1,427 results match your criteria: "National Institute of neurology[Affiliation]"

Relative cerebral blood volume as response predictor in the treatment of recurrent glioblastoma with anti-angiogenic therapy.

Clin Neurol Neurosurg

October 2023

The American British Cowdray (ABC) Medical Center, Mexico City, Mexico; Department of Neuro-Oncology, National Institute of Neurology and Neurosurgery, Mexico; Emergency Department, National Institute of Neurology and Neurosurgery, Mexico. Electronic address:

Background: Glioblastoma is one of the most common brain tumors in adult populations, usually carrying a poor prognosis. While several studies have researched the impact of anti-angiogenic therapies, especially anti-VEFG treatments in glioblastoma, few have attempted to assess its progress using imaging studies.

Purpose: We attempted to analyze whether relative cerebral blood volume (rCBV) from dynamic susceptibility-weighted contrast-enhanced MRI (DSC-MRI) could predict response in patients with glioblastoma undergoing Bevacizumab (BVZ) treatment.

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Background: A mitochondrial polygenic score (MGS) is composed of genes related to mitochondrial function and found to be associated with Parkinson's disease (PD) risk.

Objective: To investigate the impact of the MGS and lifestyle/environment on age at onset (AAO) in LRRK2 p.Gly2019Ser parkinsonism (LRRK2-PD) and idiopathic PD (iPD).

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Spontaneous intracranial hemorrhage associated with an intracranial meningioma is rare, with a reported incidence of below 2.4% of all meningiomas. Such cases are described with a cause subdural with intratumoral hemorrhage, which is a challenge for patients and healthcare professionals because it can occur spontaneously without other pathological antecedents.

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: Drug of Abuse and Therapeutic Agent, Two Sides of the Same Coin.

Rev Invest Clin

July 2023

Department of Pharmacobiology, Center for Research and Advanced Studies (Cinvestav), National Polytechnic Institute, Mexico City, Mexico.

The consumption of plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating, and spiritual) due to its psychoactive effects, can be traced back to ancient times. is the most used illicit drug worldwide; however, its legal status is changing rapidly. regulation will allow a better understanding of its effects as a misused drug, including new challenges, such as the availability of highly potent .

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Background: Clinically Isolated Syndrome (CIS) is the first clinical episode suggestive of Clinical Definite Multiple Sclerosis (CDMS). There are no reports on possible predictors of conversion to CDMS in Mexican mestizo patients.

Aim Of The Study: To investigate immunological markers, clinical and paraclinical findings, and the presence of herpesvirus DNA to predict the transition from CIS to CDMS in Mexican patients.

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Background: Neuropsychiatric symptoms (NPSs) are common in neurodegenerative diseases; however, little is known about the prevalence of NPSs in Hispanic populations.

Methods: Using data from community-dwelling participants age 65 years and older enrolled in the 10/66 study (N = 11,768), we aimed to estimate the prevalence of NPSs in Hispanic populations with dementia, parkinsonism, and parkinsonism-dementia (PDD) relative to healthy aging. The Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPSs.

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Background: The middle cerebral artery (MCA) is a common site of cerebral aneurysms and 82.6% occur at the bifurcation. When surgery is selected as a therapeutic option, it intends to clip the neck completely because if some remnant occurs, there exists the possibility of regrowth and bleeding in the short- or long-term.

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Background: Glioblastoma (GB) is the most common and aggressive malignant brain tumor in adults. Extracranial metastases are very rare, been described in the lungs, soft tissue, or the intraspinal space.

Case Description: Through a PubMed-based bibliographic search, the authors reviewed the cases reported in the literature to date, emphasizing the epidemiology and pathophysiology of this rare condition.

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Background: Inflammatory pseudotumors are rare, and those attributed to immunoglobulin G4 (IgG4) diseases are even less frequently encountered. Here, we reviewed 41 cases from the literature of spinal inflammatory pseudotumors due to IgG4 and have added our single new case.

Case Presentation: A 25-year-old male presented with progressive back pain, bilateral paraparesis, and sphincter dysfunction.

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Background and objective Invasive prolactinoma accounts for 1-5% of all prolactinomas. Its mass and compromise of the diencephalon and frontal and temporal lobes may result in a range of neuropsychiatric symptoms that are often missed during initial evaluations. Cabergoline is a dopaminergic agonist used as the first-line treatment for these patients; however, its effect on neuropsychiatric symptoms in this particular setting remains unexplored.

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Toward responsible clinical n-of-1 strategies for rare diseases.

Drug Discov Today

October 2023

European Reference Network for Rare and Complex Epilepsies (EpiCare), Department of Paediatric Clinical Epileptology, Sleep Disorders and Functional Neurology, c/o Pr Arzimanoglou, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677 Bron, France; Department of Child Neurology, UMCU Brain Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Article Synopsis
  • N-of-1 strategies help doctors find out if a treatment works really well for one specific person, especially when they have a rare disease.
  • There’s a debate on whether these strategies should follow rules for research or rules for medical care since they mix both.
  • The text explains how to set up these strategies safely to choose the best treatments for people with rare diseases.
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Nelson's syndrome (NS) is an uncommon disease occurring as a complication of bilateral adrenalectomy (BLA) in patients with persistent Cushing's disease (CD) due to an adrenocorticotropin-producing pituitary tumor. The first reports of this syndrome were done in the 50s, although its pathophysiology is still not understood. Every year, between 1.

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Importance of the reticulocyte hemoglobin equivalent in the exclusion of latent iron deficiency.

Ann Biol Clin (Paris)

July 2023

Clinical laboratory, regional hospital of Ben Arous, Ben Arous, Tunisia., Tunis el Manar university, faculty of medicine of Tunis 1000 Tunis, Tunisia.

Background: Iron deficiency is an underdiagnosed public health problem, especially in developing countries, that can conceal serious underlying illnesses. Early diagnosis and treatment of latent iron deficiency (LID) is crucial. Reticulocyte hemoglobin equivalent (RET-He), was reported to be a cost-effective tool that reflects the iron availability at erythropoiesis.

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Objective: To translate, culturally adapt, and validate a version of the ID Migraine into Latin American Spanish.

Background: Although still considered a common diagnosis, half of the patients with migraine in Latin America experience diagnostic delay. The ID Migraine is a test developed in 2003 as a valuable tool for the early diagnosis of migraine at the primary care level; however, there is no validated Spanish or culturally adapted version for the Spanish-speaking population.

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Purpose: We conducted an observational study to investigate the opinions of neurologists and psychiatrists all around the world who are taking care of patients with seizures [epilepsy and functional seizures (FS)].

Methods: Practicing neurologists and psychiatrists from around the world were invited to participate in an online survey. On 29th September 2022, an e-mail including a questionnaire was sent to the members of the International Research in Epilepsy (IR-Epil) Consortium.

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Background: Lhermitte-Duclos disease (LDD) or dysplastic gangliocytoma of the posterior fossa is a slow-growing and extremely rare mass lesion that involves the Purkinje neurons and the granular layer of the cerebellum. It is characterized by specific neuroradiological features and secondary hydrocephalus. However, documentation of surgical experience is scarce.

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Article Synopsis
  • Adenovirus-based COVID-19 vaccines are widely used in low- and middle-income countries (LMICs), but cases of vaccine-induced cerebral venous sinus thrombosis (CVST) are rarely reported.
  • A study of 228 CVST cases showed 63 from LMICs, with 51% meeting vaccine-induced immune thrombotic thrombocytopenia (VITT) criteria, compared to 62% from high-income countries (HICs).
  • Although clinical manifestations were similar, in-hospital mortality was significantly lower in LMICs (23%) compared to HICs (43%), suggesting different outcomes despite similar treatment approaches.
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Article Synopsis
  • The text discusses a unique case of acute necrotizing encephalopathy in a 26-year-old male who tested positive for SARS-CoV-2, highlighting the scarcity of this condition following COVID-19 infection.
  • It outlines the typical MRI findings, such as symmetrical lesions primarily in the thalamus as well as the brainstem and cerebellum, along with accompanying edema.
  • The article emphasizes the importance of close monitoring and the inclusion of specific MRI sequences in diagnostic protocols for accurate identification of this challenging condition.
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Article Synopsis
  • Frontotemporal dementia (FTD) is a major cause of dementia in people under 65, showing symptoms like unusual behavior or language difficulties depending on the variant.
  • The symptoms and presentation of FTD can differ significantly across cultures and socioeconomic backgrounds, but most current research is based on Western populations.
  • The paper discusses how global diversity influences FTD's diagnosis and treatment, and suggests changes to improve the understanding and management of FTD worldwide.
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Background: Microglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in microglial cells in pathological lesions in the neonatal hypoxic-ischemic encephalopathy (nHIE) model brain.

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Introduction: Alexithymia is a neuropsychiatric symptom conceptualized as difficulty identifying and describing feelings. Although associated with other non-motor symptoms, mainly neuropsychiatric, alexithymia may present as an isolated symptom in persons with Parkinson's Disease (PwP). The objective of the study is to identify determinants of alexithymia and its association with quality of life (QoL) in Parkinson's disease.

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Article Synopsis
  • People with epilepsy in Mexico face significant internalized stigma, which can negatively impact their daily lives and overall quality of life.
  • A study involving 128 patients revealed that factors such as a decreasing quality of life, increased number of anti-seizure medications, and lack of caregiver support are linked to higher levels of internalized stigma.
  • The findings highlight the need for better support systems and interventions to address these issues among individuals with epilepsy.
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Craniopharyngiomas (CPs) are Rathke's cleft-derived benign tumors originating most commonly in the dorsum sellae and representing 2% of intracranial neoplasms. CPs represent one of the more complex intracranial tumors due to their invasive nature, encasing neurovascular structures of the sellar and parasellar regions, making its resection a major challenge for the neurosurgeon with important postoperative morbidity. Nowadays, an endoscopic endonasal approach (EEA) provides an "easier" way for CPs resection allowing a direct route to the tumor with direct visualization of the surrounding structures, diminishing inadvertent injuries, and providing a better outcome for the patient.

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Critical Damage of Lung Parenchyma Complicated with Massive Pneumothorax in COVID-19 Pneumonia.

Clin Med Insights Case Rep

May 2023

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania [Faculty of Medicine, Medical Semiology Department (MIG, DI, DD), Faculty of Medicine, Functional Sciences Department, Physiology Discipline (MCC), Faculty of Medicine, Clinical Neurosciences Department (MM), Faculty of Dental Medicine, Physiology Discipline (AEBS), Faculty of Medicine, Embryology Department (RT)].

It is already known that Coronavirus disease 2019 (COVID-19) may lead to various degrees and forms of lung parenchyma damage, but some cases take a strikingly severe course that is difficult to manage. We report the case of a 62-year old male, non-obese, non-smoker, and non-diabetic, who presented with fever, chills, and shortness of breath. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed by real-time Polymerase Chain Reaction.

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Article Synopsis
  • * It outlines the neuroanatomy and neurophysiology of pain, along with neuroimaging techniques like fMRI, PET, and MEG, which help in understanding pain mechanisms.
  • * The conclusions suggest that better insights into pain and its relation to mental health can enhance chronic pain interventions, particularly in merging data from various neuroimaging approaches for improved clinical strategies.
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