Hybridisation of in silico and in vitro bioassays for studying the activation of Nrf2 by natural compounds.

Oxidative stress, characterized by the damaging accumulation of free radicals, is associated with various diseases, including cardiovascular, neurodegenerative, and metabolic disorders. The transcription factor Nrf2 is pivotal in cellular defense against oxidative stress by regulating genes that detoxify free radicals, thus maintaining redox homeostasis and preventing cellular aging. Keap1 plays a regulatory role through its interaction with Nrf2, ensuring Nrf2 degradation under homeostatic conditions and facilitating its stabilization and nuclear translocation during oxidative stress.

Economic evaluation of tenofovir disoproxil fumarate prophylaxis to prevent mother-to-child transmission of Hepatitis B virus infection: evidence from a lower-middle income country.

No cost-effectiveness information of preventive strategies for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) has existed for policy decision making. This study aimed to compare the cost-effectiveness of alternative strategies to prevent MTCT of HBV in Vietnam. Cost-utility analysis using a hybrid decision-tree and Markov model were performed from healthcare system and societal perspectives.

Comparative analysis of the fit quality of monolithic zirconia veneers produced through traditional and digital workflows using silicone replica technique: an in vitro study.

Background: The success of a restoration largely depends on the quality of its fit. This study aimed to investigate the fit quality of monolithic zirconia veneers (MZVs) produced through traditional and digital workflows.

Methods: A typodont maxillary right central incisor was prepared.

Comparative Study on the Hypoglycemic Effects of Different Parts of .

Diabetes mellitus is a chronic metabolic disorder that can cause elevated blood glucose levels due to impaired insulin secretion or resistance. Different parts of have been used widely in traditional medicine to treat many disorders. The present study aims to evaluate the antidiabetic ability of the corm, pseudostem, inflorescence, fruit, peel, and seed of via in vitro experiments by inhibiting α-amylase and α-glucosidase enzymes as well as in vivo models on diabetic alloxan-induced mice.

Application of AVL BOOST modeling to optimize the engine working load and drivetrain transmission ratio of the diesel firefighting pump system.

The drivetrain is an essential component of the diesel firefighting pump system, affecting the engine's operating mode, power, economy, and environment. This study proposes a process to design and optimize the transmission ratio and working load of the diesel firefighting pump system. AVL BOOST software was used to model the 6-cylinder diesel engine and analyze the performance characteristics at its partial loads as parameters for finding the optimal transmission ratio of the drivetrain.

Antibacterial Potential of Ethyl 3,5-Dibromoorsellinate, a Derivative of Diphenyl Ethers from , against Methicillin-Resistant .

is a human pathogen responsible for a variety of diseases, from skin, soft tissue, and lung infections to severe cases such as meningitis, infective endocarditis, and bacteremia. The high level of antibiotic resistance in these pathogens, exemplified by methicillin-resistant (MRSA), necessitates the development of effective antibiotics. Thus, this work introduced the chemical synthesis of ethyl 3,5-dibromoorsellinate, a derivative of ethyl orsellinate from the lichen mycobiont of , and its effectiveness against MRSA was assessed.

Formulation and optimization study of nanodelivery system encapsulating guava wild leaf extract for potential anti-inflammatory properties.

Psidium guajava L. (Myrtaceae) has long been used in folk medicine as a potent therapeutic agent for the treatment of inflammation. Despite its potential, the application of this natural source remains limited because of its instability and poor permeability through biological barriers.

Macrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route.

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer. Paclitaxel (PTX), typically administered intravenously (IV) as chemotherapy, shows promise for triggering immunogenic cell death (ICD) and may serve as a potential immunotherapy. This study introduces an oral PTX delivery method using an enteric-coated gelatin capsule containing capric acid oil and an effervescent agent, optionally with decylamine-conjugated β-glucans (DA-βGlus).

Navigating challenges in Vietnamese enterprises: An examination of the interplay between environmental regulations, organizational innovation, resilience, learning support, and performance.

This study examines the interplay between environmental regulations, organizational innovation, resilience, learning support, and performance in the Vietnamese business context. The paper explores the mutual interaction and influence among these variables. Additionally, it focuses on the indirect effects of organizational innovation and resilience, showing that organizational innovation mediates the relationship between environmental regulations and performance and resilience mediates the relationship between organizational learning support and performance.

Deep eutectic solvent as a green catalyst for the one-pot multicomponent synthesis of 2-substituted benzothiazole derivatives.

The need for diverse essential chemicals and resources has markedly risen alongside the advancement of civilization. Regrettably, many toxic solvents used in chemical laboratories and industrial settings pose significant risks to the health of researchers and intensify environmental pollution. Deep eutectic solvents (DESs), serving as an alternative to ionic liquids, provide superior environmental benefits and have garnered significant interest in chemical research.

Microalgae - bacteria based wastewater treatment systems: Granulation, influence factors and pollutants removal.

Wastewater treatment based on microalgae and bacteria symbiosis is an environmentally friendly, sustainable technology that has attracted attention recently because of its high efficiency in treating pollutants, saving energy, and short-term biomass recovery. Among them, the granular microalgae and bacteria combination emerges with the advantages of rapid gravity settling, good resistance to adverse environmental conditions, outstanding wastewater treatment performance, and easy biomass recovery. This review aims to clarify the microalgal-bacterial granule (MBG) - based process for wastewater treatment.

A length-band fluorescence-based paper analytical device for detecting dipicolinic acid ofloxacin complexation with Cu.

Dipicolinic acid (DPA) is a key biomarker of bacterial spores. In this study, we present a novel distance-based paper analytical device (d-PAD) for the fluorescence sensing of DPA. The detection mechanism relies on the complexation of ofloxacin (OFL) with Cu ions, where Cu quenches the fluorescence of OFL static quenching.

Fostering organizational performance through innovation: The roles of environmental policy instruments, organizational learning supports, and intellectual capital.

This study aimed to examine the key factors that influence entrepreneurial innovation and organizational performance, specifically focusing on the impact of environmental policy instruments, intellectual capital, and organizational learning. In the context of the resource-based view and institutional theory, the authors developed a comprehensive research model to establish hypotheses about the relationships between these factors. Utilizing a survey-based technique with random sampling, this study analyzes the complex relationships between variables by employing structural equation modeling.

Improving properties of chitosan/polyvinyl alcohol films using cashew nut testa extract: potential applications in food packaging.

Cashew nut testa, a by-product of cashew nut processing, is abundant in phenolic compounds and exhibits strong antioxidant properties, making it a potential additive for enhancing the antioxidant properties of biodegradable films used in food packaging. This study explores the fabrication of biodegradable chitosan/polyvinyl alcohol films incorporating varying concentrations of cashew nut testa extract (CNTE; 0, 1, 2 and 3% v/v) and evaluates their physical, structural, mechanical, optical and antioxidant properties. The results demonstrate that increasing extract concentration generally increased the thickness, tensile strength, Young's modulus, thermal stability and antioxidant capacity of the films, while reducing the moisture content, swelling degree, elongation at break, and light transmittance.

HLA Compatibility and Graft Survival Rates Among Related and Unrelated Donors in Renal Transplantation.

Human leukocyte antigen (HLA) compatibility between donors and recipients plays a critical role in graft survival in renal transplantation. This study evaluates the impact of HLA mismatching on graft survival and rejection among renal transplant recipients with related and unrelated donors, considering factors such as age, sex, ABO blood type, and anti-HLA antibodies. We investigated the graft survival rates between related and unrelated donors in a prospective cohort study conducted from 2018 to 2020 at Cho Ray Hospital and People's Hospital 115 in Vietnam, involving 126 related and 82 unrelated donor-recipient pairs.

Enhanced Fenton-Photocatalytic Degradation of Rhodamine B over Cobalt Ferrite Nanoparticles Synthesized by a Polyvinylpyrrolidone-Assisted Grinding Method.

A simple grinding method using polyvinylpyrrolidone (PVP) as a capping agent is introduced to synthesize CoFeO nanoparticles. The effects of calcination temperature (ranging from 450 to 850 °C) on the structural, morphological, physical, and optical properties of the materials are investigated using various techniques, including thermogravimetric analysis/differential scanning calorimetry (TGA/DSC), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), N adsorption isotherm, ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS), and vibrating sample magnetometry (VSM). The presence of PVP significantly suppresses the agglomeration of the materials, resulting in a nanocrystalline size of 18 nm for a sample calcined at 650 °C, which is approximately 38% smaller than that of the sample synthesized without PVP.

Determining risk-adapted starting age and interval for breast cancer screening based on reproductive and hormonal factors.

This study aimed to elucidate the risk of developing breast cancer (BC) by reproductive and hormonal profiles to suggest risk-adapted starting screening ages and to investigate risks after negative mammography results to inform screening intervals in the Korean setting. Participants who performed health examinations between 2002 and 2023 at the National Cancer Center were analyzed. Risk-adapted starting age of screening was defined as the age at which women with various reproductive and hormonal profiles obtained a 10-year cumulative risk level similar to women aged 40 years in the general population.

Copper-Catalyzed Cascade Cyclization of 2-Nitrochalcones with NH-Heterocycles.

We developed a method for allowing cascade cyclization of 2-nitrochalcones with pyrazoles, imidazole, and indazole in the presence of CuI catalyst, DBU base, and THF solvent. The conditions were tolerant of an array of useful functionalities including ester, nitro, cyano, halogen groups. A mechanistic consideration was also provided, as HO was presumably a byproduct.

Synthesis of highly activated polybenzene-grafted carbon nanoparticles for supercapacitors assisted by solution plasma.

The growing demand for electronic storage devices with faster charging rates, higher energy capacities, and longer cycle lives has led to significant advancements in supercapacitor technology. These devices typically utilize high-surface-area carbon-based materials as electrodes, which provide excellent power densities and cycling stability. However, challenges such as inadequate electrolyte interaction, hydrophobicity that impedes ion transport, and high manufacturing costs restrict their effectiveness.

A new microporous organic-inorganic hybrid titanium phosphate for selective acetalization of glycerol.

We developed a novel strategy for synthesizing a highly acidic microporous hybrid titanium phosphate material (H-TiPOx) by incorporating 5-aminosalicylic acid (5-ASA) into the titanium phosphate framework. This new H-TiPOx serves as a Brønsted acid catalyst, exhibiting remarkable total surface acidity of 5.9 mmol g and it efficiently catalyzes the acetalization of abundant biomass derived glycerol to solketal with over 99% selectivity.

Correlation between organic residuals of green synthesized nanoparticles and resistive switching behavior.

In this work, ZnO nanoparticles (NPs) are synthesized using avocado seed extract and annealed at different annealing temperatures from 400 to 800 °C. The morphology of the nanoparticles changes from poly shapes at 400 °C to spherical ones at 800 °C, and particle sizes increase from ∼42 nm to ∼128 nm. The Ag/ZnO@400/FTO memory device exhibits stable resistive switching over 100 cycles and a resistance window of approximately 150.

Investigating Ni nanoparticles on CeO for methane dissociation: a comparative study of theoretical calculations and experimental insights.

CeO supported with Ni nanoparticles has emerged as a promising catalyst for enhancing the efficiency of dry reforming of methane (DRM) reaction. Methane dissociation (CH → CH + H) was reported as one of the rate-determining steps in the DRM reaction. We elucidated the reaction mechanism and explored methods for reducing the activation energy using density functional theory (DFT) calculations, where the activation energy of methane dissociation was determined at multiple Ni cluster sites on CeO.