[Effect of ERK/JNK cell signaling pathway in carbon black induced cytokine IL-6 and IL-8 expression changes].

Objective: To investigate the roles of extracellular signal-regulated kinase(ERK)/c-Jun amino-terminal kinase(JNK) signaling pathway on the expression of interleukin-6(IL-6) and interleukin-8(IL-8) in human embryonic lung fibroblasts(HELF) induced by carbon black.

Methods: HELFs were cultured in RPMI-1640 medium containing 0, 15, 30, 60, 120 or 240 μg/mL carbon black for 24 h, and the appropriate dose of carbon black was determined by MTT assay result HELFs were divided into three groups: HELFs, HELFs transfected with ERK dominant negative mutant plasmid(DN-ERK) and HELFs transfected with JNK dominant negative mutant plasmid(DN-JNK). 100 μg/mL carbon black was used to treat HELFs(CB), DN-ERK HELFs(CB-DN-ERK), DN-JNK HELFs(CB-DN-JNK), and HELFs without any black carbon treatment were considered as control group.

Associations of age at natural menopause and occupations in Chinese female workers: A cross-sectional study.

Aims: To investigate the impact of occupation types on age at natural menopause.

Methods: This is a nation-wide cross-sectional study based on 17,948 female workers aged over 40, who come from different industries or organizations. A face-to-face standardized questionnaire was conducted in all participants with the help of occupational hygienists.

[Determination of mifepristone in workplace air by ultra-performance liquid chromatography].

To establish an ultra-high performance liquid chromatography method for the determination of mifepristone in the air of workplaces. From January to July 2018, glass fiber filter membrane was used to collect mifepristone in the workplace air, eluted with acetonitrile/water solution, and determined by ultra-high performance liquid chromatography-UV method. The detection limit of mifepristone determination method was 0.

Cohort profile: China National Human Biomonitoring (CNHBM)-A nationally representative, prospective cohort in Chinese population.

Objective: Globally, developed countries such as the United States, Canada, Germany, Korea, have carried out long-term and systematic biomonitoring programs for environmental chemicals in their populations. The China National Human Biomonitoring (CNHBM) was to document the extent of human exposure to a wide array of environmental chemicals, to understand exposure profiles, magnitude and ongoing trends in exposure in the general Chinese population, and to establish a national biorepository.

Methods: CNHBM adopted three-stage sampling method to obtain a nationally representative sample of the population.

[A preliminary study on establishment of the Core Occupational Stress Scale (COSS) norms for manufacturing and medical workers in China].

To establish the Core Occupational Stress Scale (COSS) norm values for manufacturing and medical workers. A total of 10 316 manufacturing workers of 20 companies from 7 provincial capital cities and 5 031 medical workers of 19 hospitals from 4 provincial capital cities were investigated using a stratified sampling method. Questionnaire information including occupational stress was collected.

[Development of the Core Occupational Stress Scale for occupational populations in China].

To develop the Core Occupational Stress Scale (COSS) for key occupational populations, and to assess the reliability and validity of COSS in China. According to the literature review, in-depth interview and expert evaluation, the item pool of COSS was established. A total of 20 981 employees (3 703 employees from 2018 and 17 178 employees from 2019) of manufacturing, medical, and traffic polices, etc.

[Determination of N-[4- (4-aminobenzyl) -phenyl] acetamide hemoglobin adduct in blood by ultra performance liquid chromatography-tandem mass spectrometry].

To establish the method for the determination of N-Acetyl-4, 4'-diaminodiphenylmethane (AcMDA) adduct in the hemoglobin by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) . The 20 mg hemoglobin sample was weighed into a 15 ml centrifuge tube, adding 20 μg/L internal standard solution AcMDA-D8 10 μl, then hydrolyzed with 1 ml 0.1 mol/L sodium hydroxide solution at 37°C for 0.

Acute Effects of Individual Exposure to Fine Particulate Matter on Pulmonary Function in Schoolchildren.

Objective: This panel study aimed to determine the acute effects of exposure to fine particulate matter (PM ) on schoolchildren's pulmonary function.

Methods: We selected 51 schoolchildren aged 9-12 years attending a full-time boarding school in Beijing, China, measured the indoor and outdoor PM concentrations for five consecutive days, calculated the PM time-weighted individual exposure levels based on the school micro-environmental concentrations and the time activity pattern recorded by schoolchildren, measured schoolchildren's pulmonary function on the fifth day. The survey was performed three times from December 2018 to April 2019.

Respiratory effects induced by occupational exposure to refractory ceramic fibers.

Refractory ceramic fibers (RCFs) are increasingly used as heating-insulated materials in various industries. However, toxicological and epidemiological studies focusing on the adverse effects of RCFs were still insufficient, particularly in China. We conducted a cross-sectional study to evaluate comprehensively the associations between occupational exposure to RCFs and respiratory health effects among Chinese workers.

[Role of LINC00310 in the glycidyl methacrylate-induced malignant transformation of human bronchial epithelial cell].

Objective: To investigate the expression and biological significance of LINC00310 in the malignant transformation of human bronchial epithelial cells(16 HBE) induced by glycidyl methacrylate(GMA).

Methods: The 16 HBE cells recovered successfully used 1 μg/mL dimethyl sulfoxide(DMSO) as the solvent control group, and the final concentration was 8 μg/mL GMA as the treatment group, and were subcultured after repeated exposure 3 times for 72 hours each time. The 10 th, 20 th and 30 th generation cells of the GMA treatment group and corresponding DMSO control group were collected.

Polycyclic aromatic hydrocarbons in particulate matter and serum club cell secretory protein change among schoolchildren: A molecular epidemiology study.

Airborne particulate matter (PM) is a complex mixture containing various kinds of harmful components. Exposure to air PM is associated with childhood respiratory disease, but epidemiological data are limited concerning the circulating respiratory injury protein on the etiology of childhood respiratory disease. Specifically, the role of PM toxic components or its biological effective dose (adduct) in respiratory injury remains unclear.

[The difference of surface electromyography data processing method based on simulated manal-lifting-task].

To study the differences of different signal processing method of surface electromyography (sEMG) in judging muscle fatigue. From July to October 2019, based on the model of simulated manual lifting operation, the original sEMG signals from 13 volunteers of brachial radial muscle, brachial two-headed muscle, triangle muscle, left vertical spine muscle, right vertical spine muscle and lateral femoral muscle were collected in the operation activities. Three different electromyography signal processing methods (all signal from motion beginning to the end, peak signal and ehe specified motion signal) were used to analyze the original data in time domain (RMS) and frequency domain (MDF) , the data difference between different electromyography signal processing methods was analyzed by using Wilcoxon rank and sum test and nonlinear curve fitting method.

Molecular epidemiology of Brucella abortus strains from cattle in Inner Mongolia, China.

Although the prevalence of brucellosis in Inner Mongolia Autonomous Region currently remains high, data available on the epidemiological of circulating Brucella abortus strains were limited. A total of 75 isolates obtained from cattle, sheep, and humans were analysed using both the classical method and multiple locus variable-number tandem repeat analysis (MLVA). There are at least three B.

New Metrics Needed in the Evaluation of Hearing Hazard Associated With Industrial Noise Exposure.

Objectives: To evaluate (1) the accuracy of the International Organization for Standardization (ISO) standard ISO 1999 [(2013), International Organization for Standardization, Geneva, Switzerland] predictions of noise-induced permanent threshold shift (NIPTS) in workers exposed to various types of high-intensity noise levels, and (2) the role of the kurtosis metric in assessing noise-induced hearing loss (NIHL).

Design: Audiometric and shift-long noise exposure data were acquired from a population (N = 2,333) of screened workers from 34 industries in China. The entire cohort was exclusively divided into subgroups based on four noise exposure levels (85 ≤ LAeq.

Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway.

Acrylamide has been shown to be neurotoxic. Brain-derived neurotrophic factor (BDNF) can alleviate acrylamide-induced synaptic injury; however, the underlying mechanism remains unclear. In this study, dibutyryl-cyclic adenosine monophosphate-induced mature human neuroblastoma (NB-1) cells were exposed with 0-100 μg/mL acrylamide for 24-72 hours.

Waterborne Arsenic Poisoning Caused by Discarded Slags - Yongzhou City, Hunan Province, China, 2018.

Overexposure to arsenic is toxic and affects bodily systems. In severe cases, loss of motor function and death can occur. At the end of 2018, a waterborne acute arsenic poisoning event occurred in Yongzhou City of Hunan Province because arsenic-containing slags contaminated the water supply, which resulted in 10 people being poisoned.

Noise Exposure Level of Coal-Fired Thermal Power Stations in Different Scales - China, 2017-2019.

China is a country mainly based on thermal power generation. Noise is one of the most critical occupational hazards among thermal power stations. The proportion of detected environmental noise that exceeded 85 dB(A) is 69.

Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells.

Lung cancer has been the leading cause of cancer incidence and mortality in China for years. Benzo[a]pyrene (BaP) is a well-known carcinogen for lung cancer. To understand alternation of key proteins and their role in BaP-induced lung cancer, we compared proteome profiles between BaP-transformed 16HBE cell line T-16HBE-C1 (THBEc1) cells and control using label-free quantitative proteomic analysis.

Poisonings Caused by Wild Mushroom Containing Amanitin Toxins - Shaoxing City, Zhejiang Province, China, 2019.

Among all food poisoning, poisonings caused by wild mushrooms containing amanitin toxins have the highest case fatality rate. Amanitin toxins can cause acute liver function damage, and symptoms of the poisoning can include vomiting and diarrhea in early stages and progressive liver damage 2-3 days later. Before 2019, there were about 1-2 cases of wild mushroom containing amanitin toxins poisoning each year in Zhejiang Province.

Read-across: Principle, case study and its potential regulatory application in China.

Read-across, has generated much attention and has been used in many regulatory schemes as an alternative approach to testing globally. The regulatory application of read-across in the chemical management in China is progressing but still limited. A workshop on the "Read-across: Principle, case study and its potential regulatory application in China", organized by the Chemical Risk Assessment Specialty Group under the Committee of Industrial Toxicology of Chinese Society of Toxicology, was held on May 28, 2019 to discuss the potential broader application and acceptance of read-across to support chemical risk assessment in China.

[Status analysis of standard methods for detecting metals and metalloids in the air of workplace in China].

To provide basis for improving the detection standard methods and improve the quality and applicability of the occupational health detection standard methods. This paper is based on occupational health standards and experimental data at home and abroad. Analysis the detection standard methods of metal and metalloid in the air of workplace through data collection, investigation and experiments.

[Application of an occupational health risk assessment method in dioctyl phthalate producing enterprise].

To find the risk assessment model of [di (2-ethylhexyl) phthalate, DEHP] fitting well for producing companies. The Cluster Sampling method was used in selecting a DEHP producing company in the occupational health and workplace environment monitoring study conducted between July and August in 2017. Data was collected by site evaluating and workplace environment monitoring.

[Study on the pharmacokinetics of bromadiolone in oral poisoning rabbits].

To investigate the variations of bromadiolone concentration in blood and its metabolism in rabbits after oral administration of bromadiolone, and to provide reference for the study of bromadiolone metabolism. Designed absolute alcohol (1 g/kg) reagent control group, high dose (0.3 mg/kg) and low dose group (0.

Effects of high potassium iodate intake on iodine metabolism and antioxidant capacity in rats.

Background: KIO and KI are the most common salt iodization agents. Coincidentally, iodine exists naturally in high-iodine drinking water in the form of iodide (I) or iodate (IO). As an oxidizing substance, IO should be reduced to I before it can be effectively used by the thyroid.