Proportional impact prediction model of coating material on nitrate leaching of slow-release Urea Super Granules (USG) using machine learning and RSM technique.

An accurate assessment of nitrate leaching is important for efficient fertiliser utilisation and groundwater pollution reduction. However, past studies could not efficiently model nitrate leaching due to utilisation of conventional algorithms. To address the issue, the current research employed advanced machine learning algorithms, viz.

Physiological functions, pharmacological aspects and nutritional importance of green tomato- a future food.

Green tomatoes contain significant levels of steroidal glycoalkoids (SGA) such as α-tomatine and green pigment chlorophyll. Tomatine is an admixture of two glycoalkoids; alpha tomatine and dehydrotomatine reported various health beneficial biological activities. Moreover, a hydrolyzed product of tomatine also contributes to age-related atrophy, and muscle weakness and helps the elderly recover from illness and injuries related to age.

A Study of Maternal and Umbilical Cord Blood Lead Levels in Pregnant Women.

Lead is a highly toxic element which can cross the placental barrier and enter the fetus during pregnancy. Parental lead exposure has adverse effect on infant as well as on maternal health. As part of our program to investigate the lead poisoning in human population we investigated the maternal blood lead levels (MBLL) and umbilical cord blood lead (UBLL) levels in 200 pregnant women and collected their socio-demographic details.

Impact of climate change induced future rainfall variation on dynamics of arid-humid zone transition in the western province of India.

The transition of the Earth's climate from one zone to another is one of the major causes behind biodiversity loss, rural-urban migration, and increasing food crises. The rising rate of arid-humid zone transition due to climate change has been substantially visible in the last few decades. However, the precise quantification of the climate change-induced rainfall variation on the climate zone transition still remained a challenge.

Chemical Characterization, Evaluation, and Molecular Docking Analysis of Antiproliferative Compounds Isolated from the Bark of Miq.

Aims: The present study aimed to isolate and characterize chemical compounds from Anthocephalus cadamba Miq. bark and evaluate their anticancer activity by in silico, molecular docking, and in vitro studies.

Background: Anthocephalus cadamba is a traditionally used Indian medicinal plant.

Antiproliferative Activity of L. Extract Against Human Cervical Cancer Cells: In Vitro and In Silico Analysis.

Background: Cervical cancer is the second leading cause of cancer in women, which necessitates safe and potential therapeutic agents.

Objective: This study was designed to investigate the antiproliferative effect of ethanolic extract of Cissus quadrangularis L. (CQ) against human cervical adenocarcinoma HeLa cell line and in silico analysis of selected active agents against apoptosis executioner enzyme caspase-3.

Case of Lead Poisoning Associated with Herbal Health Supplements.

Background: Lead poisoning is a chronic health condition arising from prolonged ingestion and exposure to lead above permissible limits. Although reported globally, developing countries like India and neighboring countries are amongst the most affected by lead.

Objectives: The aim of the present study was to evaluate lead poisoning associated with herbal health supplements in a suspected case.

Blood Lead Levels in Children Living Near an Informal Lead Battery Recycling Workshop in Patna, Bihar.

Background: Lead can cause significant biological and neurologic damage, even at small concentrations, and young children are at higher risk. Informal recycling of lead batteries and lead-based workshops/industries have increased the burden of lead toxicity in developing countries, including India. Many informal recycling lead battery workshops have been established by the local people of Patna, Bihar as self-employment opportunities.

Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation.

Piperine (1-piperoylpeperdine), a nitrogenous pungent substance, is present in the fruits of black pepper ( Linn.) and long pepper ( Linn.).

HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves.

In this study, we have aimed to analyze the phytochemical composition of this plant and the concentration of strychnine and brucine. The identification of bioactive compounds was done by GC-MS with NIST Library. Strychnine and Brucine were quantified using HPLC.

Piperine Triggers Apoptosis of Human Oral Squamous Carcinoma Through Cell Cycle Arrest and Mitochondrial Oxidative Stress.

Piperine is a nitrogenous pungent substance exhibiting multifunctional pharmacological properties. However, the mechanism underlying its anticancer potential is not well elucidated in human oral squamous carcinoma (KB) cell line. The anticancer potential of piperine was evaluated through potent biomarkers viz.

Anticarcinogenic and antimutagenic activity of Alstonia scholaris on the albino mice bone marrow cells and peripheral human lymphocyte culture against methyl methane sulfonate induced genotoxicity.

Background: The use of medicinal plants in modern medicine for the prevention and treatment of cancer is an important aspect. For this reason, it is important to identify antitumor promoting agents present in medicinal plants commonly used by the human population.

Materials And Methods: We used in vivo and in vitro methods using chromosomal aberrations (CAs), sister chromatid exchange (SCE) and replication index (RI) as markers, exposed by methyl methanesulfonate (MMS) as well as alcoholic extract of Alstonia scholaris in five increasing concentrations (200, 250, 300, 350 and 400 mg/kg body weight for in vivo and 150, 200, 250 and 300 μg/ml of culture) and of three different durations of 24, 48 and 72 h in the presence as well absence of S9 mix.

Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest.

A natural predominant flavanone naringenin, especially abundant in citrus fruits, has a wide range of pharmacological activities. The search for antiproliferative agents that reduce skin carcinoma is a task of great importance. The objective of this study was to analyze the anti-proliferative and apoptotic mechanism of naringenin using MTT assay, DNA fragmentation, nuclear condensation, change in mitochondrial membrane potential, cell cycle kinetics and caspase-3 as biomarkers and to investigate the ability to induce reactive oxygen species (ROS) initiating apoptotic cascade in human epidermoid carcinoma A431 cells.