5,249 results match your criteria: "National Institute of Mental Health and Neurosciences[Affiliation]"

Article Synopsis
  • Advances in genetic testing have revealed that many cases of early onset Parkinson disease (EOPD) have genetic causes, either through specific genes with single-gene inheritance or risk factor genes that increase susceptibility.
  • The genetic complexity of EOPD presents challenges, as variations in the same gene can cause a wide range of symptoms, and different genes can lead to similar symptoms, complicating diagnosis and treatment.
  • This review aims to explore the relationship between specific PARK genes and EOPD, detailing how these genetic factors influence clinical symptoms, underlying mechanisms, investigation outcomes, and responses to treatment options.
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Objectives: Available literature highlights the effectiveness of Acupuncture or Acupressure on the Spleen 6 acupoint ( or SP-6) for pain management in primary dysmenorrhea (PD). The objective of the current systematic review and meta-analysis is to provide an updated assessment of available randomized and non-randomized controlled trials and to compare the effectiveness of acupressure and acupuncture stimulation of among patients with PD.

Methods: We conducted a comprehensive literature search on various electronic databases including Embase, PubMed, and the Cochrane Library from January 1990 to March 2023 to identify the comparative studies (randomized and non-randomized controlled trials) that assessed the effects of acupressure or acupuncture on the acupoint in patients with PD.

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Article Synopsis
  • Researchers found a long noncoding RNA called RIM28 that inhibits the tumor suppressor p53 in glioblastoma (GBM) and glioma stem-like cells (GSC), leading to worse cancer outcomes.
  • This RNA interacts with a specific mRNA that increases TRIM28 protein, which in turn decreases p53 levels through enhanced ubiquitination, reducing the effectiveness of p53's DNA damage response.
  • Silencing RIM28 suppressed GSC growth and reduced glioma tumors, while its overexpression promoted tumor growth and resistance to the chemotherapy drug Temozolomide, suggesting it could be a potential therapeutic target for GBM treatments.
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Article Synopsis
  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Objective: Recessive variants in the PINK1 gene are known causes of early-onset Parkinson's disease (EOPD). To describe the clinical features and genetic profiles of patients with PINK1-related Parkinson's disease (PARK-PINK1) mutations.

Methods: We conducted a retrospective chart review of the demographic, clinical and genetic details of patients from our database carrying biallelic PINK1 variants.

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Background: The importance of evidence-informed health policymaking is widely recognized. However, many low- and middle-income countries lack evidence-informed mental health policies due to insufficient data, stigma or lack of resources. Various policies address adolescent mental health in India, but published knowledge on their evidence-informed nature is limited.

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Background: Severe mental disorders during childhood and adolescence can be chronic and disturbing, and may result in serious impairments in functioning. Research on the influence of such factors in the functional recovery of children diagnosed with severe mental illnesses is scant. This study aims to enhance understanding of the patterns and descriptions of social factors in the optimal functioning of children with severe mental illnesses.

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In the past few decades, super-specialization has gained popularity in many medical disciplines. It provides professionals with a sturdy platform for advanced research and helps to deliver focused and extensive care in the fields of trauma and critical care, which can translate into good clinical outcomes for patients. Although this drift may bring about novel research opportunities, it may limit the number of doctors attending to the basic healthcare needs of the population.

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Background: Trigeminal neuralgia is a debilitating disease, with severe recurrent paroxysms of shock-like facial pain. Although pharmacotherapy may suffice in the majority of cases, a proportion of patients require surgical treatment. Gamma knife radiosurgery (GKRS) represents a potential noninvasive alternative to surgery in these patients.

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The WHO Flexible Interview for ICD-11 (FLII-11).

World Psychiatry

October 2024

Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

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Identification of Putative Biomarkers in Cerebral Palsy: A Meta-Analysis and Meta-Regression.

Pediatr Neurol

December 2024

Neuro Medical-Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Electronic address:

Background: Cerebral palsy (CP) is a neurological disorder that impairs motor abilities. Identifying maternal biomarker derangements can facilitate further evaluation for early diagnosis, potentially leading to improved clinical outcomes. This study investigates the association between maternal biomarker derangements and CP development during the antenatal period.

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Background: Dance as therapy is gaining attention as an adjuvant option for Parkinson's disease (PD). Assessing culturally popular dance forms is crucial for promoting the acceptance of dance therapy in a culturally sensitive context.

Objectives: The pilot study evaluated the efficacy of Garba dance for alleviating motor symptoms, nonmotor symptoms, cognitive functions, and mood.

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Exploring the Potential Long-term Impact of SARS-CoV-2 on Protein Misfolding and Amyloid-related Conditions.

Protein Pept Lett

November 2024

Vellore Institute of Technology, Centre for Bio Separation Technology (CBST), Technology Tower, VIT University, Vellore, Tamil Nadu 632014, India.

The long-term impact of the COVID-19 pandemic concerns risk to human health, particularly its potential association with protein misfolding and amyloidosis. This review article explores the causality relationship between SARS-CoV-2 infection, and protein misfolding, leading to amyloid-related conditions. It delves into the mechanisms by which viral proteins may accelerate amyloid formation, exacerbating post-infection complications, including neurological sequelae.

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Article Synopsis
  • * Out of 250 cases, NMOSD had a higher rate of autoantibody positivity (25.5%) compared to MOGAD (12.2%), and double antibody positivity was also more common in NMOSD (5.9% vs. 1.4%).
  • * The study found that NMOSD patients with positive autoant
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The tripartite classification of mental faculties into cognition, affect, and conation (motivation and action) continues to be the edifice on which the mind and the methods to address mental afflictions are studied. Eastern spiritual traditions offer insights into mental health as it pertains to each of these domains. Following up on our previous paper on the cognition path to psychotherapy (Knowing oneself, or Jnana Yoga), we herein focus on the path of selfless action (Karma Yoga).

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Cyberbullying is bullying with the use of digital technologies, which can take place on social media, messaging platforms, gaming platforms, and mobile phones. It is repeated behavior aimed at scaring, angering, or shaming those who are targeted. India happens to be one of the rapidly improving countries in the cyber world and thus faces a lot of problems regarding cyber crimes, especially cyberbullying.

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Introduction: Alcohol and tobacco use has been proposed to significantly affect COVID-19 outcomes. The study aimed to estimate the prevalence of alcohol and tobacco use among COVID-19-positive patients and compare it with the general population prevalence rates. It also aimed to assess and determine the association between the severity of COVID-19 illness and the complications with alcohol and tobacco use.

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Enlightening a 'Dark Brain': Essential Insights for Every Stroke Specialist.

Neurol India

July 2024

Department of Clinical Neurosciences (Virtual), Incharge Stroke and Headache Services, National Institute of Mental Health and Neurosciences (NIMHANS), Institute of National Importance (INI), Bengaluru, Karnataka, India.

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Super refractory status epilepticus (SRSE) is a condition associated with high rates of mortality and morbidity. We report the treatment protocol of magnesium sulphate infusion adapted for the management of a case of super refractory status epilepticus that lasted for 4 weeks. A young lady presented in altered sensorium with a history of fever followed by uncontrolled seizures of 2 weeks duration.

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Background: The ideal goal of treatment for medium to large vestibular schwannoma is complete tumor removal with preservation of all cranial nerves. However, despite the advancements in microsurgery and intraoperative monitoring, the risk of facial nerve dysfunction following total resection varies between 31% and 57%. Currently, the goal of treatment for large tumors is shifting from total excision to facial nerve preservation.

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Background: Disturbed sleep and its impact on quality of life (QoL) are underrecognized in myasthenia gravis (MG).

Aims: To evaluate the quality of sleep in MG using standard sleep questionnaires and assess factors that determine sleep.

Settings And Design: Prospective, cross-sectional, hospital-based study.

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 Knowledge of preoperative and intraoperative intracranial pressure (ICP) enables the neuroanesthesiologist to optimize cerebral perfusion pressure. However, ICP is rarely monitored during the intraoperative period. In this report, subdural site ICP measurement is validated with intraventricular ICP measurement, and the feasibility of subdural ICP monitoring during the intraoperative period is discussed.

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