CNN-Based Cross-Modality Fusion for Enhanced Breast Cancer Detection Using Mammography and Ultrasound.

Breast cancer is a leading cause of mortality among women in Taiwan and globally. Non-invasive imaging methods, such as mammography and ultrasound, are critical for early detection, yet standalone modalities have limitations in regard to their diagnostic accuracy. This study aims to enhance breast cancer detection through a cross-modality fusion approach combining mammography and ultrasound imaging, using advanced convolutional neural network (CNN) architectures.

Copper(I)-Catalyzed Intramolecular Tandem Acylation/-Arylation under Mild Conditions: Synthesis of Benzofuro[3,2-]quinolin-6(5)-ones and G-Quadruplex-Targeting Analogues.

This paper presents a copper(I)-catalyzed intramolecular tandem acylation/-arylation of methyl 2-[2-(2-bromophenyl)acetamido]benzoates for the synthesis of benzofuro[3,2-]quinolin-6(5)-ones under mild conditions. The combination of CuI, 1,10-phenanthroline, and KCO in DMSO was found to be the optimal reaction condition, producing the target products in high yields (84-99%) at 70 °C for 16 h. The tandem reaction was applicable to substrates bearing halo, electron-withdrawing, and electron-donating groups at their phenyl moieties with a broad substrate scope.

Navigating the obesity paradox in bladder cancer prognosis-insights from the Taiwan National Health Insurance System Database.

Purpose: This study investigates the complex relationship between body mass index (BMI) and bladder cancer outcomes, utilizing Taiwan's national database. Bladder cancer remains a significant health concern, especially in Taiwan, prompting a comprehensive retrospective analysis to explore the impact of obesity on survival outcomes.

Materials And Methods: A meticulous exclusion process, based on Taiwan National Health Insurance System Database, refined the initial dataset of 15,086 bladder cancer patients to 10,352.

Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral Junceella fragilis.

In the present study, an algae-containing octocoral, Junceella fragilis, was subjected to chemical screening. The analysis resulted in the extraction of six polyacetoxybriaranes: a new compound, identified as fragilide Z (1), alongside previously identified analogs, which included 12-epi-fragilide G (2), fragilide P (3), junceellolide D (4), junceellonoid A (5), and juncin ZI (6). The structures of compounds 2-6 were investigated through single-crystal X-ray diffraction analysis, whereas that of 1 was examined through two-dimensional nuclear magnetic resonance analysis.

Hyperbaric Oxygen Therapy Improved Neovascularisation Following Limb Ischaemia-The Role of ROS Mitigation.

Hyperbaric oxygen (HBO) therapy has emerged as a potential treatment, shown to enhance blood flow and angiogenesis. However, specific effects and mechanisms of HBO on limb ischaemia responding to a hypoxic environment remain largely unknown. We aimed to investigate the therapeutic potential of HBO in the treatment of limb ischaemia.

The surface oxidation effect on photocurrent in WSeTe nanosheets.

Surface oxidation effect on photocurrent responsibility was detected in WSeTe nanosheets, and the photocurrent response depends on the light wavelength. It is enhanced at the wavelength of 405 nm, while showing no change at the wavelength of 532 nm and suppressed at the wavelength of 808 nm. The incident photon-to-current efficiency (IPCE) is expected to increase at 405 nm wavelength, remain unchanged at 532 nm wavelength, and decrease at 808 nm wavelength.

Native Defect-Dependent Ultrafast Carrier Dynamics in p-Type Dopable Wide-Bandgap NiO.

NiO is a wide-bandgap p-type metal oxide that has extensive applications in optoelectronics and photocatalysts. Understanding the carrier dynamics in p-type NiO is pivotal for optimizing device performance, yet they remain largely unexplored. In this study, we employed femtosecond transient absorption spectroscopy to delve into the dynamics of photogenerated carriers in NiO films containing distinct prominent native defects: undoped NiO with oxygen vacancies () and O-rich NiO (denoted as NiO) with nickel vacancies ().

Phytochemistry and nutraceutical potential of Ceylon Cinnamomum species native to Sri Lanka.

Cinnamon is a spice that is renowned for its several medicinal and cosmetic benefits. The research study examined the essential oil content, antioxidant, and anti-inflammatory properties of seven species native to Sri Lanka. Cinnamon bark and leaf samples were used to extract essential oils, methanol, and hexane.

Preparation of antibacterial cellulose nanocrystals-graft-poly[2-(tert-butylamino) ethyl methacrylate] nanoparticles and their applications on creating wound dressings with a bacterial shielding property.

Bacterial infections in wounds, especially in patients with chronic conditions like diabetic wounds, pose significant treatment challenges. Addressing the susceptibility to infection is crucial, and the development of functional dressings to prevent bacterial invasion has proven a promising strategy. Cellulose nanocrystals (CNCs), derived from bio-resources and functioning as nanoparticles (NPs), were modified with poly[2-(tert-butylamino) ethyl methacrylate] (PTA) through atom transfer radical polymerization (ATRP) to create CNCs-graft-PTA NPs (CNPs).

Serial changes in metabolic dysfunction-associated steatotic liver disease after sleeve gastrectomy and their associations with abdominal adiposity: a prospective cohort study.

Background: Little is known about the associations between changes in hepatic steatosis and changes in abdominal adiposity after metabolic bariatric surgery.

Objectives: To evaluate the serial changes in hepatic steatosis and abdominal adiposity following sleeve gastrectomy (SG).

Setting: University hospital, Taiwan.

The factors associated with clozapine polypharmacy for schizophrenia patients discharged from a large public psychiatric hospital in Taiwan, 2006-2021.

Clozapine treatment continues to be recognized as the gold standard for managing treatment-resistant schizophrenia. Combining clozapine with other antipsychotics (i.e.

Physics Informed Neural Networks for Estimation of Tissue Properties from Multi-echo Configuration State MRI.

This work investigates the use of configuration state imaging together with deep neural networks to develop quantitative MRI techniques for deployment in an interventional setting. A physics modeling technique for inhomogeneous fields and heterogeneous tissues is presented and used to evaluate the theoretical capability of neural networks to estimate parameter maps from configuration state signal data. All tested normalization strategies achieved similar performance in estimating and .

Description of a new uniformly brown estuarine moray eel (Anguilliformes, Muraenidae) from the Central Indo-Pacific Ocean.

A new estuarine moray eel, , is described based on 14 specimens from Japan, Taiwan, the Philippines, southern Indonesia, and Fiji. It is a small-bodied, slender, uniformly dark-brown moray separated from congeners within the species complex. The new species can be distinguished from congeners by the anteriorly positioned small eyes (5.

, a new beardfish from the western Pacific (Teleostei, Polymixiiformes, Polymixiidae).

A new species of beardfish, genus , is described based on three specimens collected in Taiwanese waters and off the Chesterfield Islands of New Caledonia. It can be distinguished from its congeners by the following characters: dorsal-fin rays IV-V, 35-37; gill rakers on outer face of first gill arch 3+1+6=10; scales row between dorsal-fin origin and lateral line vertically 6-8 (S1) and posteriorly 12-14 (S2); pyloric caeca 40; snout rounded, with its surface rough and gelatinous, its tip evidently protrude anterior margin of premaxilla; ctenii on body scales arranged in a wedge-shape, forming three rows; 4 anal-fin spine long, 1.0%-1.

Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells.

The Jun dimerization protein (Jdp2) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role of Jdp2 in cellular differentiation and pluripotency in the cerebellum, and the effect of the antioxidation reaction on cell plasticity, remain unknown. N-acetyl-L-cysteine (NAC) induced the early commitment of the differentiation of granule cell precursors (GCPs) to neurons, especially Purkinje cells, via the γ-aminobutyric acid type A receptor α6 subunit (Gabra6) axis; moreover, Jdp2 depletion enhanced this differentiation program of GCPs.

Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice.

Background: Hispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked one of the top ten leading causes of death worldwide. Little is known about the effects of hispolon on delaying AD progression.

A 11B-NMR Method for the In Situ Monitoring of the Formation of Dynamic Covalent Boronate Esters in Dendrimers.

The in situ monitoring of dynamic covalent macromolecular boronate esters represents a difficult task. In this report, we present an in situ method using fluoride coordination and B NMR spectroscopy to determine the amount of boronate esters in a mixture of boronic acids and cis-diols. With fluoride coordination, the boronic acid and boronate esters afforded trifluoroborate and fluoroboronate esters, giving identical resonances at 3 and 9 ppm in the B NMR spectra.

Semiconductor Nanomaterials for Optoelectronic Applications.

Nanotechnology has been comprehensively investigated for more than 30 years [...

The Effectiveness of COVID-19 Vaccination on Post-Acute Sequelae of SARS-CoV-2 Infection Among Geriatric Patients.

This study aims to evaluate the effectiveness of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing the post-acute sequelae of SARS-CoV-2 infection (PASC), commonly known as long COVID, and reducing all-cause mortality among older patients. A retrospective cohort study was conducted using the TriNetX database. The study cohort consisted of older patients (age ≥ 65 years) with their first COVID-19 illness between January 1, 2022, and May 31, 2024.

Two-Dimensional Transition Metal Dichalcogenides (2D TMDs) Coupled With Zero-Dimensional Nanomaterials (0D NMs) for Advanced Photodetection.

The integration of 2D transition metal dichalcogenides (TMDs) with other materials presents a promising approach to overcome inherent limitations and enable the development of novel functionalities. In particular, 0D nanomaterials (0D NMs) offer notable advantages for photodetection, including broadband light absorption, size-dependent optoelectronic properties, high quantum efficiency, and good compatibility. Herein, the integration of 0D NMs with 2D TMDs to develop high-performance photodetectors is reviewed.