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Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas.

J Clin Oncol

September 2004

Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medidine, Taipei, Taiwan.

Sung-Hsin Kuo Li-Tzong Chen Kun-Huei Yeh Ming-Shiang Wu Hui-Chen Hsu

Purpose: A high percentage of early-stage, high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori dependent. t(11;18)(q21;q21), a genetic aberration highly predictive of H. pylori-independent status in low-grade gastric MALT lymphoma, is rarely detected in its high-grade counterpart.

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Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas.