12 results match your criteria: "National Institute of Medicinal Materials (NIMM)[Affiliation]"

In this work, the volatile components of Erigeron sublyratus essential oils and their anti-inflammatory and cytotoxic activities were investigated for the first time. Gas chromatography-mass spectrometry (GC-MS) analysis identified 28 components in the root and aerial part essential oils. The main components included cis-lachnophyllum ester (53.

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Astraoleanosides E-P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity.

Bioorg Chem

April 2024

Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:

Historically, Astragalus membranaceus Bunge has been used as a beneficial medicinal plant, particularly in the Asian traditional medical systems, for the treatment of various human diseases such as stomach ulcers, diarrhea, and respiratory issues associated with phlegm. In this study, a phytochemical characterization of the aerial parts of A. membranaceusled to the isolation of 29 oleanane-type triterpenoid saponins, including 11 new compounds named astraoleanosides E-P (6-9, 13, 14, 18-22), as well as 18 known ones.

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Four new polyhydroxy pregnane glycosides, named volubilosides G-K (3, 5-7), along with three known secondary metabolites, dregeoside D (1), dregeoside K (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1-7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR-ESI-MS analyses) and compared with those in the published literature. Compounds (1-7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN-7, HT29, A549, MCF-7, MDA-MB-231, and HepG2), revealing varying levels of cytotoxic effects with IC values ranging from 4.

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Pharmacological properties of Ensete glaucum seed extract: Novel insights for antidiabetic effects via modulation of oxidative stress, inflammation, apoptosis and MAPK signaling pathways.

J Ethnopharmacol

February 2024

National Institute of Medicinal Materials (NIMM), Hanoi, 100000, Viet Nam; Research Center of Ginseng and Medicinal Materials (CGMM), National Institute of Medicinal Materials, Ho Chi Minh City, 700000, Viet Nam. Electronic address:

Ethnophamacological Relevance: Medicinal plants are increasingly making important contributions to diabetic treatment. Ensete glaucum seeds have been widely used in folk medicine to treat diabetes.

Aim Of The Study: The study was aimed to investigate the protective effect and active mechanisms of E.

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Species belonging to the (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 - 3), designated as vernogratiosides A-C, from whole plants of .

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Bio-guided fractionation of the 80% ethanol extract of the aerial parts of Elsholtzia penduliflora W. W. Smith (Lamiaceae) led to the isolation of seven new triterpene glycosides, i.

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Article Synopsis
  • * These compounds were identified using advanced techniques like NMR spectroscopy and mass spectrometry, ensuring their structures were clearly defined.
  • * Tested on 3T3-L1 cells, compounds gycomol VN2 and various gycomosides were found to activate AMPK and ACC, suggesting their potential role in preventing obesity by influencing important metabolic pathways.
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Four new triterpenoid saponins (gouaniasides VII-IX [] and joazeiroside C []) and one known triterpenoid () were isolated from the aerial parts of DC. (Rhamnaceae). Their structures were elucidated via one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, high-resolution electrospray ionisation-mass spectrometry, and analyses of hydrolytic cleavage results.

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Article Synopsis
  • The agro-climatic conditions in North-East India pose challenges for rice cultivation, but local rice cultivars have adapted to these harsh environments.
  • Genetic engineering offers a way to introduce desirable traits into these cultivars, although there is limited information on how to do this effectively.
  • This study developed efficient procedures for transforming North-East rice cultivars to create transgenic plants, achieving successful plant regeneration in just 35-45 days, which can aid in introducing new traits and studying gene functions.
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An HPLC-DAD method for the quality control of wild and cultivated Ganoderma lucidum (Linhzhi) and related species samples was developed and validated. The quantitative determination of G. lucidum and its related species using 14 triterpene constituents, including nine ganoderma acids (compounds 4-12), four alcohols (compounds 13-16), and one sterol (ergosterol, 17) were reported.

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In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress.

J Ethnopharmacol

December 2013

National Institute of Medicinal Materials (NIMM), 3B Quangtrung, Hoankiem, Hanoi, Vietnam; College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.

Ethnopharmacological Relevance: Ganoderma lucidum (Fr.) Karst. (Ganodermataceae) is a mushroom which is used as a traditional remedy in the treatment of human diseases such as hepatitis, liver disorders, hypercholesterolemia, arthritis, bronchitis and tumorigenic diseases.

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