521 results match your criteria: "National Institute of Laser[Affiliation]"

Purpose: Anterior segment optical coherence tomography (AS-OCT) is increasingly being used to complement slit-lamp biomicroscopy in the evaluation of corneal infections. Our purpose was to analyze, compare, and correlate the clinical signs elicited by these 2 methods in patients with infectious keratitis (IK).

Methods: Slit-lamp photomicrographs (diffuse and slit beam) and AS-OCT scans were obtained from 20 consecutive patients (21 eyes) with IK.

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Objective: We sought to compare the safety and efficacy of combining fractional 2940-nm Erbium:YAG (Er:YAG) laser with autologous platelet-rich plasma (PRP) versus its combination with low-level laser therapy (LLLT) for enhancing the outcome of postsurgical and post-traumatic scars.

Methods: Fourty-five individuals with post-surgical or post-traumatic scars were randomly divided into three groups: Group A received four fractional Er:YAG laser sessions spaced four weeks apart along with eight sessions of intradermal PRP injections spaced two weeks apart; Group B received four fractional Er:YAG laser sessions spaced four weeks apart along with two sessions of light emitting diode (LED) weekly; and Group C received four fractional Er:YAG laser sessions spaced four weeks apart. Treatment efficacy was evaluated using clinical photographs, Vancouver Scar Scale (VSS), patient satisfaction and histopathology.

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Exploring the role of exosomal lncRNA in cancer immunopathogenesis: Unraveling the immune response and EMT pathways.

Exp Cell Res

December 2024

Medical Laboratory Technique College, The Islamic University, Najaf, Iraq; Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq. Electronic address:

Exosomes are membrane-bound vesicles secreted by diverse cell types, serving as crucial mediators in intercellular communication and significantly influencing cancer development. Exosomes facilitate complex signaling processes in the tumor microenvironment for immunomodulation, metastasis, angiogenesis, and treatment resistance. Notably, long non-coding RNAs (lncRNAs), a class of non-coding RNAs, engage with mRNA, DNA, proteins, and miRNAs to modulate gene expression through multiple mechanisms, including transcriptional, post-transcriptional, translational, and epigenetic pathways.

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Corneal alkali burns persist as a significant challenge in our field, often leading to a prolonged treatment course with various sight-threatening problems. This work, of utmost importance, aimed to apply the photo-tissue bonding technique (PTB) to weld the amniotic membrane (AM) to the corneal surface versus an amniotic membrane graft (AMG) and explore its safety in saving corneal protein against alkali burn.Methods Twenty-seven rabbits with an induced corneal ulcer using 1 mol/L NaOH solution.

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Targeting breast tumor extracellular matrix and stroma utilizing nanoparticles.

Clin Transl Oncol

December 2024

Department of Refrigeration and air Conditioning Techniques, College of Technical Engineering, The Islamic University, Najaf, Iraq.

Breast cancer is a complicated malignancy and is known as the most common cancer in women. Considerable experiments have been devoted to explore the basic impacts of the tumor stroma, particularly the extracellular matrix (ECM) and stromal components, on tumor growth and resistance to treatment. ECM is made up of an intricate system of proteins, glycosaminoglycans, and proteoglycans, and maintains structural support and controls key signaling pathways involved in breast tumors.

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Melatonin enhances metal oxide nanoparticles tolerance in rice seedlings through dual regulation of antioxidant defense and photosynthetic efficiency.

Physiol Plant

December 2024

Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education, Agriculture College of Yangzhou University, Yangzhou, China.

The growing utilization of metal oxide nanoparticles (MONPs) presents novel and potential hazards to plants. However, the impacts of MONPs on plants and the mechanisms underlying their tolerance to MONPs remain unclear. In this study, we demonstrated that both CuO and ZnO nanoparticles hindered plant growth and triggered oxidative damage in rice seedlings.

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Background: Psoriasis is a common chronic systemic disease affecting the skin, nails, and joints. Nails are commonly associated with a greater severity of the disease. Radiofrequency (RF) is a nonionizing radiation that provides energy originating from electric current to generate heat inside the dermis with anti-inflammatory effects.

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Photobiomodulation (PBM) is beneficial to biological tissues; depending on the optical dose that is absorbed by tissues, it can function as a biostimulative, analgesic, and anti-inflammatory mediator. Thus, the current research aimed to assess the impacts of PBM and Calcium aluminosilicate-based material on direct pulp capping (DPC) of dogs' permanent teeth through histological analysis. To study DPC of dogs' teeth, we separated 24 canines and premolars obtained from mature, healthy mongrel dogs into four equal groups: group 1, which served as the control (exposed pulp was covered with a sterile polytetrafluoroethylene, Teflon tape); group 2, which received PBM treatment using a 980 nm diode laser with a 100 mw output power for one minute; group 3: Calcium aluminosilicate-based material; group 4: Calcium aluminosilicate+PBM.

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The present study involved the preparation of a nano-polymer based on shrimp wastes as a biodegradable chitosan nanoparticle (Cs) incorporated into titanium oxide nanoparticles (TiO) in an aqueous medium and carried on the specific polymer to form thin films. The spectroscopic properties of chitosan/TiO/Polymer thin films were estimated by transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. The fabricated films were then examined for their potential to eliminate iron (Fe) and chromium (Cr) from solutions.

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Reducing the effective dose of doxycycline using chitosan silver nanocomposite as a carriers on gram positive and gram-negative bacteria.

Sci Rep

November 2024

Department of Laser Sciences and Interactions, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza, Egypt.

Doxycycline (Doxy) is a tetracycline antibiotic with a potent antibacterial activity against a broad range of bacteria. Using nanotechnology is one feasible way to increase the antibiotics' ability to penetrate the body and increase their antibacterial effectiveness. In this work, we report the formation of a stable green synthesized silver nanoparticles (AgNPs) by chitosan with Doxy nanocomposite for the first time.

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Article Synopsis
  • The study explores how infrared diode laser treatment affects the growth and development of periodontal ligament stem cells (hPDLSCs), which are crucial for dental tissue repair.
  • Infrared laser application at a specific power and duration significantly improved the viability and differentiation of hPDLSCs, showcasing increased expression of important stem cell and osteogenic markers.
  • These results highlight potential clinical uses of infrared lasers combined with stem cells to enhance periodontal tissue regeneration and improve dental healing processes.
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Effects of Photobiomodulation Using Low-Power Diode Laser Therapy and Nano-bone on Mandibular Bone Regeneration in Rats.

J Lasers Med Sci

October 2024

Medical Applications of Lasers Department, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza, Egypt.

Article Synopsis
  • Recent research explored the effects of photobiomodulation (PBM) and nano-bone on mandibular bone repair in mice with created bone defects.
  • The study involved four groups: a control group, a group receiving PBM treatment, a group using nano-bone, and a group combining both PBM and nano-bone, with evaluations at one, two, and four weeks.
  • Results showed that the combination of PBM and nano-bone led to less inflammation and significantly greater new bone formation compared to other groups, suggesting their potential for enhancing bone regeneration.
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The telecommunication wavelengths are crucial for developing a photonic integrated circuit (PIC). The absorption fingerprints of many gases lie within these spectral ranges, offering the potential to create a miniaturized gas sensor for PIC. This work presents novel double Fano resonances within the telecommunication band, based on silicon metasurfaces for selective gas sensing applications.

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Chemotherapy is the most common cancer treatment, and metallic anticancer compounds have generated increasing amounts of interest since the discovery of cisplatin. More recently, scientists have focused on ruthenium-based compounds as alternatives for platinum compounds, which seem like ideal therapeutic anticancer alternatives to platinum derivatives. The present study aims to assess whether one or more of three Ruthenium-based nanocomposites, namely Ru+Lysine+CTAB (RCTL), Ru+CTAB (RCT), and Ru+Lysine (RL) exhibit pronounced anti-proliferative properties against different cancer cells.

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Article Synopsis
  • Cellulite (CLT) is a common cosmetic issue for women, characterized by dimpled skin, and is usually treated with invasive methods like liposuction, but safer topical treatments are preferred.
  • This study developed a solid lipid nanoparticle formulation containing caffeine (CA) to enhance its absorption and effectiveness against cellulite, achieving high entrapment efficiency and optimal particle characteristics.
  • The final product, CA-SLN-Ngel, demonstrated significant reductions in subcutaneous fat tissue thickness in histological studies, suggesting it could be an effective non-invasive treatment for cellulite.
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Aluminum phthalocyanine tetrasulfonate conjugated to surface-modified Iron oxide nanoparticles as a magnetic targeting platform for photodynamic therapy of Ehrlich tumor-bearing mice.

Photodiagnosis Photodyn Ther

December 2024

Pharmaceutical Nanotechnology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences, Cairo University, Egypt. Electronic address:

Background: Photodynamic therapy (PDT) is a targeted treatment option for cancers that are non-responding to ordinary anticancer therapies. It involves activating a photosensitizer with a light source of a specific wavelength to destroy targeted cells and their surrounding vasculature. Aluminum phthalocyanine tetra sulfonate (AlPcS) has gained attention as a second-generation photosensitizer for its strong absorption in the red-light region.

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Heterostructures of magnetite (FeO) nanoparticles and reduced graphene oxide (RGO) sheets are very common composite materials for different applications such as catalysis, energy storage, and biomedicine. Developing methods for the facile control of the size and shape of both freestanding FeO nanoparticles and those anchored onto RGO sheets is in demand. Herein, we report on the rapid and facile microwave synthesis (MWS) of FeO nanoparticles and FeO/RGO with various sizes and shapes using the oleylamine (OAm)/oleic acid (OAc) ligand pair.

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Atrazine is a widely used toxic herbicide that poses a threat to both the environment and human health. This study investigates the removal of Atrazine from water through armchair-hexagonal hexagonal graphene quantum dots (AHEX) simulations. The investigations are performed using density functional theory at the exchange-correlation hybrid functional B3LYP/3-21G level of theory.

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Asthma is a severe respiratory disease marked by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG), a polysaccharide constituent of fungal cellular structures, exhibits potent immunomodulatory activities. The investigational focus was on the anti-asthmatic and anti-ferroptotic properties of beta-glucan nanoparticles (BG-NPs) in a murine model of allergic asthma induced by ovalbumin (OVA).

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Smart photochromic and fluorescent textile refers to garments that alter their colorimetric properties in response to external light stimulus. Cotton fibers have been reported as a main resource for many textile and non-textile industries, such as automobiles, medical devices, and furniture applications. Cotton is a natural fiber that is distinguished with breathability, softness, cheapness, and highly absorbent.

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Purpose: The antibacterial properties of silver nanoparticles (AgNPs) are extensively identified. In large quantities, they might be harmful. So many fields of nanotechnology have shown a great deal of interest in the development of an environmentally friendly, efficient method for synthesizing metal nanoparticles.

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In recent research, there has been a significant focus on establishing robust quantum cryptography using the continuous-variable quantum key distribution (CV-QKD) protocol based on Gaussian modulation of coherent states (GMCS). Unlike more stable fiber channels, one challenge faced in free-space quantum channels is the complex transmittance characterized by varying atmospheric turbulence. This complexity poses difficulties in achieving high transmission rates and long-distance communication.

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Using plant extracts as photosensitizers in photodynamic therapy (PDT) represents a significant green approach toward sustainability. This study investigates beetroot juice (BRJ), betanin, and their liposomal formulations (Lip-BRJ, Lip-Bet) as photosensitizers in cancer PDT. BRJ was prepared, and its betanin content was quantified via HPLC.

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Bioactive glass is currently considered a material with a high biocompatibility and has been used both in the field of bone regeneration and in the preparation of cosmetic products with the controlled release of active compounds. The present work involved a study on the synthesis of bioglass using the sol-gel process. The study aims to evaluate the influence of the treatment of bioglass with Polyethylene glycol 4000 (PEG 4000) on its main characteristics.

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Impact of Photobiomodulation and Melatonin on Periodontal Healing of Periodontitis in Immunosuppressed Rats.

J Lasers Med Sci

August 2024

Medical applications of lasers Department, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza, Egypt.

Periodontitis is an inflammatory disease due to bacterial origin; it has a chronic course and progresses by immunosuppressive therapy. However, adjuvant therapies such as photobiomodulation (PBM) and melatonin can reduce the severity of the inflammation and inhibit the progression of periodontitis. Therefore, the present study evaluated the effects of PBM (PBM) and melatonin, as adjuvant therapies, on periodontal healing in immunosuppressed rats with periodontitis.

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