A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis.

Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that is notably associated with a high risk of lymph node metastasis, a major cause of cancer mortality. Current therapeutic options remain limited to surgery supplemented by radio- or chemotherapy; however, these interventions often result in high-grade toxicities. Distant metastasis significantly contributed to the poor prognosis and decreased survival rates.

Chain-mediated effect of physical activity between Chinese language-based L2 motivational self-system and intended effort.

The L2 Motivational Self System (L2MSS) determines an individual's motivation in second language learning and influences the learning experience and intended effort. Although physical activity (PA) has been shown to enhance academic efficacy, the role of PA in whether it promotes second language learning efficacy has not been elucidated. Therefore, the present study examined PA as a mediator and explored its ameliorative effects in L2MSS.

Chromosome-scale genome assembly of Korean goosegrass (Eleusine indica).

Goosegrass, belonging to the genus Eleusine within the Chloridoideae subfamily, is often one of the problematic weeds with strong invasiveness, competing with crops for essential survival resources. Although a chromosome-level genome assembly of E. indica from China was published last year, the present research focuses on a population of E.

GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment.

The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis.

Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb.

Rhabdomyolysis or Crush syndrome-related AKI (RM/CS-AKI) has high mortality, and there is no effective early on-site treatment method. The critical pathogenic factor of RM/CS-AKI is the excessive free myoglobin (Mb) in blood circulation. Here, based on the concept of creating a "mobile barrier", we develop an anti-Mb rabbit monoclonal antibody (RabMAb) with high specificity, affinity, stability, and broad species reactivity.

Standard operating procedure combined with comprehensive quality control system for multiple LC-MS platforms urinary proteomics.

Urinary proteomics is emerging as a potent tool for detecting sensitive and non-invasive biomarkers. At present, the comparability of urinary proteomics data across diverse liquid chromatography-mass spectrometry (LC-MS) platforms remains an area that requires investigation. In this study, we conduct a comprehensive evaluation of urinary proteome across multiple LC-MS platforms.

Cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional study.

Research suggests that folic acid contributes to improving cognitive function. However, there is a lack of systematic research on the association of dietary intake of folate and serum, and red blood cell (RBC) folate levels with global cognitive impairment (CoI) in the elderly population. Importantly, excessive supplementation with folate among American adults at high risk of cardiovascular disease (CVD) may have harmful effects.

Recovery of nearly 3,000 archaeal genomes from 152 terrestrial geothermal spring metagenomes.

Terrestrial geothermal springs, reminiscent of early Earth conditions, host diverse and abundant populations of Archaea. In this study, we reconstructed 2,949 metagenome-assembled genomes (MAGs) from 152 metagenomes collected over six years from 48 geothermal springs in Tengchong, China. Among these MAGs, 1,431 (49%) were classified as high-quality, while 1,518 (51%) were considered as medium-quality.

An improved sparrow search algorithm with multi-strategy integration.

Addressing the shortcomings of the Sparrow Search Algorithm (SSA), such as low accuracy of convergence and tendency of falling into local optimum, a Multi-strategy Integrated Sparrow Search Algorithm (MISSA) is proposed. In this method, by improving the black-winged kite algorithm and applying it to the producer's position update formula, an improved search strategy (ISS) is firstly proposed to enhance search ability. Secondly, a new strategy inspired by the Coot algorithm, called the group follow strategy (GFS), is proposed to improve the ability to jump out of the local optimum.

Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2- breast cancer.

Endocrine therapy with CDK4/6 inhibitors is standard for estrogen receptor-positive, HER2-negative metastatic breast cancer (ER+/HER2- MBC), yet clinical resistance develops. Previously, we demonstrated that low doses of palbociclib activate autophagy, reversing initial G1 cell cycle arrest, while high concentrations induce off-target senescence. The autophagy inhibitor hydroxychloroquine (HCQ) induced on-target senescence at lower palbociclib doses.

Inverse design of promising electrocatalysts for CO reduction via generative models and bird swarm algorithm.

Directly generating material structures with optimal properties is a long-standing goal in material design. Traditional generative models often struggle to efficiently explore the global chemical space, limiting their utility to localized space. Here, we present a framework named Material Generation with Efficient Global Chemical Space Search (MAGECS) that addresses this challenge by integrating the bird swarm algorithm and supervised graph neural networks, enabling effective navigation of generative models in the immense chemical space towards materials with target properties.

p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment.

Prostate cancer is a heterogeneous disease with a slow progression and a highly variable clinical outcome. The tumor suppressor genes PTEN and TP53 are frequently mutated in prostate cancer and are predictive of early metastatic dissemination and unfavorable patient outcomes. The progression of solid tumors to metastasis is often associated with increased cell plasticity, but the complex events underlying TP53-loss-induced disease aggressiveness remain incompletely understood.

Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair.

Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing, and the abnormal plasticity of SCs would jeopardize the bone regeneration. However, how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood. Here, by employing single-cell transcriptional profiling combined with lineage-specific tracing models, we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury.

Impacts of irrigation expansion on moist-heat stress based on IRRMIP results.

Irrigation rapidly expanded during the 20 century, affecting climate via water, energy, and biogeochemical changes. Previous assessments of these effects predominantly relied on a single Earth System Model, and therefore suffered from structural model uncertainties. Here we quantify the impacts of historical irrigation expansion on climate by analysing simulation results from six Earth system models participating in the Irrigation Model Intercomparison Project (IRRMIP).

Temperature seasonality regulates organic carbon burial in lake.

Organic carbon burial (OCB) in lakes, a critical component of the global carbon cycle, surpasses that in oceans, yet its response to global warming and associated feedbacks remains poorly understood. Using a well-dated biomarker sequence from the southern Tibetan Plateau and a comprehensive analysis of Holocene total organic carbon variations in lakes across the region, here we demonstrate that lake OCB significantly declined throughout the Holocene, closely linked to changes in temperature seasonality. Process-based land surface model simulations clarified the key impact of temperature seasonality on OCB in lakes: increased seasonality in the early Holocene saw warmer summers enhancing ecosystem productivity and organic matter deposition, while cooler winters improved organic matter preservation.

A principle-based framework to determine countries' fair warming contributions to the Paris Agreement.

Equity is a cornerstone of global climate policy, yet differing perspectives mean that international agreement on how to allocate mitigation efforts remains elusive. A rich literature informs this question, but a gap remains in approaches that appropriately consider non-CO emissions and their warming contributions. In this study, we address this gap and define a global warming budget applicable to all anthropogenic greenhouse gases that is allocated to countries based on principles drawn from international treaties and environmental law.

Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis.

The death of osteoblasts induced by glucocorticoid (GC)-mediated oxidative stress plays a crucial role in the development of steroid-induced osteonecrosis of the femoral head (SIONFH). Improving bone formation driven by osteoblasts has shown promising outcomes in the prognosis of SIONFH. Isovitexin has demonstrated antioxidant properties, but its therapeutic effects on GC-induced oxidative stress and SIONFH remain unexplored.

Long-term reconstructed vegetation index dataset in China from fused MODIS and Landsat data.

The vegetation index is a key satellite-based variable used to monitor global vegetation distribution and growth. However, existing vegetation index datasets face limitations in achieving both high spatial and temporal resolution, restricting their application potential. This study revised a machine learning spatiotemporal fusion model (InENVI) to produce a high-resolution NDVI dataset with 8-day temporal and 30 m spatial resolution, covering China from 2001 to 2020.

Single soliton microcomb combined with optical phased array for parallel FMCW LiDAR.

The frequency-modulated continuous-wave (FMCW) technology combined with optical phased array (OPA) is promising for the all-solid-state light detection and ranging (LiDAR). We propose and experimentally demonstrate a silicon integrated OPA combined with an optical frequency microcomb for parallel LiDAR system. For realizing the parallel wavelengths emission consistent with Rayleigh criterion, the wide waveguide beyond single mode region combined with the bound state in the continuum (BIC) effect is harnessed to obtain an ultra-long optical grating antenna array.

Crucial role of subsurface ocean variability in tropical cyclone genesis.

The upper ocean provides thermal energy to tropical cyclones. However, the impacts of the subsurface ocean on tropical cyclogenesis have been largely overlooked. Here, we show that the subsurface variabilities associated with the variation in the 26 °C isothermal depth have pronounced impacts on tropical cyclogenesis over global oceans.

Circulating Free RNA as a Therapeutic Evaluation in Diffuse Large B-cell Lymphoma: A Case Series from the Indonesian Cancer Center.

Cancer is still the leading cause of death worldwide. Despite advances in diagnosis, management with the rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R-CHOP) chemotherapy regimen, and careful clinical and radiologic evaluation, diffuse large B-cell lymphoma (DLBCL) still carries high recurrence in clinical practice. This case series aims to assess the potential of circulating free RNA as a biomarker for evaluating therapeutic responses in DLBCL.

Outcome Prediction in Infectious Disease.

Sepsis is a critical, life-threatening condition that demands precise prediction to mitigate adverse outcomes. The heterogeneity of sepsis leads to variable prognoses, making early and accurate identification increasingly difficult. Despite ongoing advancements, no single gold standard has emerged for sepsis prediction.

The Role of Inflammatory Parameters and Antibody Seroconversion on COVID-19 Outcomes in Patients with Central Obesity.

Background: Central obesity increases the risk of developing poor outcomes of COVID-19. The pro-inflammatory state and antibody dysfunction are thought to contribute to poor outcomes; however, the evidence is unclear.

Methods: This is a cohort study among COVID-19 patients with central obesity in Dr.

The First Multiomics Association Study of Trace Element and Mineral Concentration and RNA Sequencing Profiles in Human Cancers.

Integration of various types of omics data is an important trend in contemporary molecular oncology. In this regard, high-throughput analysis of trace and essential elements in cancer biosamples is an emerging field that has not yet been sufficiently addressed. For the first time, we simultaneously obtained gene expression profiles (RNA sequencing) and essential and trace element profiles (inductively coupled plasma mass spectrometry) for a set of human cancer samples.

Effect of 8-Oxo-1,-Ethenoadenine Derivatives on the Activity of RNA Polymerases from SARS-CoV-2 and .

Bacterial and viral RNA polymerases are promising targets for the development of new transcription inhibitors. One of the potential blockers of RNA synthesis is 7,8-dihydro-8-oxo-1,-ethenoadenine (oxo-εA), a synthetic compound that combines two adenine modifications: 8-oxoadenine and 1,-ethenoadenine. In this study, we synthesized oxo-εA triphosphate (oxo-εATP) and showed that it could be incorporated by the RNA-dependent RNA polymerase of SARS-CoV-2 into synthesized RNA opposite template residues A and G in the presence of Mn ions.