4 results match your criteria: "National Institute of Pediatrics Mexico City[Affiliation]"

Article Synopsis
  • Patients with a skin condition called epidermolysis bullosa (EB) often have problems with their nails because of issues with the skin beneath them.
  • A study looked at 36 articles about nail problems in 74 individuals with EB, finding that most had severe nail issues, like missing nails.
  • The study showed that missing nails (anonychia) were more common in people with severe forms of EB and that more research is needed to understand how nail problems relate to the overall health of these patients.
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The alternative splicing plays an important role to generate protein diversity. Recent studies have shown alterations in alternative splicing, resulting in loss, gain or changes of functions in the resulting protein. Specific products of alternative splicing are known to contribute in cancer-related mechanisms, such as angiogenesis, migration, adhesion and cell proliferation, among others.

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Detection of apoptosis in pemphigus vulgaris by TUNEL technique.

An Bras Dermatol

April 2017

Southern Associated Pathologists "Specialists in Pathology Laboratories" - Mexico City, Mexico.

Article Synopsis
  • Pemphigus is an autoimmune blistering disease affecting skin and mucous membranes, caused by autoantibodies targeting keratinocyte components, but its severity isn't solely linked to these antibody levels.
  • This study involved 15 tissue samples from pemphigus vulgaris patients, which underwent TUNEL assays to assess apoptosis in skin cells.
  • The results showed high positivity for apoptosis in basal layer cells and other affected layers, indicating that apoptosis plays a key role in the disease's mechanism, suggesting potential for developing new treatments targeting apoptosis.
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