400 results match your criteria: "National Institute of Occupational Health and Poison Control[Affiliation]"

What Is Already Known About This Topic?: Mushroom poisoning incidents are one of the major causes of death by foodborne outbreaks in China. Effective detection and identification can provide the foundation for determining the cause of the incidents and the early diagnosis and treatment of patients.

What Is Added By This Report?: The surveillance data from the Public Health Emergency Management Information System, China CDC, showed that incidents with laboratory test results as the basis for determining the cause of mushroom poisoning accounted for only 14.

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What Is Already Known About This Topic?: Lower extremity musculoskeletal diseases (LE-MSDs) have emerged as a significant contributor to the global disease economic burden and worker absenteeism, becoming a global public health concern. However, the epidemic characteristics of LE-MSDs among occupational populations in China are unknown.

What Is Added By This Report?: This report finds that the LE-MSDs prevalence rate among key occupational groups in China is 17.

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[Interpretation of Ergonomic guidelines for the prevention of work-related musculoskeletal disorders part 6: Wooden furniture manufacturing work (T/WSJD 14.6-2024)].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

December 2024

Guangzhou Twelfth People's Hospital, Guangzhou Occupational Disease Prevention and Treatment Hospital, Key Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, Guangzhou 510620, China.

"Ergonomic guidelines for the prevention of work-related musculoskeletal disorders Part 6: Wooden furniture manufacturing work" provides comprehensive preventive measures for China's wooden furniture manufacturing industry, covering scope of application, hazard factors identification, potential affected areas, intervention measures and effect evaluation. Through systematic ergonomics strategies, the guide emphasizes improving the working environment, cultivating employee awareness, eliminating hazard factors, and providing practical guidance for creating a healthy and safe working environment. This article interprets and analyzes the standard project background, formulation process, basic basis and main content to help relevant practitioners more fully understand and implement the ergonomics scheme proposed by the standard, and provide enterprises with scientific and accurate technical support.

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[Structural equation analysis and modeling of adverse ergonomic factors for lower back pain].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

December 2024

Laboratory of Occupational Protection and Ergonomics, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Article Synopsis
  • The study aimed to create a structural equation model to analyze lower back pain and its risk factors among workers in China, based on data from nearly 74,500 cases collected through an epidemiological survey.
  • Using confirmatory factor analysis, researchers identified key factors affecting lower back pain, including individual characteristics, work organization, working postures, work types, and muscle fatigue, which were grouped into six categories.
  • The model demonstrated good reliability and validity with strong correlations among the identified factors, highlighting that work organization and working postures significantly influence lower back pain, along with a notable linkage between work types and postures.
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[Structural equation analysis and modeling of wrist WMSDs and its adverse ergonomic factors].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

December 2024

Laboratory of Occupational Protection and Ergonomics, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To investigate the relationships and impacts between various occupational ergonomic hazards and hand and wrist fatigue, as well as work-related musculoskeletal disorders (WMSDs) of the hand and wrist, and to propose targeted preventive and intervention measures for adverse occupational ergonomic factors causing WMSDs of the hand and wrist. From 2018 to December 2023, a nationwide epidemiologic survey study of wrist WMSDs was conducted using the Chinese version of the electronic questionnaire system for musculoskeletal disorders.A total of 88, 609 valid questionnaires were collected.

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[Effects of muscle fatigue on urine metabolites in automobile manufacturing workers based on untargeted metabolomics].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

December 2024

Laboratory of Occupational Protection and Ergonomics Research, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To investigate the changes of metabolites in urine of automobile manufacturing workers with muscle fatigue using metabolomics technology, and to explore potential biomarkers and disrupted metabolic pathways. In July 2022, urine samples were collected from 35 male workers in a certain automobile manufacturing industry before and after muscle fatigue, and metabolite analysis was conducted. Subsequently, multivariate statistical analysis was used for data processing to screen differential metabolites.

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[Study on the relationship between occupational exposure characteristics and musculoskeletal disorders in 29 industries or workforce groups in China].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

December 2024

Laboratory of Occupational Protection and Ergonomics, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Article Synopsis
  • The study investigates work-related musculoskeletal disorders (WMSDs) among different occupational groups in China, analyzing the impact of various job-related factors on their occurrence.
  • Data was collected from 88,609 workers across 441 enterprises over a five-year period, utilizing retrospective surveys to determine the relationship between WMSDs and occupational factors through statistical analysis.
  • Key findings show a significant correlation between WMSDs and factors like poor posture, repetitive tasks, and heavy object handling, with certain demographics, such as working age and gender, also influencing the risk of developing these disorders.
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[Study on the epidemiological characteristics of work-related musculoskeletal disorders among 29 industries or occupational groups in China].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

December 2024

Laboratory of Occupational Protection and Ergonomics, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To analyze the distribution characteristics of work-related musculoskeletal disorders (WMSDs) among the occupational population in China's key industries during the period from 2018 to 2023, and to provide data support for the formulation of targeted prevention strategies. Between January 1, 2018, and December 31, 2023, a cross-sectional epidemiological survey and a retrospective investigation were conducted in seven geographical regions of North China, East China, Central China, South China, Southwest China, Northwest China, and Northeast China, using a combination of epidemiological cross-sectional and retrospective surveys. The industries were stratified according to the degree of closeness to WMSDs, the size of the occupational population, and the importance of the national economy, and then cluster sampling was conducted according to the size of the enterprises (large, medium, and small) within each stratum.

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Background: Maduramicin (MAD) is an anticoccidial veterinary drug, but it frequently causes fatal poisonings in poultry, livestock, or humans. However, there is no specific antidote or guidance on first aid for MAD poisoning.

Aim: The aim of the present study is to evaluate the acute toxicity and toxicokinetics of MAD after oral exposure, so as to make a foundation for developing diagnostic and therapeutic protocols for human intoxication.

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Discrimination of wild edible and poisonous fungi with similar appearance (Cantharellus albovenosus vs Omphalotus olearius) based on lipidomics using UHPLC-HR-AM/MS/MS.

Food Chem

February 2025

National Demonstration Center for Experimental Ethnopharmacology Education, School of Pharmaceutical Sciences, (South-Central MinZu University), Wuhan 430074, PR China. Electronic address:

Mushrooms have long been appreciated as a delicacy as well as used as vital dietary supplements and food. However, poisoning from mushroom consumption remains a worldwide health problem, resulting in morbidity and mortality. In this paper, for the first time an untargeted lipidomics analysis on Omphalotus olearius (O.

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Article Synopsis
  • Silicosis is an occupational lung disease causing lung fibrosis and poses a significant risk to workers due to a lack of effective treatments.
  • Researchers developed in vitro and in vivo models of silicosis, utilizing scRNA-sequencing to analyze lung tissue and discovered that silica nanoparticles (SiNPs) induce macrophage pyroptosis, leading to a shift in fibroblasts toward myofibroblasts.
  • The study reveals how exosomes from pyroptotic macrophages influence pro-fibrotic signaling, suggesting that SiNP exposure exacerbates lung fibrosis and highlighting potential new therapeutic targets for silicosis.
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Background: The human gut microbiome develops rapidly during infancy, a key window of development coinciding with the maturation of the adaptive immune system. However, little is known about the microbiome growth dynamics over the first few months of life and whether there are any generalizable patterns across human populations. We performed metagenomic sequencing on stool samples ( = 94) from a cohort of infants ( = 15) at monthly intervals in the first 6 months of life, augmenting our dataset with seven published studies for a total of 4,441 metagenomes from 1,162 infants.

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Engineering Macrophage-Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis.

Adv Healthc Mater

October 2024

Clinical Medical Research Center for Women and Children Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250001, China.

Silicosis is a severe lung disease characterized by diffuse pulmonary fibrosis, for which there is currently no effective treatment. Pirfenidone (PFD) shows great antifibrotic potential but is clinically hindered by low bioavailability and gastrointestinal side effects. To address these limitations, this study develops a PFD delivery system (PFD-Exo) using J774A.

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A network pharmacology approach-based decoding of Resveratrol's anti-fibrotic mechanisms.

Phytomedicine

December 2024

School of Public Health, North China University of Science and Technology, Tangshan 063000, China; Xinxiang Medical University, Xinxiang 453000, China. Electronic address:

Article Synopsis
  • Inhalation of crystalline silica (CS) can cause serious lung issues like chronic inflammation and pulmonary fibrosis (PF), which currently has few effective treatments.
  • This study is the first to explore how resveratrol (Res) may help treat PF by using a mix of network pharmacology and experimental methods to understand its effects better.
  • Results revealed that Res can reduce lung damage and other harmful effects by influencing the autophagy signaling pathway, specifically targeting the AMPK/mTOR pathway, highlighting its potential as a treatment for PF.
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Background: Mushroom poisoning is a significant food safety issue in Guizhou Province, China. Studies on this topic are essential for its prevention and control. We aimed to analyze the epidemiological characteristics of mushroom poisoning and study the correlation between its cases and meteorological factors in Guizhou Province.

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Analysis and study on biomarkers of local muscle fatigue caused by repetitive lifting task.

BMC Musculoskelet Disord

August 2024

National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.

Article Synopsis
  • Work-related musculoskeletal disorders (WMSDs) are increasingly common and pose significant economic and health challenges, prompting this study to investigate muscle fatigue response and identify early warning biomarkers for prevention.* -
  • Thirteen male college students participated in a laboratory experiment involving repetitive lifting tasks, during which muscle fatigue was measured using perceived exertion ratings and sEMG analyses, and various blood biomarkers were analyzed.* -
  • Results indicated that after fatiguing activities, serum levels of multiple metabolic markers (like ammonia and lactic acid) and pain markers significantly increased, suggesting a correlation between these biomarkers and muscle fatigue.*
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Mushroom poisoning of Panaeolus subbalteatus from Ningxia, northwest China, with species identification and tryptamine detection.

Toxicon

August 2024

School of Public Health, Ningxia Key Laboratory of Environmental Factors and Chronic Diseases Control, Ningxia Medical University, Yinchuan, Ningxia, China; Physical and Chemical Department, Ningxia Hui Autonomous Region Center for Disease Control and Prevention, Yinchuan, Ningxia, China. Electronic address:

Mushroom poisoning is a significant contributor to foodborne disease outbreaks in China. This study focuses on two Panaeolus subbalteatus poisoning incidents accompanied by epidemiological investigations, species identification, and toxin detection in Ningxia, northwest China. In these two poisoning incidents, some patients exhibited gastrointestinal or neurological symptoms approximately 0.

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[EQ-5D-3L based quality of life for patients of pneumoconiosis combined with tuberculosis and its influencing factors].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

June 2024

National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Article Synopsis
  • The study aimed to assess the health-related quality of life for patients suffering from pneumoconiosis combined with tuberculosis in China, involving 951 patients over a period of four years.
  • It revealed that the most common type of pneumoconiosis was silicosis with tuberculosis, and a significant portion of patients also had other chronic diseases.
  • The results showed lower health utility and self-rating scores for these patients compared to those with pneumoconiosis alone, with notable differences in their quality of life based on urban versus rural residency as well as high instances of pain and discomfort reported.
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Objectives: Although studies have shown that work-related musculoskeletal disorders (WMSDs) are common and continue to be a major source of disability and work time loss, there are few reports about elbow WMSDs. The aim of this study was to explore the prevalence and associated factors of elbow WMSDs.

Methods: The valid questionnaires of 57501 workers from 15 different industries nationwide were collected and the c2 test and logistic regression analysis were applied to reveal the prevalence and risk factors of elbow WMSDs.

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What Is Already Known About This Topic?: () is a species of toxic mushroom known to induce symptoms of photosensitive dermatitis.

What Is Added By This Report?: In the months of May and June 2023, a total of four patients in Chuxiong Yi Autonomous Prefecture, Yunnan Province, were affected by poisoning, occurring over two distinct incidents. The condition of two patients deteriorated after they were re-exposed to sunlight on the seventh day following the initial poisoning.

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Association of noise exposure with lipid metabolism among Chinese adults: mediation role of obesity indices.

J Endocrinol Invest

January 2025

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

Purpose: Noise exposure in the workplace has been linked to a number of health consequences. Our objectives were to explore the relationship between occupational noise and lipid metabolism and evaluate the possible mediating effect of obesity indices in those relationships with a cross-sectional study design.

Methods: Cumulative noise exposure (CNE) was used to measure the level of noise exposure.

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[Analysis of the change in human resources of centers for disease control and prevention in different regions of China from 2010 to 2020].

Zhonghua Yu Fang Yi Xue Za Zhi

May 2024

China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

To analyze the change in human resources within China's Centers for Disease Control and Prevention (CDC) from 2010 to 2020. The self-reported information from provincial, prefectural (city), and county (district) levels of China's CDC, covering employee counts, staff composition, professional qualifications, educational backgrounds, technical titles, and tenure, were extracted from the China Disease Prevention and Control Information System. The demographic context was provided by the annual population figures from the China Statistical Yearbook (2010-2020).

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Association of noise exposure, plasma microRNAs with metabolic syndrome and its components among Chinese adults.

Sci Total Environ

April 2024

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education, Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address:

Article Synopsis
  • The study aimed to investigate the link between occupational noise exposure and metabolic syndrome (MetS), as well as explore the potential involvement of microRNAs (miRNAs) in this association.
  • The analysis involved 854 participants, using logistic regression to examine the relationships between cumulative noise exposure, miRNAs, and various components of MetS, adjusting for influencing factors.
  • Results indicated a positive correlation between occupational noise and MetS prevalence, along with specific health issues like high blood pressure and lower HDL cholesterol; however, miRNAs did not show significant mediation in these relationships.
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Mushroom Poisoning Outbreaks - China, 2023.

China CDC Wkly

January 2024

National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China.

What Is Already Known About This Topic?: Mushroom poisoning poses a significant food safety concern in China, with a total of 196 species identified in poisoning incidents by the end of 2022.

What Is Added By This Report?: In 2023, the China CDC conducted an investigation into 505 cases of mushroom poisoning spanning 24 provincial-level administrative divisions. This investigation resulted in 1,303 patients and 16 deaths, yielding a case fatality rate of 1.

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What Is Already Known About This Topic?: Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of China. These toxins primarily induce gastrointestinal symptoms initially, which are then followed by potentially life-threatening acute liver damage.

What Is Added By This Report?: This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai City.

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