Photocrosslinkable triple helical protein with enhanced higher-order formation for biomaterial applications.

Bacterial collagen, produced via recombinant DNA methods, offers advantages including consistent purity, customizable properties, and reduced allergy potential compared to animal-derived collagen. Its controlled production environment enables tailored features, making it more sustainable, non-pathogenic, and compatible with diverse applications in medicine, cosmetics, and other industries. Research has focused on the engineering of collagen-like proteins to improve their structure and function.

I-CsCO Mediated Intramolecular C2-Amination and Oxidative Rearrangement Cascade of C-3 Phenylthio Indoles: A Route to Synthesize Thiosulfonate-Embedded 2-Iminoindolin-3-ones.

An efficient, transition-metal-free protocol employing I/CsCO for the synthesis of thiosulfonate containing 2-iminoindolin-3-ones motifs has been developed from C-3 phenylthio indoles. The reaction proceeded through intramolecular cyclization involving C-N bond formation, leading to the formation of indole-fused benzothiazines as a key intermediate. Remarkably, CsCO played a crucial role in the reaction as an oxygen source, enabling oxidative rearrangement with [1,4]-sulfonyl migration to furnish the final products with the formation of multiple functional groups such as C═O, C═N, and S-SO.

Investigating the role of corrole as an excitation energy relay in light-induced processes in closely connected N,N'-bis(biphenyl-4-yl)aniline functionalized corrole donor-acceptor dyad.

A photosynthetic antenna-reaction center model, BBA-PFCor comprised of N,N'-bis(biphenyl-4-yl)aniline (BBA) covalently functionalized to bis(pentafluoro)corrole moiety has been prepared and the contribution of the BBA as the photoinduced energy transfer antenna was investigated. UV-visible studies have shown that integrating the electron-rich BBA chromophore into the corrole core has broadened the soret band of the corrole moiety with the absorption spanning from 300 to 700 nm. Electrochemical studies, in corroboration with the computational calculations, revealed that, BBA moiety can act as an electron reservoir and, in the excited state, it would transfer the excited energy to the corrole moiety in the dyad.

Design and evaluation of a multiepitope vaccine for pancreatic cancer using immune-dominant epitopes derived from the signature proteome in expression datasets.

Pancreatic cancer is a highly aggressive and often lethal malignancy with limited treatment options. Its late-stage diagnosis and resistance to conventional therapies make it a significant challenge in oncology. Immunotherapy, particularly cancer vaccines, has emerged as a promising avenue for treating pancreatic cancer.

Uncovering the subtype-specific disease module and the development of drug response prediction models for glioma.

The poor prognosis of glioma patients brought attention to the need for effective therapeutic approaches for precision therapy. Here, we deployed algorithms relying on network medicine and artificial intelligence to design the framework for subtype-specific target identification and drug response prediction in glioma. We identified the driver mutations that were differentially expressed in each subtype of lower-grade glioma and glioblastoma multiforme and were linked to cancer-specific processes.

Effectiveness of Thymol Blue and Phenolphthalein in Sol-Gel Coatings for Sensing and Inhibiting Corrosion on Mild Steel.

Development of smart coatings incorporated with corrosion indicators that can warn of corrosion through signaling the alteration of pH or metal-ion concentration at the corrosion site, and simultaneously mitigate further corrosion, stands out as a highly efficient and economical approach to address corrosion issues. In this context, the present work provides a comprehensive comparison on the effectiveness of thymol blue (TB) and phenolphthalein (PhPh) in both sensing and inhibiting corrosion on mild steel. While most of the works primarily focused on independently investigating the corrosion indication behavior of different active agents, our study intends to offer valuable insights through the comparative analysis of TB and PhPh in making well-informed decisions when selecting the most effective indicator for a given set of application scenarios.

Predictive modelling of methane yield in biochar-amended cheese whey and septage co-digestion: Exploring synergistic effects using Gompertz and neural networks.

This study performed bench scale studies on anaerobic co-digestion of cheese whey and septage mixed with biochar (BC) as additive at various dosages (0.5 g, 1 g, 2 g and 4 g) and total solids (TS) concentrations (5%, 7.5%, 10%,12.

Mesenchymal stem cells-derived extracellular vesicles for therapeutics of renal tuberculosis.

Extrapulmonary tuberculosis with a renal involvement can be a manifestation of a disseminated infection that requires therapeutic intervention, particularly with a decrease in efficacy of conventional regimens. In the present study, we investigated the therapeutic potency of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in the complex anti-tuberculosis treatment (ATT). A rabbit model of renal tuberculosis (rTB) was constructed by injecting of the standard strain Mycobacterium tuberculosis H37Rv into the cortical layer of the kidney parenchyma.

Remediation of Dyes Using Supramolecular Material Derived from Carbohydrate Based π-Gelator Using the Bottom-Up Assembly Approach.

As a consequence of rapid population growth, the earth has faced numerous environmental sustainability issues and crises, water pollution is one of the important points of concern because of industrialization. In particular, effluents discharged from dying industries are rated top among the various industrial effluents, especially by their volume and composition. Annually >7.

Exploring the potential of Eu ions doped heavy metal oxide containing germanium borate glasses for high efficiency red emitting solid-state lasers.

Glasses activated with europium show promising potential for use in applications relating to photonics, in particular solid-state laser generation. In the current work, EuO incorporated gemanium borate glasses were developed and explored their potentiality towards lasing active medium by probing physical, structural, optical and lasing properties in detail. The physical and structural features of each glass indicated the presence of non-bridging oxygens (NBOs) and an enhancement in network stability on account of the inclusion of europium ions into the GeO glass network.

Design, synthesis, anti-mycobacterial activity, molecular docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3 + 2] cycloaddition reaction under ultrasound irradiation.

The development of anti-tuberculosis (anti-TB) drugs has become a challenging task in medicinal chemistry. This is because Mycobacterium tuberculosis (TB), the pathogen that causes tuberculosis, has an increasing number of drug-resistant strains, and existing medication therapies are not very effective. This resistance significantly demands new anti-TB drug profiles.

Simple and Cost-effective Synthesis of a Rare-earth Free Long Afterglow Phosphor for Dark Visual Markings.

Materials with long afterglow (LAG) became very renowned in the field of luminescence due to their high ability to store energy. However, the development of LAG phosphors is mostly dependent on rare-earth activators, which are commercially expensive due to their limited availability across the world. On the other hand, LAG phosphors that are not based on rare-earth and are developed as an alternative cannot compete with existing rare-earth LAG phosphors.

Spatial and temporal classification and prediction of LULC in Brahmani and Baitarni basin using integrated cellular automata models.

Monitoring the dynamics of land use and land cover (LULC) is imperative in the changing climate and evolving urbanization patterns worldwide. The shifts in land use have a significant impact on the hydrological response of watersheds across the globe. Several studies have applied machine learning (ML) algorithms using historical LULC maps along with elevation data and slope for predicting future LULC projections.

Application of apophyllite and thomsonite natural zeolite as modified adsorbents for the removal of zinc from acid mine drainage.

Materials composed of natural zeolite have the potential to serve as highly effective adsorbents in the treatment of wastewater. The present study explores zeolite resin-based Apophyllite and Thomsonite as adsorbents for removing Zinc from acid mine drainage solution. The characteristics of the natural zeolites (Apophyllites and Thomsonite) are investigated using X-ray diffraction, Fourier-transform infrared spectroscopy and Field emission scanning electron microscopy analysis.

Synthesis of Di(thiophen-2-yl) Substituted Pyrene-Pyridine Conjugated Scaffold and DFT Insights: A Selective and Sensitive Colorimetric, and Ratiometric Fluorescent Sensor for Fe(III) Ions.

In this context, we used the multicomponent Chichibabin pyridine synthesis reaction to synthesize a novel di(thiophen-2-yl) substituted and pyrene-pyridine fluorescent molecular hybrid. The computational (DFT and TD-DFT) and experimental investigations were performed to understand the photophysical properties of the synthesized new structural scaffold. The synthesized ligand displays highly selective fluorescent sensing properties towards Fe ions when compared to other competitive metal ions (Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, Na, Ni, Pb, Sr, Sn and Zn).

Investigating temperature variability on antioxidative behavior of synthesized cerium oxide nanoparticle for potential biomedical application.

Cerium oxide nanoparticles (CNP) have garnered significant attention due to their versatile redox properties and wound-healing applications. The antioxidative nature of CNP is due to its ability to be oxidized and reduced, followed by the capture or release of oxygen which is used for scavenging reactive oxygen species (ROS). Herein, CNP is produced through a wet chemistry approach and its tunable redox property is tested across a range of temperatures.

Detection of COVID-19 using edge devices by a light-weight convolutional neural network from chest X-ray images.

Deep learning is a highly significant technology in clinical treatment and diagnostics nowadays. Convolutional Neural Network (CNN) is a new idea in deep learning that is being used in the area of computer vision. The COVID-19 detection is the subject of our medical study.

Optimization of Siderophore Production in Three Marine Bacterial Isolates along with Their Heavy-Metal Chelation and Seed Germination Potential Determination.

Siderophores are low-molecular-weight and high-affinity molecules produced by bacteria under iron-limited conditions. Due to the low iron (III) (Fe) levels in surface waters in the marine environment, microbes produce a variety of siderophores. In the current study, halophilic bacteria SMI_1, sp.

Nested genetic algorithm-based classifier selection and placement in multi-level ensemble framework for effective disease diagnosis.

Effective disease diagnosis is a critical unmet need on a global scale. The intricacies of the numerous disease mechanisms and underlying symptoms make developing a model for early diagnosis and effective treatment extremely difficult. Machine learning (ML) can help to solve some of these issues.

Study on energy use and carbon emission from manufacturing of OPC and blended cements in India.

The demand for production of cements is ever increasing to meet the infrastructure development globally. The energy and emission factors available for cements in most of the life cycle assessment (LCA) databases may not exactly suit for all the geographical locations. The main challenge in Indian scenario is the absence of database for LCA study.

Mutations in V84I & A184V of cluster plays a pivotal role in the dynamics of Ω-loop leading to genesis of IR-TEM.

The family exhibits resistance to antibiotics by producing β-Lactamase. Mutations in β-Lactamase, have led to the generation of inhibitor resistant variants known as IR-TEM. In the present study, IR-TEM β-Lactamase of and was compared.

ZIF-8 decorated cellulose acetate mixed matrix membrane: An efficient approach for textile effluent treatment.

The textile industry is the second largest water-intensive industry and generates enormous wastewater. The dyes and heavy metals present in the textile effluent, even at their lower concentrations, can cause an adverse effect on the environment and human health. Recently, mixed matrix membranes have gained massive attention due to membrane property enhancement caused by incorporating nanofillers/additives in the polymer matrix.

Sustainable environmental practices of tea waste-a comprehensive review.

Tea, the major beverage worldwide, is one of the oldest commercial commodities traded from ancient times. Apart from many of its advantages, including health, socio-economic, climatic, and agro-ecological values, FAO has recognized that the tea value chain covering its growth in the field, processing and marketing, and finally, the hot cup at the user's hand needs to be made sustainable during all these stages. Tea generates a lot of waste in different forms in different stages of its growth and processing, and these wastes, if not managed properly, may cause environmental pollution.

Studies on a novel SrZr CaLa O :Eu phosphor for lighting applications emitting direct white light.

Direct white light emitting phosphors play a significant role in the display industry due to their ability to improve the quality, efficiency, and versatility of lighting sources used in most of the displays. The currently investigated phosphor SrZr CaLa O :Eu was prepared by a conventional solid-state reaction method. It has been observed that the stoichiometric ratio of all precursors plays an important role in determining the characteristics of the final phosphor.