6 results match your criteria: "National Institute of Medical Sciences University[Affiliation]"
Dental practice closure during the first wave of COVID-19 and associated professional, practice and structural determinants: a multi-country survey.
BMC Oral Health
May 2021
Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Champlion St., Azarita, Alexandria, 21527, Egypt.
Article Synopsis
- The COVID-19 pandemic significantly impacted dental practices globally, with a high risk of cross-infection for both dentists and patients due to the nature of dental settings.
- Most participating dentists (75.9%) reported that their practices were closed during the first wave of the pandemic, with private sector closures more common than those in the non-private sector.
- Factors influencing closures included heightened pandemic fears and sector type, with rural non-private dentists and those in hospitals reporting lower closure likelihood, while academic dentists had a higher likelihood of closing their practices.
Eventration of the right hemidiaphragm with multiple associations: A rare presentation.
Lung India
October 2014
Department of Respiratory Medicine, National Institute of Medical Sciences University, Jaipur, Rajasthan, India E-mail:
Effectiveness of spray congealing to obtain physically stabilized amorphous dispersions of a poorly soluble thermosensitive API.
AAPS PharmSciTech
December 2014
Department of Pharmaceutics, Institute of Pharmacy, National Institute of Medical Sciences University, Jaipur, 303121, Rajasthan, India,
An amorphous phase produced by micronization up to the molecular or colloidal level of a poorly soluble drug having low lipophilicity can distinctly enhance its solubility characteristics. However, though dispersing the molten mass of a poorly water-soluble drug within polymeric matrix has been found to be most effective in formation of molecular dispersions, the drug molecules which melt at high temperature also accompanied by decomposition, such as acetazolamide, are difficult to formulate as molecular dispersions. Hence, a method is proposed to obtain molecular dispersions of acetazolamide with poloxamer-237 by spray congealing under optimal heat treatment.
View Article and Find Full Text PDFFreeze-dried amorphous dispersions for solubility enhancement of thermosensitive API having low molecular lipophilicity.
Drug Res (Stuttg)
September 2014
Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, Egypt.
The present study focuses on the development of an alternative 'thermally gentle' strategy such as freeze-drying to obtain not only solubility enhanced but also physically stabilised amorphous solid dispersions of acetazolamide, which melt with decomposition (M.P.~260°C).
View Article and Find Full Text PDFDrug resinates an attractive approach of solubility enhancement of atorvastatin calcium.
Indian J Pharm Sci
September 2013
Department of Pharmaceutics, Modern College of Pharmacy, Nigdi, Pune-411 044, India.
A substantial number of new chemical entities and marketed drugs show poor solubility characteristics and amorphisation is one of the favorable approaches to enhance solubility characteristics of such poorly soluble drugs. Formulation efforts in the present study were devoted to investigate amorphisation of a model poorly soluble drug, atorvastatin calcium by molecular complexation with anion exchange resin, Duolite(®)AP 143/1093 and hence enhancement in its solubility characteristics. Drug resinates in 1:1, 1:2, and 1:4 weight ratios were prepared by simple batch operation and subsequently studied for drug content, residual solvent content, molecular interactions, solid state characterisation and solubility characteristics.
View Article and Find Full Text PDFDiscovery of novel antitubercular 1,5-dimethyl-2-phenyl-4-([5-(arylamino)-1,3,4-oxadiazol-2-yl]methylamino)-1,2-dihydro-3H-pyrazol-3-one analogues.
Bioorg Med Chem Lett
January 2012
New Drug Discovery Research, Department of Pharmaceutical Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301 030, India; Department of Pharmaceutical Sciences, National Institute of Medical Sciences University, Jaipur, Rajasthan 303 121, India.
In search of potential therapeutics for tuberculosis, we describe herewith the synthesis, characterization and antimycobacterial activity of 1,5-dimethyl-2-phenyl-4-([5-(arylamino)-1,3,4-oxadiazol-2-yl]methylamino)-1,2-dihydro-3H-pyrazol-3-one analogues. Among the synthesized compounds, 4-[(5-[(4-fluorophenylamino]-1,3,4-oxadiazol-2-yl)methylamino]-1,2-dihydro-1,5-dimethyl-2-phenylpyrazol-3-one (4a) was found to be the most promising compound active against Mycobacterium tuberculosis H(37)Rv and isoniazid resistant M. tuberculosis with minimum inhibitory concentrations, 0.
View Article and Find Full Text PDF