Multidimensional Approach of Genotype and Phenotype in Stroke Etiology: The MAGPIE Study.

Background And Aims: Stroke is a leading cause of mortality and morbidity in Bangladesh. It is estimated that genetic determinants account for around 40%-60% of its etiology, similar to environmental factors. This study aimed to provide a better understanding of the genetic, environmental, and clinical risk factors in stroke patients from Bangladesh.

Prevalence of epilepsy in Bangladesh: Results from a national household survey.

Objective: To determine the prevalence and types of epilepsy in Bangladesh.

Methods: We conducted a nationwide population-based cross-sectional survey among Bangladeshi population of all ages, except children under one month. We surveyed 9839 participants (urban, 4918; rural, 4920) recruited at their households using multistage cluster sampling.

Toll-like receptor-4 299Gly allele is associated with Guillain-Barré syndrome in Bangladesh.

Objective: TLR4 plays an important role in the pathogenesis of Guillain-Barré syndrome (GBS). The relationships between polymorphisms and susceptibility to GBS are poorly understood. We investigated the frequency and assessed the association of two single nucleotide polymorphisms (SNPs) in the extracellular domain of (Asp299Gly and Thr399Ile) with disease susceptibility and the clinical features of GBS in a Bangladeshi cohort.

Risk factors for respiratory failure in Guillain-Barré syndrome in Bangladesh: a prospective study.

Objective: We investigated clinical, biological, and electrophysiological risk factors for mechanical ventilation (MV) and patient outcomes in Bangladesh using one of the largest, prospective Guillain-Barré syndrome (GBS) cohorts in developing world.

Methods: A total of 693 GBS patients were included in two GBS studies conducted between 2006 and 2016 in Dhaka, Bangladesh. Associations between baseline characteristics and MV were tested using Fisher's exact test, χ test, or Mann-Whitney -test, as appropriate.

Zika virus and Guillain-Barré syndrome in Bangladesh.

Objective: Previous studies have associated Guillain-Barré syndrome (GBS) with Zika virus (ZIKV) outbreaks in South America and Oceania. In Asia, ZIKV is known to circulate widely, but the association with Guillain-Barré syndrome is unclear. We investigated whether endemic ZIKV infection is associated with the development of GBS.