFs) M(EDOB) [EDOB = 4,4'-(ethyne-1,2-diyl)bis(2-oxidobenzoate), M = Mg, Ni, Co, Zn, Cu, Fe], known as M-MOF-184, analogous to a well-studied MOF-74 structure, were synthesized and fully characterized. The M-MOF-184 (M = Mg, Co, Ni, Zn) frameworks exhibit accessible mesopore channels (24 Å) and high porosity.

Long-term operation of the pilot scale two-stage anaerobic digestion of municipal biowaste in Ho Chi Minh City.

A pilot-scale two-stage anaerobic digestion system, which includes a feed tank (0.4 m), a hydrolysis reactor (1.2 m) followed by a methane fermenter (4.

Model for assessing health damage from air pollution in quarrying area - Case study at Tan Uyen quarry, Ho Chi Minh megapolis, Vietnam.

Vietnam has a great demand for stone exploitation for the development of the country's infrastructure, reaching 181 million m in 2020. Mining activities are always accompanied by environmental pollution, negatively affecting public health. To accurately assess the level of pollution, as well as quantify the effect of air pollution on human health, a number of structures, methods, and models provide tools to assess the benefits of this control for public health and related economic values.

One-step synthesis of 2,5-diformylfuran from monosaccharides by using lanthanum(III) triflate, sulfur, and DMSO.

The combination of lanthanum(iii) triflate, sulfur, and dimethyl sulfoxide prompted a facile, direct preparation of 2,5-diformylfuran from glucose and fructose. The one-step dehydration/oxidation of fructose afforded 2,5-diformylfuran in an excellent yield with high selectivity. The proposed mechanism, large-scale synthesis, and product separation were presented.

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges.

Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects.

Bioaccumulation of trace elements in the hard clam, Meretrix lyrata, reared downstream of a developing megacity, the Saigon-Dongnai River Estuary, Vietnam.

A large number of white hard clam farms are in the estuary shoreline of Saigon-Dongnai Rivers, which flow through Ho Chi Minh City, a megacity, and numerous industrial zones in the basin catchment area. In this study, eleven trace elements (Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Hg, and Pb) in the hard clam Meretrix lyrata and its habitats including surface water, suspended particulate matter, and sediment were evaluated to understand the bioaccumulation of trace metals from the environment into the whole tissues of the hard clam as well as its different organs. The samples were collected monthly in dry, transition, and wet seasons of the southern part of Vietnam from March to September 2016.