Myoclonus: An Electrophysiological Diagnosis.

Background: Many different movement disorders have similar "jerk-like" phenomenology and can be misconstrued as myoclonus. Different types of myoclonus also share similar phenomenological characteristics that can be difficult to distinguish solely based on clinical exam. However, they have distinctive physiologic characteristics that can help refine categorization of jerk-like movements.

Applications of single-cell sequencing for the field of otolaryngology: A contemporary review.

Objectives: Single-cell RNA sequencing (scRNA-Seq) is a new technique used to interrogate the transcriptome of individual cells within native tissues that have already resulted in key discoveries in auditory basic science research. Rapid advances in scRNA-Seq make it likely that it will soon be translated into clinical medicine. The goal of this review is to inspire the use of scRNA-Seq in otolaryngology by giving examples of how it can be applied to patient samples and how this information can be used clinically.

Preconception leptin levels and pregnancy outcomes: A prospective cohort study.

Objective: Obesity has become a major, worldwide public health issue and is associated with a greater risk of adverse pregnancy outcomes. Leptin, a hormone produced by adipocytes, is elevated in individuals with obesity and may mediate the association between obesity and pregnancy outcomes. Though leptin levels during pregnancy have been associated with pregnancy outcomes, less is understood regarding preconception levels.

Gender as a Risk Factor for Functional Movement Disorders: The Role of Sexual Abuse.

Background: The prevalence of functional movement disorders is 2 to 3 times higher in women than in men. Trauma and adverse life events are important risk factors for developing functional movement disorders. On a population level, rates of sexual abuse against women are higher when compared with the rates against men.

First Clinicogenetic Description of Parkinson's Disease Related to Mutation S107L.

Background: Mutations in the glucocerebrosidase gene () are a common genetic risk factor for Parkinson's disease (PD). Mutations in the N-terminus part of are less commonly found in association with PD than those in the C-terminus. Phenotypic characterization of -related PD has been challenging, in part attributed to differential impact of distinct mutations.

Sensory Tricks for Cervical Levodopa-induced Dyskinesia in Patients with Parkinson's Disease.

Choreiform or dystonic movement in the craniocervical region can occur as levodopa-induced dyskinesia (LID). "Sensory tricks" are various alleviating maneuvers for the relief of abnormal postures in patients who have idiopathic focal dystonia, particularly those who have cervical dystonia. The authors report on three men with Parkinson's disease who had been receiving levodopa for more than 3 years and presented with involuntary neck movements during the drug period.

Genetics and genomic medicine in Ecuador.

Genetics and genomic medicine in Ecuador. [Image: see text]

The "Whack-a-Mole" Sign in Functional Movement Disorders.

Making the diagnosis of functional movement disorders can be challenging. Identifying positive physical signs and diagnostic maneuvers is critical to this process. Distractibility, entrainability, and variability are examples of classic physical findings in these patients.

Do Parkinson's Disease Patients Have Deficits in Sequential Sampling Tasks?

The aim of this study was to assess the neuropsychological behavior of Parkinson's disease (PD) patients with addictive behaviors. Characteristically, these patients have younger onset of PD, higher novelty-seeking personality traits, jump to conclusions, and often make irrational choices. We assessed whether PD patients with and without addictive behaviors have deficits in a sequential sampling task, often called the secretary problem.

Clinico-Pathological Correlation in Progressive Ataxia and Palatal Tremor: A Novel Tauopathy.

Palatal tremor (PT) is an uncommon movement disorder that has been subdivided into essential and symptomatic forms. A distinct subgroup of the symptomatic form presents with progressive ataxia and PT. The histopathology of progressive ataxia and PT has not been previously determined.