13 results match your criteria: "National Minami Hanamaki Hospital[Affiliation]"

Structural abnormalities found in probands with schizophrenia have been reported to occur to some degree in their unaffected relatives. However, there has yet to be a study that has focused on brain changes of parents of schizophrenics who are not the presumed obligate carriers. Using MRI, the authors studied the ventricle-brain ratio (VBR) of 9 pairs of parents of schizophrenics and 18 age- and sex-matched healthy controls.

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Although the precise etiology of schizophrenia remains unknown, the development of schizophrenia has been associated with a history of obstetric complication (OC). Furthermore, some studies show structural and functional brain abnormalities in the unaffected siblings of schizophrenics. In this study the perinatal histories of 18 unaffected siblings of schizophrenics and 15 unrelated healthy controls, as detailed in their mothers' Maternal and Child Health Handbook records, were retrospectively analyzed.

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Significance of human striatal D-neurons: implications in neuropsychiatric functions.

Prog Neuropsychopharmacol Biol Psychiatry

May 2004

Clinical Research Institute, National Minami Hanamaki Hospital, 500 Suwa, Hanamaki, Iwate, 025-0033, Japan.

The human striatum, especially its ventral part, the nucleus accumbens (Acc), contains numerous nonmonoaminergic aromatic L-amino acid decarboxylase (AADC) [=dopa decarboxylase (DDC)] neurons (D-neurons). AADC is the second-step synthesizing enzyme for monoamines and is also the rate-limiting enzyme of phenylethylamine (PEA) synthesis. D-neurons may participate in the manifestation of efficacy of pharmacotherapy for Parkinson's disease by taking up monoamine precursors including L-dopa or droxidopa (L-threo-DOPS) and by converting them to dopamine or noradrenaline, respectively.

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Objective: This study was carried out to evaluate the influence of CYP2D6 polymorphism and smoking on the plasma clearance of haloperidol (HAL) levels, accounting for the antipsychotic dose, body weight, and coadministration of other drugs.

Methods: Subjects were 110 Japanese patients (66 male, 44 female) diagnosed with schizophrenia, dementia, or mood disorder and treated orally with HAL. Venous blood was obtained from each patient to determine the HAL concentration/dose (C/D) ratio (plasma concentration of HAL divided by the daily dose of HAL per body weight) and for CYP2D6 genotyping.

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[Effect of factors on plasma haloperidol concentration/dose ratio].

Nihon Shinkei Seishin Yakurigaku Zasshi

August 2003

Clinical Research Institute, National Minami Hanamaki Hospital, Kanagawa Prefectural Center for Psychiatry, 2-5-1 Serigaya, Kohnan, Yokohama, 233-0006 Japan.

It has been known that the serum concentration of antipsychotics is varied according to individual case. There are several factors that may affect the plasma levels of antipsychotics; e.g.

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The human striatum, especially its ventral part, the nucleus accumbens, contains numerous neurons immunoreactive for aromatic L-amino acid decarboxylase (AADC, the second-step monoamine synthesizing enzyme, =DDC: dopa decarboxylase), but not for tyrosine hydroxylase (TH, the first-step catecholamine synthesizing enzyme) or tryptophan hydroxylase (TPH, the first-step serotonin synthesizing enzyme) (Neurosci Lett 232 (1997) 111-114). These AADC (+)/TH (-)/TPH (-) neurons are named as D-neurons (Jaeger CB, Ruggiero DA, Albert VR, Joh TH, Reis DJ. Immunocytochemical localization of aromatic-L-amino acid decarboxylase.

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Effects of age and the CYP2D6*10 allele on the plasma haloperidol concentration/dose ratio.

Prog Neuropsychopharmacol Biol Psychiatry

May 2003

Clinical Research Institute, National Minami Hanamaki Hospital, 500 Suwa, Hanamaki, Iwate 025-0033, Japan.

The authors studied the effect of aging and the CYP2D6*10 polymorphism on the plasma haloperidol (HAL) concentration after chronic administration of HAL. Subjects were 110 Japanese patients (66 male) treated orally with HAL. Venous blood was obtained from each patient for determination of the HAL concentration/dose (C/D) ratio (the plasma concentration of HAL divided by the daily dose of HAL per kilogram body weight) and for CYP2D6 genotyping.

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Objective: The purpose of the present study was to investigate whether plasma fluvoxamine (FV) concentration is associated with CYP2D6*10 allele polymorphisms.

Methods: Subjects were 46 Japanese patients (21 males) carrying neither *3, *4 nor *5 alleles and treated orally using FV. Venous blood was obtained from each patient for determination of FV concentration/dose (C/D) ratio (plasma concentration of FV divided by daily dose of FV per body weight) and CYP2D6 genotyping.

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It has recently been reported that the human corpus striatum, especially its ventral part, named as the nucleus accumbens, contains numerous non-monoaminergic aromatic L-amino acid decarboxylase (AADC; the second-step monoamine synthesizing enzyme) neurons (D-neurons). D-neurons are the neurons immunoreactive for AADC but not immunoreactive for dopamine or serotonin. They lack the first-step monoamine synthesizing enzymes, tyrosine hydroxylase and tryptophan hydroxylase.

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[Human striatal D-neurons and their significance].

Nihon Shinkei Seishin Yakurigaku Zasshi

August 2002

Clinical Research Institute, National Minami Hanamaki Hospital, 500, Suwa, Hanamaki, 025-0033 Japan.

It has recently been reported that the human striatum, especially its ventral part, the nucleus accumbens, contains numerous neurons immunoreactive for aromatic L-amino acid decarboxylase (AADC; the second-step monoamine synthesizing enzyme), but not for tyrosine hydroxylase (TH; the first-step catecholamine synthesizing enzyme) or tryptophan hydroxylase (TPH; the first-step serotonin synthesizing enzyme). These AADC (+)/TH(-)/TPH(-) neurons are named D-neurons. AADC is also the rate-limiting synthesizing enzyme of phenylethylamine (PEA).

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[Triplet repeat disease from the aspect of psychiatric disease].

Nihon Shinkei Seishin Yakurigaku Zasshi

November 2000

Clinical Research Institute, National Minami Hanamaki Hospital, 500 Suwa, Hanamaki 025-0033, Japan.

Since 1991, about 20 triplet repeat expansion disorders have been reported. They are clinically characterized by anticipation, worsening severity or earlier age at the onset with each succeeding generation, and imprinting, a process whereby specific genes are differentially, marked during parental gametogenesis, resulting in their differential expression. The anticipation in psychoses was pointed out in the 19th century, but it was ignored because no one knew the mechanism at that time.

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Anticipation, imprinting, trinucleotide repeat expansions and psychoses.

Prog Neuropsychopharmacol Biol Psychiatry

January 2001

Clinical Research Institute, National Minami Hanamaki Hospital, Iwate, Japan.

1. Since 1991, approximately 20 trinucleotide repeat expansion type neurodegenerative disorders have been reported. They are clinically characterized by anticipation, i.

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